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The map label for this gene is fabF [H]

Identifier: 59712345

GI number: 59712345

Start: 1961839

End: 1963083

Strand: Reverse

Name: fabF [H]

Synonym: VF_1738

Alternate gene names: 59712345

Gene position: 1963083-1961839 (Counterclockwise)

Preceding gene: 59712346

Following gene: 59712344

Centisome position: 67.75

GC content: 43.69

Gene sequence:

>1245_bases
GTGTCCAAACGTCGTGTAGTTGTTACAGGCATGGGTATGCTAACACCGGTGGGTAACACTGTTGAAGCATCTTGGAAAGC
GCTGTTAGCAGGCCAAAGCGGTATCGTTAATATCGAACACTTTGACACCACTGAGTTTACTACTCGTTTTGCAGGTCTAG
TTCAAGACTTTAATGCTGAAGAGTACATGTCTAAGAAAGACGCTCGTAAGATGGATTTATTTATCCAATACGGCGTAGCT
GCTGGCATTCAGGCATTAGATGACTCGGGTTTTAAAGTTACTGAAGAAAATGCTCACCGTATCGGTGCAGCAATTGGTTC
AGGTATTGGTGGCCTTGGCTTAATTGAAGCTGGCTACAAAGCATTCAGTGAAAAAGGTCCTCGTAAGATCAGCCCGTTTT
TCGTGCCTTCTACAATCGTTAATATGATCGCAGGTCATATGTCGATTATTCGTGGTTTACGTGGTCCAAATATCGCAATT
TCAACTGCTTGTACTACAGGTCTTCATAATATTGGTCATGCTGCACGTATGATCGCTTATGGTGATGCTGATGCAATGCT
AGCTGGTGGTGCTGAGAAAGCATCTACAGAGCTAGGTATGGGTGGTTTTGGTGCAGCAAAAGCACTATCTACAAATAATG
AAAACCCTCAAGGCGCATCTCGTCCTTGGGACAAAAACCGTGATGGTTTTGTTCTAGGTGATGGTGCTGGCATGATGGTT
CTTGAAGAATATGAACACGCTAAAGCTCGTGGTGCTAAGATCTACTGTGAACTTGTAGGTTTTGGTATGAGTGGTGATGC
TTACCATATGACTTCGCCAACGCCAGATGGTTCTGGTGGTGCGTTAGCGATGGAAGCTGCGATGCGTGATGCTGGCGTAA
CTGGTGAACAAATCGGTTACGTAAATGCACACGGTACGTCTACTCCTGCTGGTGATGTAGCTGAAATTAAAGGCATTAAA
CGTGCTCTTGGTGAAGCTGGCTCTAAGCAAGTTTTAGTATCTTCAACAAAATCAATGACTGGTCACCTTTTAGGTGCTGC
AGGTTCTGTTGAAGCAATCATCACAGCGATGTCTTTGGTTGATCAAATCGTTCCACCAACAATCAACCTTGATGATCCTG
AAGAAGGTTTAGATATTGACCTTGTTCCACACACAGCTCGTAAAGTAACAGATATGGAATACGCAATCTGTAACTCATTC
GGTTTTGGTGGTACAAACGGTTCACTAATCTTCAAGAAAATGTAA

Upstream 100 bases:

>100_bases
GCACAGTAAGAAATACCCTCCAGGCGGTCATCTTGACCGCCTGAGTTTTTATACGCAACAAATCCCTATCTAATTTCAAT
TAATTCCGGAGAAATATATC

Downstream 100 bases:

>100_bases
TAACTTGTTTGTGAAGCTTAACTAGTTTCCAAGAGTCAGTTACACTTTAAAGGCGGTTTGATATTATATCAAACCGCCTT
TTTATTTATTAGTCTGTTGG

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSKRRVVVTGMGMLTPVGNTVEASWKALLAGQSGIVNIEHFDTTEFTTRFAGLVQDFNAEEYMSKKDARKMDLFIQYGVA
AGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGYKAFSEKGPRKISPFFVPSTIVNMIAGHMSIIRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQGASRPWDKNRDGFVLGDGAGMMV
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDAGVTGEQIGYVNAHGTSTPAGDVAEIKGIK
RALGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITAMSLVDQIVPPTINLDDPEEGLDIDLVPHTARKVTDMEYAICNSF
GFGGTNGSLIFKKM

