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The map label for this gene is moeA [H]

Identifier: 59712215

GI number: 59712215

Start: 1804403

End: 1805647

Strand: Direct

Name: moeA [H]

Synonym: VF_1608

Alternate gene names: 59712215

Gene position: 1804403-1805647 (Clockwise)

Preceding gene: 59712213

Following gene: 59712216

Centisome position: 62.27

GC content: 41.45

Gene sequence:

>1245_bases
ATGGATTGCTGCGCAACTCAAGGTTTAATTCCAGTAGAAACCGCTTTAGAAACCTTATTATCTCAAGTTTCTCCGGTATC
AAATACCCATTCTTTAGCTCTTGCTGATGCAATTGGCTTTGTATTAGCTGAAGATATTCGTTCTCCTATTAATGTTCCTC
CATTTGCTAACTCGGCAATGGATGGCTATGCGGTACGTATTGCTGATTTAGAGCAGTCATTAACTTTACCTGTCGCTGGT
AAATCTTTTGCAGGCATTCCTTTTGAAGGTGAATGGCAGCCACAAACCACTGTTCGTATTATGACTGGCGCTAAAATCCC
CGAGGGTTGCGATGCTGTCATTATGCAAGAACTAACCACTGAAACAGATGCAGGTATTACCTTCGAATTAAGCCTTGCTG
ATGTAAAACCGCAAGCAAACATCCGTCCGATTGGCGACGATGTATCTCAAGGCCAAACTGTACTAGCTAAAGGTCACCGT
TTAACACCACGTGATATCCCGTTAATTGCATCATTAGGTATTAATGATATTTCCGTAGTAGATAAGCCAAAAGTCGCTTT
CTTCTCTACTGGTGATGAACTTAAACCCCTTGGTCAACCACTAGAAGATGGTCAAATCTACGACAGTAATCGCTACGGTA
TTAAAGTATTAATTGAACGTTTTGGTTGTGAAGCGGTCGATCTCGGTATTATCCCTGACTGTCCAGAAACACTAAAAGAA
GTATTCCTAAAAGCAGATAAAGAAGCCGATGTGGTAATTACTTCTGGCGGTGTAAGTGTTGGCGAGGCAGATTATACTAA
AGATATTTTGGATGAATTAGGTCAGATCGGCTTTTGGAAATTAGCCATTAAACCAGGCAAACCTTTTGCTTTTGGTCAAT
TACCAAATTCTTACTTCTGTGGTTTACCTGGAAACCCAGTATCGGCAATGTTAACCATGTATGTACTTGTACAGCCAATG
CTTGCAAAGCTTGCGGGCCATACAAAGTGGGAAGCACCAAAATCAATTCCTGCAAAAGCAACATCTACATTTAAAAAACA
CCCTGGCCGTACTGACTATCAACGTGGCATTTATTCTATTAATGAACAAGGCCAATTTGAGGTATCGACGACCGGTAATC
AAGGTTCTGGTGCCTTCAGTTCAATGAGTATTGCCAATTGTTTTGTTGTATTAGAGCGTGAGCGTGGTCGCGTTGACGCG
GGTGAAACGGTTAACATCGAACTTTTCAACGCATCACTATACTAA

Upstream 100 bases:

>100_bases
TCAAATAAATACACCCTGATTTTACTAGGTCTATTAGATGTTAAAGGCCAAAATATGGTAATGTTCAATCATTATTACGA
TTAATGTAGAGAGTACCCTA

Downstream 100 bases:

>100_bases
GAGCTTATTTATGAGTGAATTAACTGATAATGAAATGCTTCGCTATAACCGTCAGATCATCTTACGTAATTTTGATTTTG
ATGGCCAAGAAGCATTAAAA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MDCCATQGLIPVETALETLLSQVSPVSNTHSLALADAIGFVLAEDIRSPINVPPFANSAMDGYAVRIADLEQSLTLPVAG
KSFAGIPFEGEWQPQTTVRIMTGAKIPEGCDAVIMQELTTETDAGITFELSLADVKPQANIRPIGDDVSQGQTVLAKGHR
LTPRDIPLIASLGINDISVVDKPKVAFFSTGDELKPLGQPLEDGQIYDSNRYGIKVLIERFGCEAVDLGIIPDCPETLKE
VFLKADKEADVVITSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPNSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHTKWEAPKSIPAKATSTFKKHPGRTDYQRGIYSINEQGQFEVSTTGNQGSGAFSSMSIANCFVVLERERGRVDA
GETVNIELFNASLY

