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The map label for this gene is cheA [H]

Identifier: 59712438

GI number: 59712438

Start: 2063122

End: 2065329

Strand: Reverse

Name: cheA [H]

Synonym: VF_1831

Alternate gene names: 59712438

Gene position: 2065329-2063122 (Counterclockwise)

Preceding gene: 59712439

Following gene: 59712437

Centisome position: 71.28

GC content: 41.03

Gene sequence:

>2208_bases
ATGAGCTTTGAAATGGATGAAGACATCCTGCAAGATTTCTTAATTGAAGCAGGAGAAATTCTCGAGCTACTTTCTGAACA
ATTAGTTGAATTAGAGCAACGCCCTGATGATGCTGATTTATTAAATGCTATTTTCCGTGGTTTTCATACCGTTAAAGGCG
GTGCAGGCTTTTTGTCATTAACTGAATTAGTTGATGCTTGTCATGGTGCGGAAAACGTATTTGATATTCTTAGAACAGGT
AAACGTAAAGTTACTTCTGAGCTAATGGATACCATCTTACAAGCACTTGATACCGTGAATGTTATGTTCAGTTCAGTGCA
AAATGGTGAAGCTTTAGAGCCGGCAGAACAAAGCTTGCTTGATGAACTGCATCGTTTAAGCAAACCTGCATCAGAAGATG
AAATTGCATCAGCAGCAAATGAAGCTGTTGTTGAAGATATCGTTATTGAAGAGTCAGTAATTGAAGTAACTCCTTCTGTA
GAAGAGGTTTCTGTTTCGGCTAATAATCATGATTCTGTTGATGATATTACAGAAGATGAATTTGAACGATTATTAGATGA
ATTACACGGTAAAGGCGCATCTCCAAGTAGTGCCGCTTCAGTAACACCAGCTCCTGCTGCGCCTATTGCATCGTCAACAA
GTGCTGATGATGGCGATATTACTGATGATGAGTTTGAGCGTCTGCTTGATGAACTTCATGGTTCAGGTAAAAGCCCAAGT
AATGCAACGACAACTCCTGCTGCTAAACCGGTAGAAGACATACTGTCAAATTCTGGTGATTCAGATTTAATGACAGATGA
TGAGTTTGAGAAATTACTTGATCAACTGCACGGTTCAGGCAAAGGTCCAACGGAAGAAGAGCTTGATCAAGCTGTTCAAC
CTGTTGCTGCGATGAATCAGACAACAAGTGCACCAGCACCTGTAGTTGAAGCACCAACAAGAACAACGGCACCTGCGCCG
ACAAGAACACAAGCACCGAAAGAAGATGTGAAAGCGGTTGCAAAGGCACCAGCAAAAGCGCCAGCAAAATCACAATCAGA
AAGTACGGTACGTGTTGATACATCAACGCTAGATAACATCATGAATATGGTGGGAGAGCTTGTACTTGTTCGAAACCGTT
TGGTGAGTTTAGGTTTGAATAGCAATGACGAAGAAATGTCAAAAGCGGTATCAAACCTAGATGTGGTTACTGCAGACCTT
CAAGGTGCAGTAATGAAAACTCGTATGCAACCAATTAAGAAAGTATTTGGTCGTTTCCCACGAGTTGTACGTGACTTGGC
TCGTACACTGAAGAAAGACATCGTGCTAGAAATGCGCGGTGAAGAAACTGATTTAGATAAAAACTTGGTTGAAGCGCTTG
CCGATCCATTGATTCACTTAGTTCGTAACTCTGTAGATCATGGTATTGAAATGCCTGATGACCGTTTAAAAGCGGGTAAA
GATCGCACAGGTAAAGTGATTTTATCAGCATCTCAAGAAGGGGATCACATCTTACTGAGCATCATTGATGATGGCGGCGG
TATGGATGCAGATAAACTTCGTGGTATTGCGGTAAACCGAGGTTTGATGGACAGCGATGCTGCATCACGCTTAACAAATA
AAGAATGTTATAACCTTATTTTTGCACCAGGTTTCTCAACTAAGACTGAAATTTCAGATATTTCAGGTCGTGGTGTAGGT
ATGGACGTGGTTAAAACAGCGATCAACCAACTAAATGGTTCAATTGATATTGATTCAAACATGGGTGAAGGTACTAAGAT
CGTAATCAAAGTGCCACTGACTCTTGCAATCTTACCAACGTTAATGGTTGGTGTTGCGAATCAACCATTTGCACTTCCAT
TAGCAAGTGTAAATGAGATTTTCCATCTTGATCTGTCTAAGACAAACATCGTTGATGGTCAATTAACAACAATTGTTCGT
GAAAAGTCGATCCCACTGTTCTTCTTACAAGATTGGTTGGTTCCTGGTAGTCGTCAAACAGAACGTACAGGGTTAGGTCA
TGTTGTAATTATTCAACTTGGCGCTCAACGTGTTGGTTTTGTTGTTGATACCTTAATAGGTCAAGAAGAAGTGGTTATTA
AACCGCTAGATGAACTATTGCAAGGTACTCCAGGTATGGCAGGTGCAACGATTACTTCTGATGGTCATATTGCATTGATC
CTTGACGTTCCTAACTTGTTAAAGCGTTACGCCGTTCGCATGCGTTAA

