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The map label for this gene is gyrA [H]

Identifier: 59711811

GI number: 59711811

Start: 1340000

End: 1342636

Strand: Direct

Name: gyrA [H]

Synonym: VF_1204

Alternate gene names: 59711811

Gene position: 1340000-1342636 (Clockwise)

Preceding gene: 172087692

Following gene: 59711813

Centisome position: 46.25

GC content: 42.06

Gene sequence:

>2637_bases
ATGAGCGATCTTGCTAAAGAGATCACGCCCGTAAATATTGAAGATGAGCTTCGAGGTTCTTACCTAGACTATGCGATGTC
AGTAATCGTTGGTCGTGCTCTTCCCGATGTGCGTGATGGCCTAAAACCAGTACACCGCCGCGTTTTATTCGCAATGGATG
TACTAGGTAATGATTGGAATAAACCATATAAAAAATCTGCCCGTGTTGTTGGCGACGTAATCGGTAAATATCACCCTCAC
GGTGATAGTGCTGTTTATGACACCATCGTACGTATGGCGCAGCCGTTCTCACTACGCTATATGCTTGTTGATGGCCAAGG
TAACTTCGGTTCTATCGATGGTGACTCAGCGGCGGCGATGCGTTATACCGAAGTTCGTATGGCGAAAATCGCTCACGAAT
TATTGGCTGATCTAGACAAAGAAACTGTAGATTATGTTCCTAACTATGATGGTACAGAACAGATCCCTGCAGTATTACCA
ACAAAGATCCCGAACCTACTTGTAAATGGTTCATCAGGTATCGCCGTTGGTATGGCAACAAACATCCCACCACACAACTT
AACAGAAGTGGTAAATGGTTGTTTGGCTTTCATCGAAAATGAAGAAATCACGATCGATGAGCTAATGAACTACATTCCAG
GTCCTGACTTCCCGACAGCTGCATTGATCAGTGGTCGTAAAGGCATCGTTGATGCTTATAAGACAGGTCGTGGTAAAGTT
TACATGCGTTCTAAAGCTAATATCGAAGCTGACAAGAATGGTAAAGAAACCATTATTGTTACAGAGATCCCTTATCAAGT
TAACAAAGCTCGCCTGATCGAAAAGATCGCTGAACTAGTTAAAGATAAGAAAGTAGAAGGCATTTCTGCACTACGTGACG
AATCTGATAAAGATGGTATGCGTATTGTTATTGAATGTAAGCGTGATGCAGTAGGTGAGGTTGTTCTTAATAACCTTTAC
TCTCTGACTCAACTTCAAACTACATTCGGTATCAACATGGTTGCACTAGATAATGGCCAACCAAAACTTTTCAACTTGAA
AGAAATGTTGAAGTGTTTCGTTGATCACCGTCGTGAAGTGGTAACTCGCCGTACTATTTTTGAATTACGCAAAGCGCGTG
ATCGTGCTCATATCCTTGAAGGTTTAGCACTAGCATTAGCGAACATCGATGAAATCATCGAATTGATCAAGAATGCACCA
ACACCAGCAGAAGCAAAAGAAGGTCTAATCTCACGTGGTTGGGATTTAGGTAACGTTGCTTCGATGCTAGAGCGTGCTGG
TACTGATGCTGCTCGTCCTGATTGGTTAGAGCCAGAGTTTGGTATTCGTGAAGGTAAATACTTCTTAACAGAACAACAAG
CTCAAGCAATCCTAGAACTTCGTCTACACCGTTTAACTGGTTTAGAGCACGAGAAGATCTTAGATGAATACAAAGCACTA
TTAGATGAAATCGCAGAGCTAATGCATATTCTTGCAAGCACTGAACGTCTGATGGAAGTGATCCGTGACGAATTAGTTAT
GGTTCGTGACATGTACGGTGATGAGCGTCGCACTGAAATCGGTGCTGCAATCCATGACATCGACATGGAAGACTTAATCA
CACAAGAAGATGTTGTAGTAACACTTTCTCGTGAAGGTTATGTTAAGTACCAAATTCTGAGCGATTACGAAGCACAACGT
CGTGGTGGTAAAGGTAAGAGTGCAACTAAGATGAAAGATGAAGATTTCATCGAACGTCTACTTGTTGCGAATACTCATGA
TAATATCCTTTGTTTCTCTACACGTGGTAAAGCGTATAGCTTGAAAGTATTCCAATTACCTCAAGCAAGTCGTACTGCTC
GTGGTAAGCCAATCGTAAACATTCTTCCTCTAGAAGAAGGTGAGCGTATTACAGCGATTCTACCAGTATCTGAATATTCT
GAAGATAAGTTTATCTTTATGGCAACAGGTGATGGTACTGTTAAGAAAACATCACTAGATCAATTTGCAAAAGTTCGTGC
AAACGGCTTAATCGCAGTAAATCTACGTGAAGATGATTCACTAATCGGTGTTGATATCACTGATGGTTCAAGTGAAATCA
TGCTGTTCTCTAAAGCTGGTAAAGTGGTTCGTTTCAACGAAGAACAAGTTCGTGGTATGGGCCGTACAGCTTCTGGTGTT
CGTGGTATGAAACTGTCTGGTGAAGATCAGGTTGTTTCGTTAATCGTTCCTTCTAATGAAGGCGATATCTTAACAGTGAC
TCAAAATGGTTACGGTAAACGTACTGTTCTTTCTGAGTATCCTGCGAAGAGCCGTGCAACGCAAGGTGTTGTATCTATCA
AAGTTTCTGAACGTAACGGCAGTGTTGTTGGTGCAGTTCAAGCTGAAGATGGCGATGAATTCATGATGATCACTGACGCA
GGTACGCTAGTACGTACTCGTGTATCAGAAGTTAGCCAAGTGGGTCGTAATACTCAAGGTGTAACATTGATCCGTACTTC
TGAAAATGAAAATGTAGTTGCACTGCAACGCATTGATGAAGTTGAAGAAGCAGAAATCATTGAAGGTGAAGAGGGTGAAG
TAACAGAGGCAACAGTAACAACTGAAGCGACTGATGCACCTCAAGCTGATACTGACGCTGAGAGCACAGAAGAATAA

