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The map label for this gene is serA [H]

Identifier: 59712713

GI number: 59712713

Start: 2340856

End: 2342085

Strand: Direct

Name: serA [H]

Synonym: VF_2106

Alternate gene names: 59712713

Gene position: 2340856-2342085 (Clockwise)

Preceding gene: 59712712

Following gene: 59712718

Centisome position: 80.79

GC content: 38.86

Gene sequence:

>1230_bases
ATGGCAAAAGTATCTCTGGAAAAAGAAAAAATCAAAATTCTTCTTTTAGAAGGATTGCATCCATCTTGTGTTGAAGTTTT
CCAAGCAGATGGTTACACCAATATTGAATACCACAAAGGTTCACTCTCTGAAGAAGAACTCTTAGAAGCAGTAAAAGACG
TTCATTTTATTGGTCTTCGCTCCCGCACTCAATTAACACAAGAAGTATTTGAGGCTGCAAACAAATTGGTTGCTGTTGGT
TGTTTCTGTATCGGTACAAACCAAGTTGATTTAAAAGCAGCCGCAAAGCGTGGTATTCCAGTATTCAATGCTCCTTTCTC
TAATACTCGAAGCGTTGCTGAATTAGTTTTAGGTCAAATTCTACTATTACTTCGTGGTATCCCAGAAAAGAATGCATTAG
CACACCGTGGTATTTGGAAAAAAAGTGCTGACGCTTCTTTTGAAGCTCGAGGCAAACGTTTGGGTATCATAGGTTATGGA
CATATCGGTACACAATTAGGCATTTTAGCTGAAAACCTAGGTATGCGAGTTTATTACTACGATATCGAAAATAAACTTTC
TCTAGGTAACGCAACTCAAATCCCAACCATGAGTGAATTATTAAATAAGTGTGATGTGATCTCTCTACATGTTCCTGAAA
CAGCTGGAACAAAAGACATGATGGGTGCAGAAGAATTTGCTCGTATGAAACCAGGGGCTATCTTTATTAACGCTGCACGT
GGAACTGTTGTAAAAATTCAAGATCTATGTGACGCATTAGAGTCTGGGCATTTAGGTGGCGCAGCGGTTGATGTGTTCCC
TGTAGAACCAAAAACAAACGCTGACCCATTTGAGTCACCATTACAAAAGTTTGATAATGTAATCTTAACGCCGCATGTTG
GGGGGTCTACTCAAGAAGCTCAAGAAAACATTGGGGTTGAAGTTGCGGGTAAACTAACAAAATACTCAGATAATGGTTCA
ACATTATCATCAGTTAACTTCCCTGAAGTGTCACTTCCTGAACATACTGATACATCACGTTTATTGCATATCCATGAAAA
CCGTCCAGGTATTCTAACTCAAATAAACAGTATTTTTGCTAATGAAGGCATTAACATTGCAGCTCAATACTTACAAACAT
CAGCAGATATGGGCTATGTTGTTATTGATGTTGAAACCGCACGAGCTGAAGAAGCTCTGGTTCAACTAAAAGCAATTGAA
GGCACTATCCGCGCTCGAATTCTTCATTAA

Upstream 100 bases:

>100_bases
ATTCCGTAATTTTCTTACCCAAACTGATTATTTTTTGATACTTTATAATCAGCAAGCAATAAATCACATCATAATTTTGT
TTTTAAGGATAAGAACGACC

Downstream 100 bases:

>100_bases
GATAAATAAAAAATGGGCAGCTTAATTAGCTGCCCATTTTATTCATATTAAATAATGTAATCAGTTAAGTCGATATACAA
CAGATACAGAGTCAGAAATC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFEAANKLVAVG
CFCIGTNQVDLKAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADASFEARGKRLGIIGYG
HIGTQLGILAENLGMRVYYYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
GTVVKIQDLCDALESGHLGGAAVDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGS
TLSSVNFPEVSLPEHTDTSRLLHIHENRPGILTQINSIFANEGINIAAQYLQTSADMGYVVIDVETARAEEALVQLKAIE
GTIRARILH

