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The map label for this gene is aslA [H]

Identifier: 59712035

GI number: 59712035

Start: 1582251

End: 1583801

Strand: Direct

Name: aslA [H]

Synonym: VF_1428

Alternate gene names: 59712035

Gene position: 1582251-1583801 (Clockwise)

Preceding gene: 59712025

Following gene: 59712036

Centisome position: 54.61

GC content: 41.52

Gene sequence:

>1551_bases
ATGAACAAAATAGTAAAAAAAACCGCCATTGCAACAGGCCTTGCTTTATCAGGGATCCAAGTAGCTTATGCTGCTGCTCA
ACCGAATATCCTTGTCATTTTTGGTGATGATATTGGTTATGGAAACATCTCTGCTTATAACCAAGGTATGCTCGGCTACC
AAACGCCAAATATCGATAGCATTGCAAATGATGGGGCTCTCTTTACGTCTTATTACGGTCAACAATCTTGTACCGCTGGT
CGCTCAGCTTTCATCACTGGTCAAATGCCCGTCCGTACAGGTCTAACTAAAGTTGGATTACCAGGAGCAAAACAGGGTTT
ACAAGCACAAGACATCACTCTTGCTCAAACTTTAAAAGACCAAGGTTACGTTACTGGTCAATTTGGTAAAAACCACCTTG
GTGACCGCGATGACATGCTGCCAACCAACCATGGTTTTGATGAATTTTTTGGTAACCTTTACCACCTAAATGCAGAAGAA
GAACCAGAAAATGCAGACTACCCTAAAGACCCAACCTTCCGTAAAAACTTTGGGCCTCGTGGCGTTATTCATTCATACGC
AGATGGAAAAATTGAAGATACAGGTCCTCTAACTCGTAAACGCATGGAAACGGTTGATGAAGAAACGATGGATGCGGCGA
TGGACTTTATGACCAGAGCAGTAAAAGCAGACAAACCTTTCTTCACTTGGTACAACGCAACTCGAATGCATATCAAAACT
CACGTCAAAGCCGAGAATTCAGGAAAAACCGGACTTGGTGATTATGCAGATGGTATGGTTGAACATGACAACATTGTTGG
AGACCTACTTGATAAAGTCGATGATCTAGGCATCAGTGATAACACTGTCATCATTTACACAACCGATAACGGTCCAATGA
ATGCGACATGGCCTGATGCGGCCTTCAGTCCATTCCGTGGTGAGAAAAATACAGGTTGGGAAGGCGGTTTCCGTGTACCT
GCAGTCATTAAATGGCCTGGACACATCAAACCTGGCACAAAACTTAATGGCATGTTTGCTGGTGAAGACTGGCTACCAAC
ACTAACAGCAATCGCTGGTAATAAAGACATTAAGCAAGAGCTACTTAAAGGCTACAAAGCGGATAATGGCAAAACGTATA
AAAACCATCTAGACGGTTATAACCAAGTTAACTACCTAACAGGTAAATCAAAAGAAAGTGCTCGCCAAGAGTTCTTCTAC
TGGTCTGATGATGGTGAATTACTGGCTATGCGTGATGGTCGCTGGAAAATGCACTTCAAGATCCAAGAAAACCAAGGTTG
GAAAGTATGGACTCGTGAATTTACAAATCTACGTATTCCTATGATTTTCGATCTACAAGTAGATCCATACGAAAAAGCAG
ATCAAGGATTTGGATATGATTCATGGGTTTTTGATCATGTATTTTTGCTAGTCCCTACTCAAGCAAAAGTAGCAAAAATG
ATTGAAAGCTTTAAAGAGTTCCCACCACGTCAAGAAATTCCAAGCTTCTCTGTCGACAAAGTAATGGAACAGATGAAAAA
CATGGAAAAAGTAGCTAACGCTAGTAAATAA

Upstream 100 bases:

>100_bases
TAATAACCAATTTCAGTACATCGTTTTTTCCGTATTTGCAGGATAATGCAGATCCCTTTCCAATATTATCTAGCTGAAAT
CATTCCTTCAGGAGATAGCG

Downstream 100 bases:

