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The map label for this gene is aslA [H]

Identifier: 59712037

GI number: 59712037

Start: 1584956

End: 1586527

Strand: Direct

Name: aslA [H]

Synonym: VF_1430

Alternate gene names: 59712037

Gene position: 1584956-1586527 (Clockwise)

Preceding gene: 59712036

Following gene: 59712039

Centisome position: 54.7

GC content: 41.92

Gene sequence:

>1572_bases
ATGGGTAATCATTTAAGTAAGATTGCTGTTGGAGTTGGTCTGCTTGCAACCTCTAGTGCAGCAATGGCAGCAGCGCAACC
TAACATACTTGCTATTTTTGGTGATGATGTTGGTTATTGGAACATTAGCGCCTACAACCAAGGAATGATGGGTTATAAAA
CACCTAACATCGATCGTATCGCGAATGAAGGTGCATTGTTCACTGATCACTATGGCCAACAATCTTGTACTGCTGGACGT
GCTGCTTTCATTACAGGTCAAGAACCTTTCCGTACGGGTCTATTAACCATTGGCATGCCAGGTTCTGATCATGGTATTCC
TGATTGGGCTCCAACCATTGCCGATCTTCTTAAAGATCAAGGCTACATGACGGCACAATTTGGTAAAAACCACCTTGGTG
ACCAAGATAAACATCTTCCAACCAATCACGGTTTTGACGAATTCTTCGGTAACCTTTACCACCTAAATGCCGAAGAAGAG
CCAGAAACTTACTACTACCCTAAAGATCCTGAGTTCCGTAAAAATTATGGTCCACGTGGTGTAATTAAATCTTATGCTGA
TGGTAAGATTGAAGATACCGGCCCAATGACTCGTAAGCGTATGGAGCACGCAGATGAAGAGTTCTTAGATTCTTCATTAG
CATTTATGGAAAAAGCGGTAAAAGCGGATAAACCTTTCTTTATCTGGCACAACACAACTCGCATGCACGTTTGGACTCGT
CTACAAGAAAAATACCAAGGTAAATCAGGCGTAAGTATTTATGCTGATGGTATGCTTGAGCACGATGACCAAGTTGGTAT
CCTACTTGATAAACTGGATGAGCTTGGTGTAGCAGATAACACGATCGTTATTTATTCAACCGATAACGGTGCAGAAACAG
TAACATGGCCTGACGGCGGTGCTACACCATTCTATGGTGAAAAAGGCACAACATGGGAAGGTGGTATGCGTGTACCACAA
CTTGTTCGTTGGCCGGGAACTATTAAACCTGGAACAAAAATCAATGAAATGATGGCGCACCAAGATTGGCTTCCAACTTT
ACTTGATGCTGCTGGTGTTCCAAACGTAAAAGAAAAACTTGCTAAAGGCTATAAAGCCAACGGTAAAGAGTTCAAAGTTC
ATATCGATGGTTACGATTTCAAACCATTCTTTGAAGGAAAAGTAGATAAAGGTCCTCGTGAATCACTGCTTTACTTCACT
GCAAATGGTGAGTTGAATGCCGTTCGCTGGCAAGATTGGAAACTGAACTTCGCAATAATGGAAGGTAATATTTCTGATGC
AGTTCGTTTGTCACCAAACTGGCCTCAAATCATCCACCTACGTGCGGACCCATTTGAAAAAGCACCGCATGAATCAGGCA
TGTACTTACGTTGGATGGCAGATAACATGTGGTTATTCGTACCAATGCAAGACGTATTAGCTGAGTTCTTTAATACTCTA
CCTGATTACCCAATGCAAATGAGTACTCAAATGAACCCTGCAGCTATCAGTGCACAATCACTTGGCTTAAAAGCGAAAAT
GCAACAGCTAGATAAGCTTCAAGCTCAAATGAATAAACTAAATGCTAAATAG

Upstream 100 bases:

>100_bases
ATAACTTTTGGTTATAAAGTCTATAAAGCGACGATTTAAAAATATTTATTTATGATCTCCGCGAATTAAACACGACTATA
ACTATTATTTGGAGTTATTT

Downstream 100 bases:

