Click here to switch to the map view.

The map label for this gene is pphA [H]

Identifier: 59711856

GI number: 59711856

Start: 1389615

End: 1390529

Strand: Direct

Name: pphA [H]

Synonym: VF_1249

Alternate gene names: 59711856

Gene position: 1389615-1390529 (Clockwise)

Preceding gene: 59711854

Following gene: 59711857

Centisome position: 47.96

GC content: 32.9

Gene sequence:

>915_bases
ATGAAAAATAATGACATAAAACTATCGATTCCTAACATTAGACGTTCAAGATTAATAAATGTAATAAAATCGCATGGTTG
CATCAGAATATTAGAAACTCATAATCCAATCTCAGCACTTATAGCAGAGAAAGCCAGTGCTAATGATATTGATTCTGAAG
AGAATGTTGAATATCAAGGTTTTTGGTCAAGTTCATTAACTGATTCGGTAAGTCAAGGTAAGCCAGATATTGAGTTGCTT
GACATTAAGAACAGAATCTCAAATATAAGCGATATATTTGAGGTAACTTCCAAACCTCTAATTATAGATGGTGATACTGG
AGGGAAAATTGAACATTTATCATTCAACATAAGGTCTCTTGAGCGACTTGGCGTGTCAGCAATTATAATTGAAGATAAAA
CAGGGCTTAAGAAAAACTCATTATTAGGTAATGAGGTTGAACAGAAGCAAGATACAATAGAATCATTCTGCACAAAAATA
AAAAAAGGTAAAGAATCTCAATTAACAGAAGAATTTATGATTATTGCAAGGGTTGAAAGCTTAATTCTAGATGCTGGAAT
GGAGGATGCATTAGAAAGAGCTTTTGCTTATAGTGAAAGTGGTGCTGACGGAATAATGATCCACAGTCGACACCAAGATG
GAAAGGAAATATTTGATTTTGCGAAACAATATAGATCTAAGTATCCAGATAAGATATTAGTATGCGTACCTACTAGTTAC
AATGAAATAAAATTCGATGAACTTAAACAAGCTGGCTTCAATATTGTTATTTATGCAAATCACATGCTAAGAGCAGCATA
TAAGGCTATGGAATATACATCTGAGCAAATACTTAAAAATGGAAGAACATCTGAAATAGAATCTCACTTTCTATCAATAA
AAAGAATGCTAGATCTCGTGCCTGGAACTCGGTAA

Upstream 100 bases:

>100_bases
ATTATTACAATACTATAAAAGTGTGTTATTTATCACTGAAAATAAGTGTTAAGTGCGAAACTATTATTTAACAAATAATG
AAAGTAGAGATGAATAGTGA

Downstream 100 bases:

>100_bases
TGCTTATGTCTATATTTATATTAACATTAATGATTTTATCTCTAATATATAAGAGAAAATACATACCTTTGATTTTTATA
TTGTTAGGGATTGTTGTTTC

Product: phosphoenolpyruvate phosphomutase

Products: NA

Alternate protein names: PPH [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKNNDIKLSIPNIRRSRLINVIKSHGCIRILETHNPISALIAEKASANDIDSEENVEYQGFWSSSLTDSVSQGKPDIELL
DIKNRISNISDIFEVTSKPLIIDGDTGGKIEHLSFNIRSLERLGVSAIIIEDKTGLKKNSLLGNEVEQKQDTIESFCTKI
KKGKESQLTEEFMIIARVESLILDAGMEDALERAFAYSESGADGIMIHSRHQDGKEIFDFAKQYRSKYPDKILVCVPTSY
NEIKFDELKQAGFNIVIYANHMLRAAYKAMEYTSEQILKNGRTSEIESHFLSIKRMLDLVPGTR

Sequences:

>Translated_304_residues
MKNNDIKLSIPNIRRSRLINVIKSHGCIRILETHNPISALIAEKASANDIDSEENVEYQGFWSSSLTDSVSQGKPDIELL
DIKNRISNISDIFEVTSKPLIIDGDTGGKIEHLSFNIRSLERLGVSAIIIEDKTGLKKNSLLGNEVEQKQDTIESFCTKI
KKGKESQLTEEFMIIARVESLILDAGMEDALERAFAYSESGADGIMIHSRHQDGKEIFDFAKQYRSKYPDKILVCVPTSY
NEIKFDELKQAGFNIVIYANHMLRAAYKAMEYTSEQILKNGRTSEIESHFLSIKRMLDLVPGTR
>Mature_304_residues
MKNNDIKLSIPNIRRSRLINVIKSHGCIRILETHNPISALIAEKASANDIDSEENVEYQGFWSSSLTDSVSQGKPDIELL
DIKNRISNISDIFEVTSKPLIIDGDTGGKIEHLSFNIRSLERLGVSAIIIEDKTGLKKNSLLGNEVEQKQDTIESFCTKI
KKGKESQLTEEFMIIARVESLILDAGMEDALERAFAYSESGADGIMIHSRHQDGKEIFDFAKQYRSKYPDKILVCVPTSY
NEIKFDELKQAGFNIVIYANHMLRAAYKAMEYTSEQILKNGRTSEIESHFLSIKRMLDLVPGTR

Specific function: Hydrolyzes phosphonopyruvate. Not active towards phosphoenolpyruvate, glycerophosphate, phospho-L-serine or phosphoglycolic acid [H]

COG id: COG2513

COG function: function code G; PEP phosphonomutase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. PEP mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786525, Length=263, Percent_Identity=24.3346007604563, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000918
- InterPro:   IPR012649
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =3.11.1.3 [H]

Molecular weight: Translated: 34306; Mature: 34306

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNDIKLSIPNIRRSRLINVIKSHGCIRILETHNPISALIAEKASANDIDSEENVEYQG
CCCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEE
FWSSSLTDSVSQGKPDIELLDIKNRISNISDIFEVTSKPLIIDGDTGGKIEHLSFNIRSL
EECCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECHHHH
ERLGVSAIIIEDKTGLKKNSLLGNEVEQKQDTIESFCTKIKKGKESQLTEEFMIIARVES
HHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LILDAGMEDALERAFAYSESGADGIMIHSRHQDGKEIFDFAKQYRSKYPDKILVCVPTSY
HHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
NEIKFDELKQAGFNIVIYANHMLRAAYKAMEYTSEQILKNGRTSEIESHFLSIKRMLDLV
CCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PGTR
CCCC
>Mature Secondary Structure
MKNNDIKLSIPNIRRSRLINVIKSHGCIRILETHNPISALIAEKASANDIDSEENVEYQG
CCCCCEEEECCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCEEEE
FWSSSLTDSVSQGKPDIELLDIKNRISNISDIFEVTSKPLIIDGDTGGKIEHLSFNIRSL
EECCHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEEECHHHH
ERLGVSAIIIEDKTGLKKNSLLGNEVEQKQDTIESFCTKIKKGKESQLTEEFMIIARVES
HHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LILDAGMEDALERAFAYSESGADGIMIHSRHQDGKEIFDFAKQYRSKYPDKILVCVPTSY
HHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
NEIKFDELKQAGFNIVIYANHMLRAAYKAMEYTSEQILKNGRTSEIESHFLSIKRMLDLV
CCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
PGTR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12697754 [H]