>100_bases
CATGAATAAGATTTAGGGCTCATATGGGCCCTATTTTGCTATTTATAAGATACATAAAGGTGAAACCCATGCAGACAAAT
GCAGACTTTACATTTGATGA

Product: sulfatase family protein

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MNKIVKKTAIATGLALSGIQVAYAAAQPNILVIFGDDIGYGNISAYNQGMLGYQTPNIDSIANDGALFTSYYGQQSCTAG
RSAFITGQMPVRTGLTKVGLPGAKQGLQAQDITLAQTLKDQGYVTGQFGKNHLGDRDDMLPTNHGFDEFFGNLYHLNAEE
EPENADYPKDPTFRKNFGPRGVIHSYADGKIEDTGPLTRKRMETVDEETMDAAMDFMTRAVKADKPFFTWYNATRMHIKT
HVKAENSGKTGLGDYADGMVEHDNIVGDLLDKVDDLGISDNTVIIYTTDNGPMNATWPDAAFSPFRGEKNTGWEGGFRVP
AVIKWPGHIKPGTKLNGMFAGEDWLPTLTAIAGNKDIKQELLKGYKADNGKTYKNHLDGYNQVNYLTGKSKESARQEFFY
WSDDGELLAMRDGRWKMHFKIQENQGWKVWTREFTNLRIPMIFDLQVDPYEKADQGFGYDSWVFDHVFLLVPTQAKVAKM
IESFKEFPPRQEIPSFSVDKVMEQMKNMEKVANASK

Sequences:

>Translated_516_residues
MNKIVKKTAIATGLALSGIQVAYAAAQPNILVIFGDDIGYGNISAYNQGMLGYQTPNIDSIANDGALFTSYYGQQSCTAG
RSAFITGQMPVRTGLTKVGLPGAKQGLQAQDITLAQTLKDQGYVTGQFGKNHLGDRDDMLPTNHGFDEFFGNLYHLNAEE
EPENADYPKDPTFRKNFGPRGVIHSYADGKIEDTGPLTRKRMETVDEETMDAAMDFMTRAVKADKPFFTWYNATRMHIKT
HVKAENSGKTGLGDYADGMVEHDNIVGDLLDKVDDLGISDNTVIIYTTDNGPMNATWPDAAFSPFRGEKNTGWEGGFRVP
AVIKWPGHIKPGTKLNGMFAGEDWLPTLTAIAGNKDIKQELLKGYKADNGKTYKNHLDGYNQVNYLTGKSKESARQEFFY
WSDDGELLAMRDGRWKMHFKIQENQGWKVWTREFTNLRIPMIFDLQVDPYEKADQGFGYDSWVFDHVFLLVPTQAKVAKM
IESFKEFPPRQEIPSFSVDKVMEQMKNMEKVANASK
>Mature_516_residues
MNKIVKKTAIATGLALSGIQVAYAAAQPNILVIFGDDIGYGNISAYNQGMLGYQTPNIDSIANDGALFTSYYGQQSCTAG
RSAFITGQMPVRTGLTKVGLPGAKQGLQAQDITLAQTLKDQGYVTGQFGKNHLGDRDDMLPTNHGFDEFFGNLYHLNAEE
EPENADYPKDPTFRKNFGPRGVIHSYADGKIEDTGPLTRKRMETVDEETMDAAMDFMTRAVKADKPFFTWYNATRMHIKT
HVKAENSGKTGLGDYADGMVEHDNIVGDLLDKVDDLGISDNTVIIYTTDNGPMNATWPDAAFSPFRGEKNTGWEGGFRVP
AVIKWPGHIKPGTKLNGMFAGEDWLPTLTAIAGNKDIKQELLKGYKADNGKTYKNHLDGYNQVNYLTGKSKESARQEFFY
WSDDGELLAMRDGRWKMHFKIQENQGWKVWTREFTNLRIPMIFDLQVDPYEKADQGFGYDSWVFDHVFLLVPTQAKVAKM
IESFKEFPPRQEIPSFSVDKVMEQMKNMEKVANASK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=443, Percent_Identity=32.0541760722348, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI146229329, Length=443, Percent_Identity=32.0541760722348, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI6005990, Length=443, Percent_Identity=32.0541760722348, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI146229324, Length=443, Percent_Identity=32.0541760722348, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4503899, Length=512, Percent_Identity=28.3203125, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI45430057, Length=448, Percent_Identity=27.6785714285714, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI146229327, Length=371, Percent_Identity=29.6495956873315, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI53831991, Length=511, Percent_Identity=25.440313111546, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI157266309, Length=513, Percent_Identity=25.7309941520468, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI58743319, Length=450, Percent_Identity=25.7777777777778, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI31742482, Length=517, Percent_Identity=26.3056092843327, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38569405, Length=477, Percent_Identity=25.9958071278826, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI38569407, Length=352, Percent_Identity=28.9772727272727, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI59797060, Length=455, Percent_Identity=25.2747252747253, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI109389362, Length=132, Percent_Identity=37.8787878787879, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI71852586, Length=151, Percent_Identity=37.0860927152318, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI71852584, Length=151, Percent_Identity=37.0860927152318, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1790233, Length=493, Percent_Identity=32.0486815415822, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI87081924, Length=389, Percent_Identity=23.9074550128535, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533416, Length=425, Percent_Identity=27.0588235294118, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115533418, Length=406, Percent_Identity=26.8472906403941, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559078, Length=266, Percent_Identity=27.0676691729323, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281366397, Length=382, Percent_Identity=27.2251308900524, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI281366395, Length=382, Percent_Identity=27.2251308900524, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24666163, Length=382, Percent_Identity=27.2251308900524, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24666109, Length=419, Percent_Identity=27.2076372315036, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24666175, Length=371, Percent_Identity=27.4932614555256, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281363223, Length=459, Percent_Identity=25.9259259259259, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 57723; Mature: 57723