Upstream 100 bases:

>100_bases
TGAAGGACCAATTATCAACCCGCATGAACGCGAAGACGCTGTAGCATCTCAAGATGATGTTGATGACCTATTAGCCAGTC
TAGGATTTTAGAGGAATACT

Downstream 100 bases:

>100_bases
TGCACAAGGATTGACATGGCTATAAAAGTATTAGTGGTAGATGATTCTAGTTTTTTCCGCCGCCGAGTAAGTGAAATTAT
CAATTCAGATCCACGTCTTG

Product: chemotactic sensory histidine kinase CheA, in two-component regulatory system with CheB and CheY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MSFEMDEDILQDFLIEAGEILELLSEQLVELEQRPDDADLLNAIFRGFHTVKGGAGFLSLTELVDACHGAENVFDILRTG
KRKVTSELMDTILQALDTVNVMFSSVQNGEALEPAEQSLLDELHRLSKPASEDEIASAANEAVVEDIVIEESVIEVTPSV
EEVSVSANNHDSVDDITEDEFERLLDELHGKGASPSSAASVTPAPAAPIASSTSADDGDITDDEFERLLDELHGSGKSPS
NATTTPAAKPVEDILSNSGDSDLMTDDEFEKLLDQLHGSGKGPTEEELDQAVQPVAAMNQTTSAPAPVVEAPTRTTAPAP
TRTQAPKEDVKAVAKAPAKAPAKSQSESTVRVDTSTLDNIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADL
QGAVMKTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRLKAGK
DRTGKVILSASQEGDHILLSIIDDGGGMDADKLRGIAVNRGLMDSDAASRLTNKECYNLIFAPGFSTKTEISDISGRGVG
MDVVKTAINQLNGSIDIDSNMGEGTKIVIKVPLTLAILPTLMVGVANQPFALPLASVNEIFHLDLSKTNIVDGQLTTIVR
EKSIPLFFLQDWLVPGSRQTERTGLGHVVIIQLGAQRVGFVVDTLIGQEEVVIKPLDELLQGTPGMAGATITSDGHIALI
LDVPNLLKRYAVRMR

Sequences:

>Translated_735_residues
MSFEMDEDILQDFLIEAGEILELLSEQLVELEQRPDDADLLNAIFRGFHTVKGGAGFLSLTELVDACHGAENVFDILRTG
KRKVTSELMDTILQALDTVNVMFSSVQNGEALEPAEQSLLDELHRLSKPASEDEIASAANEAVVEDIVIEESVIEVTPSV
EEVSVSANNHDSVDDITEDEFERLLDELHGKGASPSSAASVTPAPAAPIASSTSADDGDITDDEFERLLDELHGSGKSPS
NATTTPAAKPVEDILSNSGDSDLMTDDEFEKLLDQLHGSGKGPTEEELDQAVQPVAAMNQTTSAPAPVVEAPTRTTAPAP
TRTQAPKEDVKAVAKAPAKAPAKSQSESTVRVDTSTLDNIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADL
QGAVMKTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRLKAGK
DRTGKVILSASQEGDHILLSIIDDGGGMDADKLRGIAVNRGLMDSDAASRLTNKECYNLIFAPGFSTKTEISDISGRGVG
MDVVKTAINQLNGSIDIDSNMGEGTKIVIKVPLTLAILPTLMVGVANQPFALPLASVNEIFHLDLSKTNIVDGQLTTIVR
EKSIPLFFLQDWLVPGSRQTERTGLGHVVIIQLGAQRVGFVVDTLIGQEEVVIKPLDELLQGTPGMAGATITSDGHIALI
LDVPNLLKRYAVRMR
>Mature_734_residues
SFEMDEDILQDFLIEAGEILELLSEQLVELEQRPDDADLLNAIFRGFHTVKGGAGFLSLTELVDACHGAENVFDILRTGK
RKVTSELMDTILQALDTVNVMFSSVQNGEALEPAEQSLLDELHRLSKPASEDEIASAANEAVVEDIVIEESVIEVTPSVE
EVSVSANNHDSVDDITEDEFERLLDELHGKGASPSSAASVTPAPAAPIASSTSADDGDITDDEFERLLDELHGSGKSPSN
ATTTPAAKPVEDILSNSGDSDLMTDDEFEKLLDQLHGSGKGPTEEELDQAVQPVAAMNQTTSAPAPVVEAPTRTTAPAPT
RTQAPKEDVKAVAKAPAKAPAKSQSESTVRVDTSTLDNIMNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQ
GAVMKTRMQPIKKVFGRFPRVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRLKAGKD
RTGKVILSASQEGDHILLSIIDDGGGMDADKLRGIAVNRGLMDSDAASRLTNKECYNLIFAPGFSTKTEISDISGRGVGM
DVVKTAINQLNGSIDIDSNMGEGTKIVIKVPLTLAILPTLMVGVANQPFALPLASVNEIFHLDLSKTNIVDGQLTTIVRE
KSIPLFFLQDWLVPGSRQTERTGLGHVVIIQLGAQRVGFVVDTLIGQEEVVIKPLDELLQGTPGMAGATITSDGHIALIL
DVPNLLKRYAVRMR