Sequences:

>Translated_414_residues
MSKRRVVVTGMGMLTPVGNTVEASWKALLAGQSGIVNIEHFDTTEFTTRFAGLVQDFNAEEYMSKKDARKMDLFIQYGVA
AGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGYKAFSEKGPRKISPFFVPSTIVNMIAGHMSIIRGLRGPNIAI
STACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQGASRPWDKNRDGFVLGDGAGMMV
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDAGVTGEQIGYVNAHGTSTPAGDVAEIKGIK
RALGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITAMSLVDQIVPPTINLDDPEEGLDIDLVPHTARKVTDMEYAICNSF
GFGGTNGSLIFKKM
>Mature_413_residues
SKRRVVVTGMGMLTPVGNTVEASWKALLAGQSGIVNIEHFDTTEFTTRFAGLVQDFNAEEYMSKKDARKMDLFIQYGVAA
GIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGYKAFSEKGPRKISPFFVPSTIVNMIAGHMSIIRGLRGPNIAIS
TACTTGLHNIGHAARMIAYGDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQGASRPWDKNRDGFVLGDGAGMMVL
EEYEHAKARGAKIYCELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDAGVTGEQIGYVNAHGTSTPAGDVAEIKGIKR
ALGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITAMSLVDQIVPPTINLDDPEEGLDIDLVPHTARKVTDMEYAICNSFG
FGGTNGSLIFKKM

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=45.9134615384615, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI223972627, Length=152, Percent_Identity=50, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI41872631, Length=423, Percent_Identity=24.3498817966903, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=74.1545893719807, Blast_Score=599, Evalue=1e-173,
Organism=Escherichia coli, GI1788663, Length=419, Percent_Identity=36.7541766109785, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=38.5542168674699, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=43.4456928838951, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=24.220623501199, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI212642053, Length=424, Percent_Identity=23.3490566037736, Blast_Score=107, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=38.9140271493213, Blast_Score=282, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24644341, Length=428, Percent_Identity=43.4579439252336, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24581345, Length=361, Percent_Identity=24.0997229916898, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19920632, Length=428, Percent_Identity=23.1308411214953, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221330659, Length=428, Percent_Identity=23.1308411214953, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43207; Mature: 43076

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRRVVVTGMGMLTPVGNTVEASWKALLAGQSGIVNIEHFDTTEFTTRFAGLVQDFNAE
CCCCEEEEECCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHH
EYMSKKDARKMDLFIQYGVAAGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGYK
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHH
AFSEKGPRKISPFFVPSTIVNMIAGHMSIIRGLRGPNIAISTACTTGLHNIGHAARMIAY
HHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQGASRPWDKNRDGFVLGDGAGMMV
CCCCCEEECCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDAGVTGEQIGY
EHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCEEHHHHHHHHCCCCHHHEEE
VNAHGTSTPAGDVAEIKGIKRALGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITAMSLV
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHH
DQIVPPTINLDDPEEGLDIDLVPHTARKVTDMEYAICNSFGFGGTNGSLIFKKM
HHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SKRRVVVTGMGMLTPVGNTVEASWKALLAGQSGIVNIEHFDTTEFTTRFAGLVQDFNAE
CCCEEEEECCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCHH
EYMSKKDARKMDLFIQYGVAAGIQALDDSGFKVTEENAHRIGAAIGSGIGGLGLIEAGYK
HHHHHHCCHHHHHHEEHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCHHHHHHHHH
AFSEKGPRKISPFFVPSTIVNMIAGHMSIIRGLRGPNIAISTACTTGLHNIGHAARMIAY
HHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHEEEE
GDADAMLAGGAEKASTELGMGGFGAAKALSTNNENPQGASRPWDKNRDGFVLGDGAGMMV
CCCCCEEECCCHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAKARGAKIYCELVGFGMSGDAYHMTSPTPDGSGGALAMEAAMRDAGVTGEQIGY
EHHHHHHHHCCCEEEEEEEEECCCCCEEEECCCCCCCCCCEEHHHHHHHHCCCCHHHEEE
VNAHGTSTPAGDVAEIKGIKRALGEAGSKQVLVSSTKSMTGHLLGAAGSVEAIITAMSLV
EECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHH
DQIVPPTINLDDPEEGLDIDLVPHTARKVTDMEYAICNSFGFGGTNGSLIFKKM
HHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]