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIVKKTAIATGLALSGIQVAYAAAQPNILVIFGDDIGYGNISAYNQGMLGYQTPNIDS
CCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
IANDGALFTSYYGQQSCTAGRSAFITGQMPVRTGLTKVGLPGAKQGLQAQDITLAQTLKD
HCCCCCEEEECCCCCCCCCCCCEEEECCCCHHHCCHHCCCCCHHCCCCCCCHHHHHHHHH
QGYVTGQFGKNHLGDRDDMLPTNHGFDEFFGNLYHLNAEEEPENADYPKDPTFRKNFGPR
CCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
GVIHSYADGKIEDTGPLTRKRMETVDEETMDAAMDFMTRAVKADKPFFTWYNATRMHIKT
CCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
HVKAENSGKTGLGDYADGMVEHDNIVGDLLDKVDDLGISDNTVIIYTTDNGPMNATWPDA
EEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
AFSPFRGEKNTGWEGGFRVPAVIKWPGHIKPGTKLNGMFAGEDWLPTLTAIAGNKDIKQE
CCCCCCCCCCCCCCCCEECCEEEECCCCCCCCCCCCEEECCCCCCHHHHHHCCCHHHHHH
LLKGYKADNGKTYKNHLDGYNQVNYLTGKSKESARQEFFYWSDDGELLAMRDGRWKMHFK
HHHHCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHCEEECCCCCEEEEECCCEEEEEE
IQENQGWKVWTREFTNLRIPMIFDLQVDPYEKADQGFGYDSWVFDHVFLLVPTQAKVAKM
EECCCCCEEEEEHHCCEECCEEEEEECCCCHHHHCCCCCCHHHHCEEEEEECCHHHHHHH
IESFKEFPPRQEIPSFSVDKVMEQMKNMEKVANASK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKIVKKTAIATGLALSGIQVAYAAAQPNILVIFGDDIGYGNISAYNQGMLGYQTPNIDS
CCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHH
IANDGALFTSYYGQQSCTAGRSAFITGQMPVRTGLTKVGLPGAKQGLQAQDITLAQTLKD
HCCCCCEEEECCCCCCCCCCCCEEEECCCCHHHCCHHCCCCCHHCCCCCCCHHHHHHHHH
QGYVTGQFGKNHLGDRDDMLPTNHGFDEFFGNLYHLNAEEEPENADYPKDPTFRKNFGPR
CCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
GVIHSYADGKIEDTGPLTRKRMETVDEETMDAAMDFMTRAVKADKPFFTWYNATRMHIKT
CCEECCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEE
HVKAENSGKTGLGDYADGMVEHDNIVGDLLDKVDDLGISDNTVIIYTTDNGPMNATWPDA
EEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCC
AFSPFRGEKNTGWEGGFRVPAVIKWPGHIKPGTKLNGMFAGEDWLPTLTAIAGNKDIKQE
CCCCCCCCCCCCCCCCEECCEEEECCCCCCCCCCCCEEECCCCCCHHHHHHCCCHHHHHH
LLKGYKADNGKTYKNHLDGYNQVNYLTGKSKESARQEFFYWSDDGELLAMRDGRWKMHFK
HHHHCCCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHCEEECCCCCEEEEECCCEEEEEE
IQENQGWKVWTREFTNLRIPMIFDLQVDPYEKADQGFGYDSWVFDHVFLLVPTQAKVAKM
EECCCCCEEEEEHHCCEECCEEEEEECCCCHHHHCCCCCCHHHHCEEEEEECCHHHHHHH
IESFKEFPPRQEIPSFSVDKVMEQMKNMEKVANASK
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]