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The map label for this gene is cobB [H]

Identifier: 59711927

GI number: 59711927

Start: 1468630

End: 1469343

Strand: Reverse

Name: cobB [H]

Synonym: VF_1320

Alternate gene names: 59711927

Gene position: 1469343-1468630 (Counterclockwise)

Preceding gene: 59711930

Following gene: 59711921

Centisome position: 50.71

GC content: 40.2

Gene sequence:

>714_bases
ATGTTATTTCCGTATAAGAATATCGTAATTTTAACTGGTGCTGGGATATCGGCTGAGTCGGGGATCCAAACTTTTCGTGC
TAGTGACGGGTTATGGGAAAACCATCGAATTGAAGACGTTGCAACACCAGAAGGTTTTTTGAATGACCCGGATTTAGTGC
AGGATTTCTATAATAAACGTAGAGCTCTGTTGAAAAGCGATAATATTCAACCTAACGCAGCCCATAAAGCACTCGCTAAA
CTTGAAAAAGAGTTGGATGGTACGGTGACAATCGTGACTCAGAATATTGATAATCTACATGAGCGCGGTGGAAGCACAAA
TGTGATTCATATGCATGGTGAGTTAAACAAGATTCGTTGTGAAGAATCGAATCAAGTGTTTGAGTGTACTGATGATATTC
ATACTGGTGATTTTTGTCATTGTTGCCAAATACCAGCTCAGTTACGTCCTCATGTCGTATGGTTTGGTGAAATGCCATTA
GAAATGGGCAGAATCCATGAAGCGTTAAATCAGGCGGATTTATTTATTTCGATTGGTACGTCAGGTTCAGTTTATCCAGC
TGCTGGCTTTGTGCATGAAGCTCGTTTACATGGCGCACATACTATTGAGATTAACTTGGAGCCAAGTGCTGTAGATGATG
AATTTGAAGAGAAACGTTATGGTAAAGCGGGTGAGTTAGTACCTGAGTTGGTTTCGGAACTATTAGAAATATAA

Upstream 100 bases:

>100_bases
GAATAAAGTAGCTTAGGTGTTTGTTTTTGGTATCCATAGAAACTGTAATGTTATTCATGGTAGAGTTTCAGCAAGAATCA
AATTGATTAAGGATGATGTC

Downstream 100 bases:

>100_bases
CTTTTAAAAAATAAAAAAAGCCAATAAATCATTAGATTCATTGGCTTTTAAATGTGTTGTATTACGATGTAATAGATGGG
TATTACATATCAACTTTTAG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MLFPYKNIVILTGAGISAESGIQTFRASDGLWENHRIEDVATPEGFLNDPDLVQDFYNKRRALLKSDNIQPNAAHKALAK
LEKELDGTVTIVTQNIDNLHERGGSTNVIHMHGELNKIRCEESNQVFECTDDIHTGDFCHCCQIPAQLRPHVVWFGEMPL
EMGRIHEALNQADLFISIGTSGSVYPAAGFVHEARLHGAHTIEINLEPSAVDDEFEEKRYGKAGELVPELVSELLEI

Sequences:

>Translated_237_residues
MLFPYKNIVILTGAGISAESGIQTFRASDGLWENHRIEDVATPEGFLNDPDLVQDFYNKRRALLKSDNIQPNAAHKALAK
LEKELDGTVTIVTQNIDNLHERGGSTNVIHMHGELNKIRCEESNQVFECTDDIHTGDFCHCCQIPAQLRPHVVWFGEMPL
EMGRIHEALNQADLFISIGTSGSVYPAAGFVHEARLHGAHTIEINLEPSAVDDEFEEKRYGKAGELVPELVSELLEI
>Mature_237_residues
MLFPYKNIVILTGAGISAESGIQTFRASDGLWENHRIEDVATPEGFLNDPDLVQDFYNKRRALLKSDNIQPNAAHKALAK
LEKELDGTVTIVTQNIDNLHERGGSTNVIHMHGELNKIRCEESNQVFECTDDIHTGDFCHCCQIPAQLRPHVVWFGEMPL
EMGRIHEALNQADLFISIGTSGSVYPAAGFVHEARLHGAHTIEINLEPSAVDDEFEEKRYGKAGELVPELVSELLEI

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=37.7118644067797, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI6912664, Length=254, Percent_Identity=35.8267716535433, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI13787215, Length=237, Percent_Identity=36.7088607594937, Blast_Score=146, Evalue=1e-35,
Organism=Homo sapiens, GI7657575, Length=223, Percent_Identity=29.5964125560538, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI6912660, Length=200, Percent_Identity=28, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI308199517, Length=230, Percent_Identity=68.2608695652174, Blast_Score=333, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17541892, Length=200, Percent_Identity=29.5, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28571445, Length=189, Percent_Identity=29.1005291005291, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137536, Length=222, Percent_Identity=27.4774774774775, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26397; Mature: 26397

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFPYKNIVILTGAGISAESGIQTFRASDGLWENHRIEDVATPEGFLNDPDLVQDFYNKR
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RALLKSDNIQPNAAHKALAKLEKELDGTVTIVTQNIDNLHERGGSTNVIHMHGELNKIRC
HHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCEEEECCCCCEEEE
EESNQVFECTDDIHTGDFCHCCQIPAQLRPHVVWFGEMPLEMGRIHEALNQADLFISIGT
CCCCCEEEECCCCCCCCCHHHHCCCHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECC
SGSVYPAAGFVHEARLHGAHTIEINLEPSAVDDEFEEKRYGKAGELVPELVSELLEI
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLFPYKNIVILTGAGISAESGIQTFRASDGLWENHRIEDVATPEGFLNDPDLVQDFYNKR
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RALLKSDNIQPNAAHKALAKLEKELDGTVTIVTQNIDNLHERGGSTNVIHMHGELNKIRC
HHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHCCCCCCEEEECCCCCEEEE
EESNQVFECTDDIHTGDFCHCCQIPAQLRPHVVWFGEMPLEMGRIHEALNQADLFISIGT
CCCCCEEEECCCCCCCCCHHHHCCCHHCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECC
SGSVYPAAGFVHEARLHGAHTIEINLEPSAVDDEFEEKRYGKAGELVPELVSELLEI
CCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA