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The map label for this gene is ribC [H]

Identifier: 59712021

GI number: 59712021

Start: 1564595

End: 1565203

Strand: Reverse

Name: ribC [H]

Synonym: VF_1414

Alternate gene names: 59712021

Gene position: 1565203-1564595 (Counterclockwise)

Preceding gene: 59712023

Following gene: 59712019

Centisome position: 54.02

GC content: 37.11

Gene sequence:

>609_bases
ATGTTTACAGGTATTGTCGCGACCACTGCAAAAGTCGTTAATATTGTAAAAAAAGACAAGTTTCAAACTCATATTATTGA
AATTCCTACTCCGTACCATCAAGGTTTAGAAATTGGTGCTTCAGTTGCTCATAATGGTTGTTGTTTGACCGTAACTAAGA
TTGAAGGCCAACAAGCGCACTTTGACCTTATCGAGGAAACGTTACGTTTAACGAATCTTGGTTTATTAGAAGTAGGGCAA
AAGGTTAATATTGAACGTGCAGCTCGCTTTGGAGATGAGATTGGTGGGCACTCAATGTCTGGCCATATCGTTGATGTAAT
GGTTGTACGTGAAATTAATAAAACCAGTGAGAATTGCCAAATATGGTTTGATGTTCCTGCACAATGGACAAAATACATTT
TACATAAAGGCTATATTGGGGTTGATGGGATCAGTTTGACGATTGGTGATGTCGATGAAAAAGGATTTAATGTAAATTTA
ATCCCTGAAACTCTAGAGCGTACCAATTTAAGTACTAGAATAATTGGCGATAAAATTAATCTAGAGATTGATCCGCAAAC
ACAAGCGATTGTAGATACTGTTGAGCGAGTGTTAGCGAACCAACAATAA

Upstream 100 bases:

>100_bases
TTCACAAAATGAAATATTCCAAGTATTGTAGATTATTGTAATAAAGTTGAGTTAATTATTTATAGTTCAAATGCTTGATA
AAAGATTATTGGAGAAGCAA

Downstream 100 bases:

>100_bases
GATCAGCTAAAACAATCCATCTTCATCATTATTGATAGAAAGACTTACCGATTGAGTATATGGGTTAATCTCCATGTTAA
ATTCAATGGCACGATGACAA

Product: riboflavin synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFTGIVATTAKVVNIVKKDKFQTHIIEIPTPYHQGLEIGASVAHNGCCLTVTKIEGQQAHFDLIEETLRLTNLGLLEVGQ
KVNIERAARFGDEIGGHSMSGHIVDVMVVREINKTSENCQIWFDVPAQWTKYILHKGYIGVDGISLTIGDVDEKGFNVNL
IPETLERTNLSTRIIGDKINLEIDPQTQAIVDTVERVLANQQ

Sequences:

>Translated_202_residues
MFTGIVATTAKVVNIVKKDKFQTHIIEIPTPYHQGLEIGASVAHNGCCLTVTKIEGQQAHFDLIEETLRLTNLGLLEVGQ
KVNIERAARFGDEIGGHSMSGHIVDVMVVREINKTSENCQIWFDVPAQWTKYILHKGYIGVDGISLTIGDVDEKGFNVNL
IPETLERTNLSTRIIGDKINLEIDPQTQAIVDTVERVLANQQ
>Mature_202_residues
MFTGIVATTAKVVNIVKKDKFQTHIIEIPTPYHQGLEIGASVAHNGCCLTVTKIEGQQAHFDLIEETLRLTNLGLLEVGQ
KVNIERAARFGDEIGGHSMSGHIVDVMVVREINKTSENCQIWFDVPAQWTKYILHKGYIGVDGISLTIGDVDEKGFNVNL
IPETLERTNLSTRIIGDKINLEIDPQTQAIVDTVERVLANQQ

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyze

COG id: COG0307

COG function: function code H; Riboflavin synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 lumazine-binding repeats [H]

Homologues:

Organism=Escherichia coli, GI1787952, Length=203, Percent_Identity=61.0837438423645, Blast_Score=248, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319733, Length=171, Percent_Identity=32.1637426900585, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001783
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00677 Lum_binding [H]

EC number: =2.5.1.9 [H]

Molecular weight: Translated: 22388; Mature: 22388

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00693 LUM_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTGIVATTAKVVNIVKKDKFQTHIIEIPTPYHQGLEIGASVAHNGCCLTVTKIEGQQAH
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCHHHHHHHCCCCEEEEEEECCCCCHH
FDLIEETLRLTNLGLLEVGQKVNIERAARFGDEIGGHSMSGHIVDVMVVREINKTSENCQ
HHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEHHCCCCCCCE
IWFDVPAQWTKYILHKGYIGVDGISLTIGDVDEKGFNVNLIPETLERTNLSTRIIGDKIN
EEEECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEECHHHHHHCCCEEEEECCEEE
LEIDPQTQAIVDTVERVLANQQ
EEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTGIVATTAKVVNIVKKDKFQTHIIEIPTPYHQGLEIGASVAHNGCCLTVTKIEGQQAH
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHCHHHHHHHCCCCEEEEEEECCCCCHH
FDLIEETLRLTNLGLLEVGQKVNIERAARFGDEIGGHSMSGHIVDVMVVREINKTSENCQ
HHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEHHCCCCCCCE
IWFDVPAQWTKYILHKGYIGVDGISLTIGDVDEKGFNVNLIPETLERTNLSTRIIGDKIN
EEEECCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEECHHHHHHCCCEEEEECCEEE
LEIDPQTQAIVDTVERVLANQQ
EEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9022701; 9023191; 9097039; 9278503; 11377200 [H]