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The map label for this gene is aslA [H]

Identifier: 59712034

GI number: 59712034

Start: 1580479

End: 1582026

Strand: Reverse

Name: aslA [H]

Synonym: VF_1427

Alternate gene names: 59712034

Gene position: 1582026-1580479 (Counterclockwise)

Preceding gene: 172087709

Following gene: 59712033

Centisome position: 54.6

GC content: 39.99

Gene sequence:

>1548_bases
ATGGAAGTCAAAAAAGGAACGAAGCGTAGATTAACAATACTAAGTGCAGTGTTAATGGGAGCTTCGGGGTATACATTAGC
AGCAGAGAAGCCAAATATTCTGGTTATTTGGGGCGATGATATCGGTCAGTCTAATATCAGTGCGTATACTTTTGGTTTAA
TGGGATATAAAACACCAAATATCGATAGTATTGCTAAAGAAGGCATGATGTTTACTGATTATTATGGTGAGCAATCATGT
ACCGCTGGTCGATCAACTTTTATCACAGGACAAAGTGTTCTACGTACAGGTCTAAGTAAAGTTGGATTACCTGGTGCAGA
TATCGGTCTACAAGCTGAAGATGCAACGATCGCTGAAGTACTTAAACCTATGGGATACATGACAGGGCAATTTGGTAAAA
ACCACCTTGGTGATAAAGACGAATTCCTTCCTACAGCACATGGCTTTGACGAATTTTTTGGTAACCTTTACCACCTAAAT
GCTGAAGAAGAGCCTGAAAATATTGACTATCCAAAAGATCCTGAATTCCGCAAAAAATTTGGCCCTCGTGGTGTAATTAA
ATCTTTTGCTGATGGAAAAATTGAAGATACAGGTCCTCTAACTCGTAAGCGTATGGAAACGGTGGATGATGAAACGGTTT
CTGCAGCTATTGATTTTATGGGACGAGCGGTAAAAGCGGATAAGCCATTCTTTGTATGGTGGAACGCCACGCGTATGCAC
TTTAGAACTCACGTAAAACCTGAATTACAAGGTTCAACAGGCATTAGTAACTATGCTGATGGTATGGTTGAGCACGATAA
CCACGTTGGTGAACTTTTAAAAACAGTGGATAAACTAGGTATTAAAGATAACACCATTGTTTTCTATTCTACCGATAATG
GCCCTCATATGAACTCATGGCCGGATGCGGGTACAACCCCGTTCCGTAGTGAGAAAAATACAAACTGGGAAGGGGCATAT
CGTGTTCCTGCAATGGTGCGTTGGCCAGGAAAAATTGAACCAGGTGTAGTATCGAATGAAATTATGCACCACATGGATTG
GCTACCAACTTTTGCAGCAGCTGCTGGTAATGATCATATTAAAGATGATCTGAAAAAAGGAACAAAACTTGGTAATAAGA
GTTTTAAAAATCACTTAGATGGTTATAACTTCTTACCTTATTTAACGGGTAAAGAAAAAGAAGGCCGTCGTGAAGAAATT
TTCTACTTCACGGATGATGGTGATTTAGCTGCACTTCGTTATAACAAGTGGAAAGCCGTATTTATGGAGCAACGTGTGAA
GGGCACGCTTCAAATTTGGGCTGAACCGTTTGTAACATTACGTGTGCCTAAACTGTTTAACTTACGTATGGACCCATATG
AAGTCGCTGATGTAACGTCGAATACTTATTATGACTGGTTGTTAGACCACGCTTATATGTTCGTACCAGCGCAAGCTTAT
GTAGGAAAATACTTAGAAACATTTGAAGAATTCCCACCTCGTCAAAAAGCGGCAAGCTTCAGTCTTGATCAGGTAATGGA
AAAACTTCAACAGCCTCATAGTAAGTAA

Upstream 100 bases:

>100_bases
TTAAAAAGTAAAATTATTGTTGTATATTCCGTTGTTAGTTTTAGGTTTATGTACTATACCTTTAATGATGCTCTTTTTAT
CAATGGAAACAGGAGTTTAT

Downstream 100 bases:

