Click here to switch to the map view.

The map label for this gene is moeB [H]

Identifier: 59712216

GI number: 59712216

Start: 1805658

End: 1806407

Strand: Direct

Name: moeB [H]

Synonym: VF_1609

Alternate gene names: 59712216

Gene position: 1805658-1806407 (Clockwise)

Preceding gene: 59712215

Following gene: 59712217

Centisome position: 62.32

GC content: 40.4

Gene sequence:

>750_bases
ATGAGTGAATTAACTGATAATGAAATGCTTCGCTATAACCGTCAGATCATCTTACGTAATTTTGATTTTGATGGCCAAGA
AGCATTAAAAGCAAGCTCCATACTGATCATTGGTGCGGGAGGTCTGGGTTGCGCATCCAGTCAATATTTAGCAGCAGCGG
GGGTTGGTACTCTAACGCTTGTTGATGATGATACCGTTGAACTTTCAAACCTGCAACGTCAGGTATTGCACTGCGATGAG
ACCATCGGCGTAAAAAAAGTTATGTCAGCTAAAATGGCGTTAAATCGAATTAACCCTAATTGCCACATCAACACTGTAGA
TAAGCGTCTATCTGATGACGAATTGCGCTCATTCATTGCATCTCATGATCTAGTACTTGATGGTACTGATAATGTTGATA
CACGTAACCAATTAAACCGCTTATGCCACGAATCGAAGACACCATTGGTTTCTGGTGCAGCGATTCGTATGGAAGGCCAA
GTAAGTGTTTATACGTATCAAGATGATGAGCCTTGCTACCAATGCTTAAGCAGTTTATTTGGGCAACAAGCATTGACCTG
TGTTGAAGCAGGAGTAATGTCTCCTGTTGTCGGTATTATTGGTTCTGTTCAAGCATTAGAAGCGATAAAAGTATTAACTA
ACTATGGTCAACCTTTAATCAGCAAACTTCTTATTCTTGATGCCCTATCGATGAATTGGCGAGAAATGAAATTGGCTAAA
ATGCCTAATTGCTCAGTTTGCAGTCATTAA

Upstream 100 bases:

>100_bases
AATTGTTTTGTTGTATTAGAGCGTGAGCGTGGTCGCGTTGACGCGGGTGAAACGGTTAACATCGAACTTTTCAACGCATC
ACTATACTAAGAGCTTATTT

Downstream 100 bases:

>100_bases
ATACACGTTTATTTTCAATTTGAAGGCGATAAAAACACATGTTTTATCGCCTTTTTTTATTTCCTAAACACAAAAAAATC
CCCAATAAAAACAATAAGAA

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSELTDNEMLRYNRQIILRNFDFDGQEALKASSILIIGAGGLGCASSQYLAAAGVGTLTLVDDDTVELSNLQRQVLHCDE
TIGVKKVMSAKMALNRINPNCHINTVDKRLSDDELRSFIASHDLVLDGTDNVDTRNQLNRLCHESKTPLVSGAAIRMEGQ
VSVYTYQDDEPCYQCLSSLFGQQALTCVEAGVMSPVVGIIGSVQALEAIKVLTNYGQPLISKLLILDALSMNWREMKLAK
MPNCSVCSH

Sequences:

>Translated_249_residues
MSELTDNEMLRYNRQIILRNFDFDGQEALKASSILIIGAGGLGCASSQYLAAAGVGTLTLVDDDTVELSNLQRQVLHCDE
TIGVKKVMSAKMALNRINPNCHINTVDKRLSDDELRSFIASHDLVLDGTDNVDTRNQLNRLCHESKTPLVSGAAIRMEGQ
VSVYTYQDDEPCYQCLSSLFGQQALTCVEAGVMSPVVGIIGSVQALEAIKVLTNYGQPLISKLLILDALSMNWREMKLAK
MPNCSVCSH
>Mature_248_residues
SELTDNEMLRYNRQIILRNFDFDGQEALKASSILIIGAGGLGCASSQYLAAAGVGTLTLVDDDTVELSNLQRQVLHCDET
IGVKKVMSAKMALNRINPNCHINTVDKRLSDDELRSFIASHDLVLDGTDNVDTRNQLNRLCHESKTPLVSGAAIRMEGQV
SVYTYQDDEPCYQCLSSLFGQQALTCVEAGVMSPVVGIIGSVQALEAIKVLTNYGQPLISKLLILDALSMNWREMKLAKM
PNCSVCSH

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=234, Percent_Identity=40.5982905982906, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI4885649, Length=150, Percent_Identity=32, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI23510338, Length=162, Percent_Identity=30.2469135802469, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI23510340, Length=162, Percent_Identity=30.2469135802469, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI38045944, Length=170, Percent_Identity=28.2352941176471, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=65.863453815261, Blast_Score=345, Evalue=1e-96,
Organism=Escherichia coli, GI87082356, Length=244, Percent_Identity=41.8032786885246, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1789177, Length=131, Percent_Identity=29.7709923664122, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17540406, Length=240, Percent_Identity=39.1666666666667, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203301, Length=164, Percent_Identity=32.3170731707317, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71984476, Length=170, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86565433, Length=169, Percent_Identity=29.585798816568, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=169, Percent_Identity=29.585798816568, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=227, Percent_Identity=34.3612334801762, Blast_Score=138, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6322639, Length=164, Percent_Identity=29.8780487804878, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582879, Length=250, Percent_Identity=46, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24660640, Length=151, Percent_Identity=35.0993377483444, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573937, Length=161, Percent_Identity=31.6770186335404, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129973, Length=163, Percent_Identity=32.5153374233129, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 27242; Mature: 27110

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELTDNEMLRYNRQIILRNFDFDGQEALKASSILIIGAGGLGCASSQYLAAAGVGTLTL
CCCCCHHHHHHHCCEEEEEECCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCEEEE
VDDDTVELSNLQRQVLHCDETIGVKKVMSAKMALNRINPNCHINTVDKRLSDDELRSFIA
ECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHH
SHDLVLDGTDNVDTRNQLNRLCHESKTPLVSGAAIRMEGQVSVYTYQDDEPCYQCLSSLF
HCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECEEEEEEECCCCHHHHHHHHHH
GQQALTCVEAGVMSPVVGIIGSVQALEAIKVLTNYGQPLISKLLILDALSMNWREMKLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHC
MPNCSVCSH
CCCCCCCCC
>Mature Secondary Structure 
SELTDNEMLRYNRQIILRNFDFDGQEALKASSILIIGAGGLGCASSQYLAAAGVGTLTL
CCCCHHHHHHHCCEEEEEECCCCCHHHHHHCCEEEEECCCCCCCCCCHHHHCCCCEEEE
VDDDTVELSNLQRQVLHCDETIGVKKVMSAKMALNRINPNCHINTVDKRLSDDELRSFIA
ECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHH
SHDLVLDGTDNVDTRNQLNRLCHESKTPLVSGAAIRMEGQVSVYTYQDDEPCYQCLSSLF
HCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECEEEEEEECCCCHHHHHHHHHH
GQQALTCVEAGVMSPVVGIIGSVQALEAIKVLTNYGQPLISKLLILDALSMNWREMKLAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHC
MPNCSVCSH
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]