Sequences:

>Translated_409_residues
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFEAANKLVAVG
CFCIGTNQVDLKAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADASFEARGKRLGIIGYG
HIGTQLGILAENLGMRVYYYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
GTVVKIQDLCDALESGHLGGAAVDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGS
TLSSVNFPEVSLPEHTDTSRLLHIHENRPGILTQINSIFANEGINIAAQYLQTSADMGYVVIDVETARAEEALVQLKAIE
GTIRARILH
>Mature_408_residues
AKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLRSRTQLTQEVFEAANKLVAVGC
FCIGTNQVDLKAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADASFEARGKRLGIIGYGH
IGTQLGILAENLGMRVYYYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETAGTKDMMGAEEFARMKPGAIFINAARG
TVVKIQDLCDALESGHLGGAAVDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLTKYSDNGST
LSSVNFPEVSLPEHTDTSRLLHIHENRPGILTQINSIFANEGINIAAQYLQTSADMGYVVIDVETARAEEALVQLKAIEG
TIRARILH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=36.5930599369085, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=30, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=28.8461538461538, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=30, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=26.9090909090909, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=72.992700729927, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=30.8300395256917, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1787645, Length=243, Percent_Identity=30.8641975308642, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87081824, Length=150, Percent_Identity=30, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=25.4681647940075, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=32.5077399380805, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=294, Percent_Identity=27.891156462585, Blast_Score=98, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=393, Percent_Identity=48.6005089058524, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=47.3429951690821, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324055, Length=284, Percent_Identity=27.112676056338, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=257, Percent_Identity=27.2373540856031, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=34.5514950166113, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=29.4339622641509, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646446, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646448, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646452, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24646450, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=28.6689419795222, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=26.0726072607261, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=25.089605734767, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45551003, Length=286, Percent_Identity=24.4755244755245, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=25.089605734767, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=25.089605734767, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44439; Mature: 44308

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLR
CCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHEECCC
SRTQLTQEVFEAANKLVAVGCFCIGTNQVDLKAAAKRGIPVFNAPFSNTRSVAELVLGQI
HHHHHHHHHHHHHHHEEEEEEEEECCCCEEHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADASFEARGKRLGIIGYGHIGTQLGILAENLGMRVYYY
HHHHCCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIPTMSELLNKCDVISLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCHHHCCHHHHHHCCCCEEEEECCC
GTVVKIQDLCDALESGHLGGAAVDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLTKYSDNGSTLSSVNFPEVSLPEHTDTSRLLHIHENRPGILTQINSIFA
HHHCCEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
NEGINIAAQYLQTSADMGYVVIDVETARAEEALVQLKAIEGTIRARILH
CCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCEEEEEECC
>Mature Secondary Structure 
AKVSLEKEKIKILLLEGLHPSCVEVFQADGYTNIEYHKGSLSEEELLEAVKDVHFIGLR
CCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHEECCC
SRTQLTQEVFEAANKLVAVGCFCIGTNQVDLKAAAKRGIPVFNAPFSNTRSVAELVLGQI
HHHHHHHHHHHHHHHEEEEEEEEECCCCEEHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADASFEARGKRLGIIGYGHIGTQLGILAENLGMRVYYY
HHHHCCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIPTMSELLNKCDVISLHVPETAGTKDMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCHHHCCHHHHHHCCCCEEEEECCC
GTVVKIQDLCDALESGHLGGAAVDVFPVEPKTNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLTKYSDNGSTLSSVNFPEVSLPEHTDTSRLLHIHENRPGILTQINSIFA
HHHCCEEEEEEEEEECCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHH
NEGINIAAQYLQTSADMGYVVIDVETARAEEALVQLKAIEGTIRARILH
CCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]