>100_bases
CTTAATTTATCATGACAGTTCTAATTAAGAGGGCTCTTCGGAGCCCCTTTTTATATAAAAGCATTGCAATAGAAATTAAG
AGGGAACACGCAAAATCAAT

Product: acrylsulfatase-like enzyme

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MEVKKGTKRRLTILSAVLMGASGYTLAAEKPNILVIWGDDIGQSNISAYTFGLMGYKTPNIDSIAKEGMMFTDYYGEQSC
TAGRSTFITGQSVLRTGLSKVGLPGADIGLQAEDATIAEVLKPMGYMTGQFGKNHLGDKDEFLPTAHGFDEFFGNLYHLN
AEEEPENIDYPKDPEFRKKFGPRGVIKSFADGKIEDTGPLTRKRMETVDDETVSAAIDFMGRAVKADKPFFVWWNATRMH
FRTHVKPELQGSTGISNYADGMVEHDNHVGELLKTVDKLGIKDNTIVFYSTDNGPHMNSWPDAGTTPFRSEKNTNWEGAY
RVPAMVRWPGKIEPGVVSNEIMHHMDWLPTFAAAAGNDHIKDDLKKGTKLGNKSFKNHLDGYNFLPYLTGKEKEGRREEI
FYFTDDGDLAALRYNKWKAVFMEQRVKGTLQIWAEPFVTLRVPKLFNLRMDPYEVADVTSNTYYDWLLDHAYMFVPAQAY
VGKYLETFEEFPPRQKAASFSLDQVMEKLQQPHSK

Sequences:

>Translated_515_residues
MEVKKGTKRRLTILSAVLMGASGYTLAAEKPNILVIWGDDIGQSNISAYTFGLMGYKTPNIDSIAKEGMMFTDYYGEQSC
TAGRSTFITGQSVLRTGLSKVGLPGADIGLQAEDATIAEVLKPMGYMTGQFGKNHLGDKDEFLPTAHGFDEFFGNLYHLN
AEEEPENIDYPKDPEFRKKFGPRGVIKSFADGKIEDTGPLTRKRMETVDDETVSAAIDFMGRAVKADKPFFVWWNATRMH
FRTHVKPELQGSTGISNYADGMVEHDNHVGELLKTVDKLGIKDNTIVFYSTDNGPHMNSWPDAGTTPFRSEKNTNWEGAY
RVPAMVRWPGKIEPGVVSNEIMHHMDWLPTFAAAAGNDHIKDDLKKGTKLGNKSFKNHLDGYNFLPYLTGKEKEGRREEI
FYFTDDGDLAALRYNKWKAVFMEQRVKGTLQIWAEPFVTLRVPKLFNLRMDPYEVADVTSNTYYDWLLDHAYMFVPAQAY
VGKYLETFEEFPPRQKAASFSLDQVMEKLQQPHSK
>Mature_515_residues
MEVKKGTKRRLTILSAVLMGASGYTLAAEKPNILVIWGDDIGQSNISAYTFGLMGYKTPNIDSIAKEGMMFTDYYGEQSC
TAGRSTFITGQSVLRTGLSKVGLPGADIGLQAEDATIAEVLKPMGYMTGQFGKNHLGDKDEFLPTAHGFDEFFGNLYHLN
AEEEPENIDYPKDPEFRKKFGPRGVIKSFADGKIEDTGPLTRKRMETVDDETVSAAIDFMGRAVKADKPFFVWWNATRMH
FRTHVKPELQGSTGISNYADGMVEHDNHVGELLKTVDKLGIKDNTIVFYSTDNGPHMNSWPDAGTTPFRSEKNTNWEGAY
RVPAMVRWPGKIEPGVVSNEIMHHMDWLPTFAAAAGNDHIKDDLKKGTKLGNKSFKNHLDGYNFLPYLTGKEKEGRREEI
FYFTDDGDLAALRYNKWKAVFMEQRVKGTLQIWAEPFVTLRVPKLFNLRMDPYEVADVTSNTYYDWLLDHAYMFVPAQAY
VGKYLETFEEFPPRQKAASFSLDQVMEKLQQPHSK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=447, Percent_Identity=31.5436241610738, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229329, Length=447, Percent_Identity=31.5436241610738, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI6005990, Length=447, Percent_Identity=31.5436241610738, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI146229324, Length=447, Percent_Identity=31.5436241610738, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4503899, Length=416, Percent_Identity=30.7692307692308, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI45430057, Length=454, Percent_Identity=27.5330396475771, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI146229327, Length=373, Percent_Identity=30.5630026809651, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI157266309, Length=530, Percent_Identity=25.0943396226415, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI58743319, Length=505, Percent_Identity=25.1485148514851, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI109389362, Length=462, Percent_Identity=27.9220779220779, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI38569407, Length=354, Percent_Identity=28.2485875706215, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI71852584, Length=567, Percent_Identity=23.2804232804233, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI38569405, Length=354, Percent_Identity=28.2485875706215, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI59797060, Length=469, Percent_Identity=25.5863539445629, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI53831991, Length=222, Percent_Identity=27.4774774774775, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI31742482, Length=345, Percent_Identity=23.768115942029, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI71852586, Length=154, Percent_Identity=33.7662337662338, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790233, Length=493, Percent_Identity=30.2231237322515, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI87081924, Length=416, Percent_Identity=23.7980769230769, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533416, Length=430, Percent_Identity=26.046511627907, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI115533418, Length=410, Percent_Identity=25.1219512195122, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559078, Length=277, Percent_Identity=28.158844765343, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24666175, Length=443, Percent_Identity=27.313769751693, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24666109, Length=420, Percent_Identity=26.6666666666667, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI281366397, Length=431, Percent_Identity=27.8422273781903, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281366395, Length=431, Percent_Identity=27.8422273781903, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24666163, Length=431, Percent_Identity=27.8422273781903, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI281363223, Length=458, Percent_Identity=25.764192139738, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 58146; Mature: 58146

