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The map label for this gene is fabA [H]

Identifier: 59711899

GI number: 59711899

Start: 1442693

End: 1443211

Strand: Reverse

Name: fabA [H]

Synonym: VF_1292

Alternate gene names: 59711899

Gene position: 1443211-1442693 (Counterclockwise)

Preceding gene: 59711900

Following gene: 59711884

Centisome position: 49.81

GC content: 42.77

Gene sequence:

>519_bases
ATGCAAAACAAACCTAGTTCTTATGATCGCGAAGATTTACTAGCATCAAGCCGTGGCGAATTATTTGGCCCAAATGGTCC
ACAACTACCAGCACCAAACATGCTAATGATGGATCGTATCCCTCTGATGTCTGAAACTGAAGGCGCATTTGGTAAAGGTA
AAGTGATCGCAGAGTTAGATATTACTCCAGATCTTTGGTTCTTTGATTGTCACTTCCCTGGCGACCCAGTAATGCCTGGC
TGTCTTGGCCTTGATGCTATGTGGCAATTAGTTGGTTTCTTCCTTGGCTGGATTGGCGGCGAAGGTAAAGGTCGAGCTTT
AGGTGTGGGTGAAGTTAAATTCACAGGCCAAGTACTTCCTACTGCGAAAAAAGTAACTTACGAAATCGATTTCAAACGTG
TTATTAACCGTAAACTGGTTATGGGCCTAGCTGATGGTCGTGTACTTGTTGATGGTAAAGAAATCTACGTTGCAAAAGAC
CTTAAAGTTGGTCTTTTCCAAGATACATCTGCATTCTAA

Upstream 100 bases:

>100_bases
TATGTCGAATTAAACACTGGTTTAACCAGCGCTGATCCGACTTGATATGAGTACAAGTGTTAGCTAGAATTTCTGCAACT
TATTTAGGAGTAATACTTTA

Downstream 100 bases:

>100_bases
TTAAATTTTTTAGAATGATTAAAAGCTAGCTTCGTGCTAGCTTTTTTTATCGCCCTTCCCATAAGTTATAGTGCGTTAGT
ACTGTTTTATAACATATGTT

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase [H]

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MQNKPSSYDREDLLASSRGELFGPNGPQLPAPNMLMMDRIPLMSETEGAFGKGKVIAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWIGGEGKGRALGVGEVKFTGQVLPTAKKVTYEIDFKRVINRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF

Sequences:

>Translated_172_residues
MQNKPSSYDREDLLASSRGELFGPNGPQLPAPNMLMMDRIPLMSETEGAFGKGKVIAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWIGGEGKGRALGVGEVKFTGQVLPTAKKVTYEIDFKRVINRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF
>Mature_172_residues
MQNKPSSYDREDLLASSRGELFGPNGPQLPAPNMLMMDRIPLMSETEGAFGKGKVIAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWIGGEGKGRALGVGEVKFTGQVLPTAKKVTYEIDFKRVINRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP [H]

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787187, Length=172, Percent_Identity=80.2325581395349, Blast_Score=284, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114 [H]

Pfam domain/function: PF07977 FabA [H]

EC number: =4.2.1.60 [H]

Molecular weight: Translated: 18859; Mature: 18859

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKPSSYDREDLLASSRGELFGPNGPQLPAPNMLMMDRIPLMSETEGAFGKGKVIAELD
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEE
ITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWIGGEGKGRALGVGEVKFTGQVLP
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCEEECCEECC
TAKKVTYEIDFKRVINRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
CCEEEEEEEHHHHHHCHHEEEEECCCEEEEECCEEEEEECCEEEEECCCCCC
>Mature Secondary Structure
MQNKPSSYDREDLLASSRGELFGPNGPQLPAPNMLMMDRIPLMSETEGAFGKGKVIAELD
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEE
ITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWIGGEGKGRALGVGEVKFTGQVLP
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCEEECCEECC
TAKKVTYEIDFKRVINRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
CCEEEEEEEHHHHHHCHHEEEEECCCEEEEECCEEEEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA