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The map label for this gene is sixA [H]

Identifier: 59712415

GI number: 59712415

Start: 2039153

End: 2039623

Strand: Reverse

Name: sixA [H]

Synonym: VF_1808

Alternate gene names: 59712415

Gene position: 2039623-2039153 (Counterclockwise)

Preceding gene: 59712417

Following gene: 59712413

Centisome position: 70.39

GC content: 40.55

Gene sequence:

>471_bases
ATGAAAGTATTCATAATGCGTCACGGTGAGGCTGAAGCTTATGCTCCTTCAGATGAAGAGCGTAATTTAACCGCTCATGG
CGAAAGCCAATCTGCGAAAATAGCGCAATGGCTGATGGCTGAACATAAGATACAGTTTGATTATGTCTTGGTTAGCCCTT
ATGTTCGAGCGCAACAAACGTGGAATACGATTAAGTCAATTTTGAATGTGGCGGACGCAAAAGTAGAAATATGTGAAGAT
ATTACTCCTTATGGCGACTCAGATGATGTGGTTGAGTATGTAAAAGCTTTGGGAAGTGTTGAGGATATTGAGAATATTTT
ATTAGTCTCTCACTTACCACTCGTTGGCTACCTTACTGCTGATTTTGTTCCGGGAATTATGCCTCCGATGTTCCCAACAT
CAGCAATGTCTTGTGTTGAATATTCATATACAACAGGGAAAAGTGAGTTACTTTGGTTGCAGCAACCATAA

Upstream 100 bases:

>100_bases
AATTATGGCGCTGATACCACAGACTAGCAAACTCTCTCTTTCCTATTTTTACTTTTGCTTGCTACTATTGTGAAGTTAGT
AATGATTTGAGAATGAATAA

Downstream 100 bases:

>100_bases
ATTCATATAGAAAACAGATGAAATAAAAAAGATCCCAGAGCTTAACGGCTGTGGGATCTTTTTTTATCTATCAGGTATTG
AGAGTAATACTAGAATGGCA

Product: phosphohistidine phosphatase

Products: NA

Alternate protein names: RX6 [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MKVFIMRHGEAEAYAPSDEERNLTAHGESQSAKIAQWLMAEHKIQFDYVLVSPYVRAQQTWNTIKSILNVADAKVEICED
ITPYGDSDDVVEYVKALGSVEDIENILLVSHLPLVGYLTADFVPGIMPPMFPTSAMSCVEYSYTTGKSELLWLQQP

Sequences:

>Translated_156_residues
MKVFIMRHGEAEAYAPSDEERNLTAHGESQSAKIAQWLMAEHKIQFDYVLVSPYVRAQQTWNTIKSILNVADAKVEICED
ITPYGDSDDVVEYVKALGSVEDIENILLVSHLPLVGYLTADFVPGIMPPMFPTSAMSCVEYSYTTGKSELLWLQQP
>Mature_156_residues
MKVFIMRHGEAEAYAPSDEERNLTAHGESQSAKIAQWLMAEHKIQFDYVLVSPYVRAQQTWNTIKSILNVADAKVEICED
ITPYGDSDDVVEYVKALGSVEDIENILLVSHLPLVGYLTADFVPGIMPPMFPTSAMSCVEYSYTTGKSELLWLQQP

Specific function: Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His- Asp phosphorelay [H]

COG id: COG2062

COG function: function code T; Phosphohistidine phosphatase SixA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sixA phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788681, Length=156, Percent_Identity=42.3076923076923, Blast_Score=121, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR004449 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: 3.1.3.- [C]

Molecular weight: Translated: 17488; Mature: 17488

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFIMRHGEAEAYAPSDEERNLTAHGESQSAKIAQWLMAEHKIQFDYVLVSPYVRAQQT
CEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCEEEEEEECCHHHHHHH
WNTIKSILNVADAKVEICEDITPYGDSDDVVEYVKALGSVEDIENILLVSHLPLVGYLTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
DFVPGIMPPMFPTSAMSCVEYSYTTGKSELLWLQQP
HHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKVFIMRHGEAEAYAPSDEERNLTAHGESQSAKIAQWLMAEHKIQFDYVLVSPYVRAQQT
CEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCEEEEEEECCHHHHHHH
WNTIKSILNVADAKVEICEDITPYGDSDDVVEYVKALGSVEDIENILLVSHLPLVGYLTA
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
DFVPGIMPPMFPTSAMSCVEYSYTTGKSELLWLQQP
HHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9489669; 9205837; 9278503 [H]