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=727, Percent_Identity=33.0123796423659, Blast_Score=319, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 79052; Mature: 78921

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFEMDEDILQDFLIEAGEILELLSEQLVELEQRPDDADLLNAIFRGFHTVKGGAGFLSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHH
TELVDACHGAENVFDILRTGKRKVTSELMDTILQALDTVNVMFSSVQNGEALEPAEQSLL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DELHRLSKPASEDEIASAANEAVVEDIVIEESVIEVTPSVEEVSVSANNHDSVDDITEDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCHHCCHHH
FERLLDELHGKGASPSSAASVTPAPAAPIASSTSADDGDITDDEFERLLDELHGSGKSPS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
NATTTPAAKPVEDILSNSGDSDLMTDDEFEKLLDQLHGSGKGPTEEELDQAVQPVAAMNQ
CCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
TTSAPAPVVEAPTRTTAPAPTRTQAPKEDVKAVAKAPAKAPAKSQSESTVRVDTSTLDNI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHH
MNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAVMKTRMQPIKKVFGRFP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRLKAGK
HHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
DRTGKVILSASQEGDHILLSIIDDGGGMDADKLRGIAVNRGLMDSDAASRLTNKECYNLI
CCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHCCHHHHEEE
FAPGFSTKTEISDISGRGVGMDVVKTAINQLNGSIDIDSNMGEGTKIVIKVPLTLAILPT
EECCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCHHHHHHHH
LMVGVANQPFALPLASVNEIFHLDLSKTNIVDGQLTTIVREKSIPLFFLQDWLVPGSRQT
HHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCCCCC
ERTGLGHVVIIQLGAQRVGFVVDTLIGQEEVVIKPLDELLQGTPGMAGATITSDGHIALI
HHCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEE
LDVPNLLKRYAVRMR
ECCHHHHHHHHHCCC
>Mature Secondary Structure 
SFEMDEDILQDFLIEAGEILELLSEQLVELEQRPDDADLLNAIFRGFHTVKGGAGFLSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHH
TELVDACHGAENVFDILRTGKRKVTSELMDTILQALDTVNVMFSSVQNGEALEPAEQSLL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
DELHRLSKPASEDEIASAANEAVVEDIVIEESVIEVTPSVEEVSVSANNHDSVDDITEDE
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCCCCHHCCHHH
FERLLDELHGKGASPSSAASVTPAPAAPIASSTSADDGDITDDEFERLLDELHGSGKSPS
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
NATTTPAAKPVEDILSNSGDSDLMTDDEFEKLLDQLHGSGKGPTEEELDQAVQPVAAMNQ
CCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
TTSAPAPVVEAPTRTTAPAPTRTQAPKEDVKAVAKAPAKAPAKSQSESTVRVDTSTLDNI
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHH
MNMVGELVLVRNRLVSLGLNSNDEEMSKAVSNLDVVTADLQGAVMKTRMQPIKKVFGRFP
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHH
RVVRDLARTLKKDIVLEMRGEETDLDKNLVEALADPLIHLVRNSVDHGIEMPDDRLKAGK
HHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCC
DRTGKVILSASQEGDHILLSIIDDGGGMDADKLRGIAVNRGLMDSDAASRLTNKECYNLI
CCCCEEEEEECCCCCEEEEEEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHCCHHHHEEE
FAPGFSTKTEISDISGRGVGMDVVKTAINQLNGSIDIDSNMGEGTKIVIKVPLTLAILPT
EECCCCCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEEECCHHHHHHHH
LMVGVANQPFALPLASVNEIFHLDLSKTNIVDGQLTTIVREKSIPLFFLQDWLVPGSRQT
HHHHCCCCCCCCCHHHHHHHEEEECCCCCCCCCHHHHHHHHCCCCEEEHHHHCCCCCCCC
ERTGLGHVVIIQLGAQRVGFVVDTLIGQEEVVIKPLDELLQGTPGMAGATITSDGHIALI
HHCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCEEECCCCEEEE
LDVPNLLKRYAVRMR
ECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3278311; 11677609 [H]