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The map label for this gene is ppiB [H]

Identifier: 59712208

GI number: 59712208

Start: 1797246

End: 1797743

Strand: Direct

Name: ppiB [H]

Synonym: VF_1601

Alternate gene names: 59712208

Gene position: 1797246-1797743 (Clockwise)

Preceding gene: 59712205

Following gene: 59712209

Centisome position: 62.03

GC content: 40.16

Gene sequence:

>498_bases
ATGATCATCCTACATACATCATTTGGTGACATCACAGTTAAACTTCACGAAGACAAAGCACCAGCAACGTGTGCTAACTT
CCTACAATACTGTAAAGATGGTTTCTACGACAACACTCTTTTCCACCGTGTAATTGATGGTTTTATGGTTCAAGGTGGCG
GCATGACTTCAGGTCTTGAAGAAAAAACTGGCCGTGCAACTATCAAAAACGAAGCAAATAATGGCCTAAGCAACAAAGTA
GGTACATTAGCAATGGCTCGTACTATGGAACCGCATTCAGCAAGTTCTCAATTCTTCATCAACGTTAACGACAACAAATT
CCTAGATTTTAAATCTGAATCTCTAGATGGTTGGGGTTACTGTGTGTTTGCTGAAGTGGTTGAAGGCATGGACGTTGTAA
ACAAAATCAAAGGTGTTGCTACTGGTAACTACGGTTACGTACACCAAGATGTTCCTGTTGAAGAAGTATTCATCACAGGC
ACAACAATCACAGAATAA

Upstream 100 bases:

>100_bases
GACCTATATTAAGTGCTGATAGCAAGAAAATTCCCTGTAGATTCTGATTAATCTTAGGTAAAATCAAATTCTATTTAAAT
ACAATTACAAAGGTAATTCC

Downstream 100 bases:

>100_bases
TTCTGTTTTTTTGCCAGCTTTATTCAAAGCTGGCATTTTCTCATTACCAATAAAGTATTTATGACTATCTTATTTATTTC
TGATCTTCACTTATCCCCTC

Product: peptidyl-prolyl cis-trans isomerase B (rotamase B)

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MIILHTSFGDITVKLHEDKAPATCANFLQYCKDGFYDNTLFHRVIDGFMVQGGGMTSGLEEKTGRATIKNEANNGLSNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESLDGWGYCVFAEVVEGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE

Sequences:

>Translated_165_residues
MIILHTSFGDITVKLHEDKAPATCANFLQYCKDGFYDNTLFHRVIDGFMVQGGGMTSGLEEKTGRATIKNEANNGLSNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESLDGWGYCVFAEVVEGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE
>Mature_165_residues
MIILHTSFGDITVKLHEDKAPATCANFLQYCKDGFYDNTLFHRVIDGFMVQGGGMTSGLEEKTGRATIKNEANNGLSNKV
GTLAMARTMEPHSASSQFFINVNDNKFLDFKSESLDGWGYCVFAEVVEGMDVVNKIKGVATGNYGYVHQDVPVEEVFITG
TTITE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=165, Percent_Identity=35.1515151515151, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7657473, Length=165, Percent_Identity=35.1515151515151, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI22547215, Length=165, Percent_Identity=35.1515151515151, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=33.9393939393939, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI64276486, Length=105, Percent_Identity=43.8095238095238, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=31.7647058823529, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI24308049, Length=164, Percent_Identity=34.7560975609756, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI20911035, Length=178, Percent_Identity=32.0224719101124, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI27735045, Length=161, Percent_Identity=29.8136645962733, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI5454154, Length=147, Percent_Identity=34.6938775510204, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310110104, Length=141, Percent_Identity=36.1702127659575, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786736, Length=165, Percent_Identity=64.8484848484848, Blast_Score=230, Evalue=5e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=50, Blast_Score=160, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17539496, Length=165, Percent_Identity=35.1515151515151, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=37.7622377622378, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=33.7931034482759, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=145, Percent_Identity=33.7931034482759, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=33.125, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=164, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17551284, Length=164, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17552780, Length=159, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=166, Percent_Identity=31.9277108433735, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532643, Length=149, Percent_Identity=35.5704697986577, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539498, Length=141, Percent_Identity=34.7517730496454, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=141, Percent_Identity=35.4609929078014, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=158, Percent_Identity=37.3417721518987, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=157, Percent_Identity=32.484076433121, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=31.5151515151515, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=35.1515151515151, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI21355677, Length=170, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922912, Length=138, Percent_Identity=35.5072463768116, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=34.5679012345679, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357249, Length=102, Percent_Identity=37.2549019607843, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652460, Length=167, Percent_Identity=28.7425149700599, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18119; Mature: 18119

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILHTSFGDITVKLHEDKAPATCANFLQYCKDGFYDNTLFHRVIDGFMVQGGGMTSGLE
CEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCC
EKTGRATIKNEANNGLSNKVGTLAMARTMEPHSASSQFFINVNDNKFLDFKSESLDGWGY
CCCCCEEEECCCCCCCCCHHHHHHHHEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCE
CVFAEVVEGMDVVNKIKGVATGNYGYVHQDVPVEEVFITGTTITE
EHHHHHHHHHHHHHHHCCEECCCCCEEECCCCHHHEEEECCEECC
>Mature Secondary Structure
MIILHTSFGDITVKLHEDKAPATCANFLQYCKDGFYDNTLFHRVIDGFMVQGGGMTSGLE
CEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHEEECCCCCCCCC
EKTGRATIKNEANNGLSNKVGTLAMARTMEPHSASSQFFINVNDNKFLDFKSESLDGWGY
CCCCCEEEECCCCCCCCCHHHHHHHHEECCCCCCCCEEEEEECCCEEEEECCCCCCCCCE
CVFAEVVEGMDVVNKIKGVATGNYGYVHQDVPVEEVFITGTTITE
EHHHHHHHHHHHHHHHCCEECCCCCEEECCCCHHHEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]