>100_bases
TAATATCTAAAACTAAAACGCCCCGAGTGAATATTCACTCGGGGCGTTTTTTTATCTGGAATCTAGCGACGCTGACAAGT
TGTGCAACCACGACACGCCG

Product: sulfatase family protein

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MGNHLSKIAVGVGLLATSSAAMAAAQPNILAIFGDDVGYWNISAYNQGMMGYKTPNIDRIANEGALFTDHYGQQSCTAGR
AAFITGQEPFRTGLLTIGMPGSDHGIPDWAPTIADLLKDQGYMTAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEE
PETYYYPKDPEFRKNYGPRGVIKSYADGKIEDTGPMTRKRMEHADEEFLDSSLAFMEKAVKADKPFFIWHNTTRMHVWTR
LQEKYQGKSGVSIYADGMLEHDDQVGILLDKLDELGVADNTIVIYSTDNGAETVTWPDGGATPFYGEKGTTWEGGMRVPQ
LVRWPGTIKPGTKINEMMAHQDWLPTLLDAAGVPNVKEKLAKGYKANGKEFKVHIDGYDFKPFFEGKVDKGPRESLLYFT
ANGELNAVRWQDWKLNFAIMEGNISDAVRLSPNWPQIIHLRADPFEKAPHESGMYLRWMADNMWLFVPMQDVLAEFFNTL
PDYPMQMSTQMNPAAISAQSLGLKAKMQQLDKLQAQMNKLNAK

Sequences:

>Translated_523_residues
MGNHLSKIAVGVGLLATSSAAMAAAQPNILAIFGDDVGYWNISAYNQGMMGYKTPNIDRIANEGALFTDHYGQQSCTAGR
AAFITGQEPFRTGLLTIGMPGSDHGIPDWAPTIADLLKDQGYMTAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEE
PETYYYPKDPEFRKNYGPRGVIKSYADGKIEDTGPMTRKRMEHADEEFLDSSLAFMEKAVKADKPFFIWHNTTRMHVWTR
LQEKYQGKSGVSIYADGMLEHDDQVGILLDKLDELGVADNTIVIYSTDNGAETVTWPDGGATPFYGEKGTTWEGGMRVPQ
LVRWPGTIKPGTKINEMMAHQDWLPTLLDAAGVPNVKEKLAKGYKANGKEFKVHIDGYDFKPFFEGKVDKGPRESLLYFT
ANGELNAVRWQDWKLNFAIMEGNISDAVRLSPNWPQIIHLRADPFEKAPHESGMYLRWMADNMWLFVPMQDVLAEFFNTL
PDYPMQMSTQMNPAAISAQSLGLKAKMQQLDKLQAQMNKLNAK
>Mature_522_residues
GNHLSKIAVGVGLLATSSAAMAAAQPNILAIFGDDVGYWNISAYNQGMMGYKTPNIDRIANEGALFTDHYGQQSCTAGRA
AFITGQEPFRTGLLTIGMPGSDHGIPDWAPTIADLLKDQGYMTAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEP
ETYYYPKDPEFRKNYGPRGVIKSYADGKIEDTGPMTRKRMEHADEEFLDSSLAFMEKAVKADKPFFIWHNTTRMHVWTRL
QEKYQGKSGVSIYADGMLEHDDQVGILLDKLDELGVADNTIVIYSTDNGAETVTWPDGGATPFYGEKGTTWEGGMRVPQL
VRWPGTIKPGTKINEMMAHQDWLPTLLDAAGVPNVKEKLAKGYKANGKEFKVHIDGYDFKPFFEGKVDKGPRESLLYFTA
NGELNAVRWQDWKLNFAIMEGNISDAVRLSPNWPQIIHLRADPFEKAPHESGMYLRWMADNMWLFVPMQDVLAEFFNTLP
DYPMQMSTQMNPAAISAQSLGLKAKMQQLDKLQAQMNKLNAK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=401, Percent_Identity=32.4189526184539, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229329, Length=401, Percent_Identity=32.4189526184539, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI6005990, Length=401, Percent_Identity=32.4189526184539, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229324, Length=401, Percent_Identity=32.4189526184539, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4503899, Length=479, Percent_Identity=29.6450939457203, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI45430057, Length=457, Percent_Identity=27.3522975929978, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI58743319, Length=454, Percent_Identity=28.8546255506608, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI146229327, Length=327, Percent_Identity=29.9694189602446, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI38569407, Length=390, Percent_Identity=31.025641025641, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI38569405, Length=390, Percent_Identity=31.025641025641, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI109389362, Length=422, Percent_Identity=27.7251184834123, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI53831991, Length=293, Percent_Identity=29.6928327645051, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI157266309, Length=163, Percent_Identity=38.6503067484663, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI59797060, Length=412, Percent_Identity=26.6990291262136, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI71852586, Length=151, Percent_Identity=35.7615894039735, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI71852584, Length=151, Percent_Identity=35.7615894039735, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI31742482, Length=164, Percent_Identity=36.5853658536585, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790233, Length=414, Percent_Identity=34.7826086956522, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI87081924, Length=426, Percent_Identity=23.7089201877934, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115533416, Length=443, Percent_Identity=26.1851015801354, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI115533418, Length=432, Percent_Identity=25.6944444444444, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559078, Length=283, Percent_Identity=28.2685512367491, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24666109, Length=419, Percent_Identity=28.1622911694511, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24666175, Length=403, Percent_Identity=26.5508684863524, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281366397, Length=413, Percent_Identity=26.8765133171913, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281366395, Length=413, Percent_Identity=26.8765133171913, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24666163, Length=413, Percent_Identity=26.8765133171913, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI281363223, Length=145, Percent_Identity=29.6551724137931, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58618; Mature: 58487