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVKKGTKRRLTILSAVLMGASGYTLAAEKPNILVIWGDDIGQSNISAYTFGLMGYKTPN
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCCC
IDSIAKEGMMFTDYYGEQSCTAGRSTFITGQSVLRTGLSKVGLPGADIGLQAEDATIAEV
HHHHHHCCCEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LKPMGYMTGQFGKNHLGDKDEFLPTAHGFDEFFGNLYHLNAEEEPENIDYPKDPEFRKKF
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHC
GPRGVIKSFADGKIEDTGPLTRKRMETVDDETVSAAIDFMGRAVKADKPFFVWWNATRMH
CCHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEE
FRTHVKPELQGSTGISNYADGMVEHDNHVGELLKTVDKLGIKDNTIVFYSTDNGPHMNSW
EEECCCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
PDAGTTPFRSEKNTNWEGAYRVPAMVRWPGKIEPGVVSNEIMHHMDWLPTFAAAAGNDHI
CCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
KDDLKKGTKLGNKSFKNHLDGYNFLPYLTGKEKEGRREEIFYFTDDGDLAALRYNKWKAV
HHHHHHHHHCCCHHHHHHCCCCCCCCEECCCCCCCCCEEEEEEECCCCEEEEEECCHHHH
FMEQRVKGTLQIWAEPFVTLRVPKLFNLRMDPYEVADVTSNTYYDWLLDHAYMFVPAQAY
HHHHHHHHHHEEECCCCEEEECCHHHCCCCCCHHHHHCCCCCHHHHHHHHHHEEEEHHHH
VGKYLETFEEFPPRQKAASFSLDQVMEKLQQPHSK
HHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MEVKKGTKRRLTILSAVLMGASGYTLAAEKPNILVIWGDDIGQSNISAYTFGLMGYKTPN
CCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECCCCCCC
IDSIAKEGMMFTDYYGEQSCTAGRSTFITGQSVLRTGLSKVGLPGADIGLQAEDATIAEV
HHHHHHCCCEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
LKPMGYMTGQFGKNHLGDKDEFLPTAHGFDEFFGNLYHLNAEEEPENIDYPKDPEFRKKF
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHC
GPRGVIKSFADGKIEDTGPLTRKRMETVDDETVSAAIDFMGRAVKADKPFFVWWNATRMH
CCHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEECCCEEE
FRTHVKPELQGSTGISNYADGMVEHDNHVGELLKTVDKLGIKDNTIVFYSTDNGPHMNSW
EEECCCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCC
PDAGTTPFRSEKNTNWEGAYRVPAMVRWPGKIEPGVVSNEIMHHMDWLPTFAAAAGNDHI
CCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHH
KDDLKKGTKLGNKSFKNHLDGYNFLPYLTGKEKEGRREEIFYFTDDGDLAALRYNKWKAV
HHHHHHHHHCCCHHHHHHCCCCCCCCEECCCCCCCCCEEEEEEECCCCEEEEEECCHHHH
FMEQRVKGTLQIWAEPFVTLRVPKLFNLRMDPYEVADVTSNTYYDWLLDHAYMFVPAQAY
HHHHHHHHHHEEECCCCEEEECCHHHCCCCCCHHHHHCCCCCHHHHHHHHHHEEEEHHHH
VGKYLETFEEFPPRQKAASFSLDQVMEKLQQPHSK
HHHHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]