Sequences:

>Translated_414_residues
MDCCATQGLIPVETALETLLSQVSPVSNTHSLALADAIGFVLAEDIRSPINVPPFANSAMDGYAVRIADLEQSLTLPVAG
KSFAGIPFEGEWQPQTTVRIMTGAKIPEGCDAVIMQELTTETDAGITFELSLADVKPQANIRPIGDDVSQGQTVLAKGHR
LTPRDIPLIASLGINDISVVDKPKVAFFSTGDELKPLGQPLEDGQIYDSNRYGIKVLIERFGCEAVDLGIIPDCPETLKE
VFLKADKEADVVITSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPNSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHTKWEAPKSIPAKATSTFKKHPGRTDYQRGIYSINEQGQFEVSTTGNQGSGAFSSMSIANCFVVLERERGRVDA
GETVNIELFNASLY
>Mature_414_residues
MDCCATQGLIPVETALETLLSQVSPVSNTHSLALADAIGFVLAEDIRSPINVPPFANSAMDGYAVRIADLEQSLTLPVAG
KSFAGIPFEGEWQPQTTVRIMTGAKIPEGCDAVIMQELTTETDAGITFELSLADVKPQANIRPIGDDVSQGQTVLAKGHR
LTPRDIPLIASLGINDISVVDKPKVAFFSTGDELKPLGQPLEDGQIYDSNRYGIKVLIERFGCEAVDLGIIPDCPETLKE
VFLKADKEADVVITSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPNSYFCGLPGNPVSAMLTMYVLVQPM
LAKLAGHTKWEAPKSIPAKATSTFKKHPGRTDYQRGIYSINEQGQFEVSTTGNQGSGAFSSMSIANCFVVLERERGRVDA
GETVNIELFNASLY

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=396, Percent_Identity=38.3838383838384, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI66932975, Length=396, Percent_Identity=38.3838383838384, Blast_Score=213, Evalue=4e-55,
Organism=Escherichia coli, GI1787049, Length=406, Percent_Identity=57.3891625615764, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI25147659, Length=311, Percent_Identity=32.475884244373, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=332, Percent_Identity=25.6024096385542, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17136978, Length=409, Percent_Identity=30.8068459657702, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24638841, Length=409, Percent_Identity=30.8068459657702, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44475; Mature: 44475

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCCATQGLIPVETALETLLSQVSPVSNTHSLALADAIGFVLAEDIRSPINVPPFANSAM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRIADLEQSLTLPVAGKSFAGIPFEGEWQPQTTVRIMTGAKIPEGCDAVIMQELTT
CCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHC
ETDAGITFELSLADVKPQANIRPIGDDVSQGQTVLAKGHRLTPRDIPLIASLGINDISVV
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEEC
DKPKVAFFSTGDELKPLGQPLEDGQIYDSNRYGIKVLIERFGCEAVDLGIIPDCPETLKE
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHH
VFLKADKEADVVITSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPNSYFC
HHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEC
GLPGNPVSAMLTMYVLVQPMLAKLAGHTKWEAPKSIPAKATSTFKKHPGRTDYQRGIYSI
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCEEE
NEQGQFEVSTTGNQGSGAFSSMSIANCFVVLERERGRVDAGETVNIELFNASLY
CCCCCEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MDCCATQGLIPVETALETLLSQVSPVSNTHSLALADAIGFVLAEDIRSPINVPPFANSAM
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DGYAVRIADLEQSLTLPVAGKSFAGIPFEGEWQPQTTVRIMTGAKIPEGCDAVIMQELTT
CCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHC
ETDAGITFELSLADVKPQANIRPIGDDVSQGQTVLAKGHRLTPRDIPLIASLGINDISVV
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEECCCCCEEEC
DKPKVAFFSTGDELKPLGQPLEDGQIYDSNRYGIKVLIERFGCEAVDLGIIPDCPETLKE
CCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCCHHHHHH
VFLKADKEADVVITSGGVSVGEADYTKDILDELGQIGFWKLAIKPGKPFAFGQLPNSYFC
HHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCEEC
GLPGNPVSAMLTMYVLVQPMLAKLAGHTKWEAPKSIPAKATSTFKKHPGRTDYQRGIYSI
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCEEE
NEQGQFEVSTTGNQGSGAFSSMSIANCFVVLERERGRVDAGETVNIELFNASLY
CCCCCEEEEECCCCCCCCHHHHHHEEEEEEEECCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]