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNHLSKIAVGVGLLATSSAAMAAAQPNILAIFGDDVGYWNISAYNQGMMGYKTPNIDRI
CCCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHH
ANEGALFTDHYGQQSCTAGRAAFITGQEPFRTGLLTIGMPGSDHGIPDWAPTIADLLKDQ
HCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCC
GYMTAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEPETYYYPKDPEFRKNYGPRG
CCEEEECCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCEEECCCCCCHHHCCCCCH
VIKSYADGKIEDTGPMTRKRMEHADEEFLDSSLAFMEKAVKADKPFFIWHNTTRMHVWTR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEHHHHH
LQEKYQGKSGVSIYADGMLEHDDQVGILLDKLDELGVADNTIVIYSTDNGAETVTWPDGG
HHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCC
ATPFYGEKGTTWEGGMRVPQLVRWPGTIKPGTKINEMMAHQDWLPTLLDAAGVPNVKEKL
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AKGYKANGKEFKVHIDGYDFKPFFEGKVDKGPRESLLYFTANGELNAVRWQDWKLNFAIM
HCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECEEEEEEEE
EGNISDAVRLSPNWPQIIHLRADPFEKAPHESGMYLRWMADNMWLFVPMQDVLAEFFNTL
ECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHHHHHC
PDYPMQMSTQMNPAAISAQSLGLKAKMQQLDKLQAQMNKLNAK
CCCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GNHLSKIAVGVGLLATSSAAMAAAQPNILAIFGDDVGYWNISAYNQGMMGYKTPNIDRI
CCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCHHHH
ANEGALFTDHYGQQSCTAGRAAFITGQEPFRTGLLTIGMPGSDHGIPDWAPTIADLLKDQ
HCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCC
GYMTAQFGKNHLGDQDKHLPTNHGFDEFFGNLYHLNAEEEPETYYYPKDPEFRKNYGPRG
CCEEEECCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCEEECCCCCCHHHCCCCCH
VIKSYADGKIEDTGPMTRKRMEHADEEFLDSSLAFMEKAVKADKPFFIWHNTTRMHVWTR
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEHHHHH
LQEKYQGKSGVSIYADGMLEHDDQVGILLDKLDELGVADNTIVIYSTDNGAETVTWPDGG
HHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCC
ATPFYGEKGTTWEGGMRVPQLVRWPGTIKPGTKINEMMAHQDWLPTLLDAAGVPNVKEKL
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AKGYKANGKEFKVHIDGYDFKPFFEGKVDKGPRESLLYFTANGELNAVRWQDWKLNFAIM
HCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECEEEEEEEE
EGNISDAVRLSPNWPQIIHLRADPFEKAPHESGMYLRWMADNMWLFVPMQDVLAEFFNTL
ECCCCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHHHHHC
PDYPMQMSTQMNPAAISAQSLGLKAKMQQLDKLQAQMNKLNAK
CCCCCCCCCCCCCHHCCHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]