Upstream 100 bases:

>100_bases
CACGTTTATCAGTATTAATTATCTTGGTGCATAGAAGTAGTATTATTTGCTAAGGCAATTGATATTGATACGACAGAACT
AATTGAGGGATATTGGCTCT

Downstream 100 bases:

>100_bases
TTTATTCTGATGTTTTCAAATAAAAAGCCCGCTTAGAAATAAGCGGGCTTTTTTTATCATTAAAAAACGTCGAAAATGCC
TTGTTCTGAATATAAGTTTG

Product: DNA gyrase (type II topoisomerase), subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 878; Mature: 877

Protein sequence:

>878_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEEITIDELMNYIPGPDFPTAALISGRKGIVDAYKTGRGKV
YMRSKANIEADKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
SLTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIIELIKNAP
TPAEAKEGLISRGWDLGNVASMLERAGTDAARPDWLEPEFGIREGKYFLTEQQAQAILELRLHRLTGLEHEKILDEYKAL
LDEIAELMHILASTERLMEVIRDELVMVRDMYGDERRTEIGAAIHDIDMEDLITQEDVVVTLSREGYVKYQILSDYEAQR
RGGKGKSATKMKDEDFIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYS
EDKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITDGSSEIMLFSKAGKVVRFNEEQVRGMGRTASGV
RGMKLSGEDQVVSLIVPSNEGDILTVTQNGYGKRTVLSEYPAKSRATQGVVSIKVSERNGSVVGAVQAEDGDEFMMITDA
GTLVRTRVSEVSQVGRNTQGVTLIRTSENENVVALQRIDEVEEAEIIEGEEGEVTEATVTTEATDAPQADTDAESTEE

Sequences:

>Translated_878_residues
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVIGKYHPH
GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLP
TKIPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEEITIDELMNYIPGPDFPTAALISGRKGIVDAYKTGRGKV
YMRSKANIEADKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLY
SLTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIIELIKNAP
TPAEAKEGLISRGWDLGNVASMLERAGTDAARPDWLEPEFGIREGKYFLTEQQAQAILELRLHRLTGLEHEKILDEYKAL
LDEIAELMHILASTERLMEVIRDELVMVRDMYGDERRTEIGAAIHDIDMEDLITQEDVVVTLSREGYVKYQILSDYEAQR
RGGKGKSATKMKDEDFIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYS
EDKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITDGSSEIMLFSKAGKVVRFNEEQVRGMGRTASGV
RGMKLSGEDQVVSLIVPSNEGDILTVTQNGYGKRTVLSEYPAKSRATQGVVSIKVSERNGSVVGAVQAEDGDEFMMITDA
GTLVRTRVSEVSQVGRNTQGVTLIRTSENENVVALQRIDEVEEAEIIEGEEGEVTEATVTTEATDAPQADTDAESTEE
>Mature_877_residues
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWNKPYKKSARVVGDVIGKYHPHG
DSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPT
KIPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAFIENEEITIDELMNYIPGPDFPTAALISGRKGIVDAYKTGRGKVY
MRSKANIEADKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGMRIVIECKRDAVGEVVLNNLYS
LTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREVVTRRTIFELRKARDRAHILEGLALALANIDEIIELIKNAPT
PAEAKEGLISRGWDLGNVASMLERAGTDAARPDWLEPEFGIREGKYFLTEQQAQAILELRLHRLTGLEHEKILDEYKALL
DEIAELMHILASTERLMEVIRDELVMVRDMYGDERRTEIGAAIHDIDMEDLITQEDVVVTLSREGYVKYQILSDYEAQRR
GGKGKSATKMKDEDFIERLLVANTHDNILCFSTRGKAYSLKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYSE
DKFIFMATGDGTVKKTSLDQFAKVRANGLIAVNLREDDSLIGVDITDGSSEIMLFSKAGKVVRFNEEQVRGMGRTASGVR
GMKLSGEDQVVSLIVPSNEGDILTVTQNGYGKRTVLSEYPAKSRATQGVVSIKVSERNGSVVGAVQAEDGDEFMMITDAG
TLVRTRVSEVSQVGRNTQGVTLIRTSENENVVALQRIDEVEEAEIIEGEEGEVTEATVTTEATDAPQADTDAESTEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=347, Percent_Identity=27.6657060518732, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI19913406, Length=419, Percent_Identity=26.2529832935561, Blast_Score=84, Evalue=7e-16,
Organism=Escherichia coli, GI1788562, Length=879, Percent_Identity=74.6302616609784, Blast_Score=1353, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=718, Percent_Identity=37.6044568245125, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI212645845, Length=372, Percent_Identity=25.5376344086022, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=286, Percent_Identity=27.972027972028, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=282, Percent_Identity=28.0141843971631, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.2247838616715, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136538, Length=401, Percent_Identity=27.6807980049875, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 97165; Mature: 97034

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWN
CCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVVNGCLAFIENEEITIDELMNYIPGPDFPTAALISGRKGIVDAYKTGRGKV
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHCCCCEE
YMRSKANIEADKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYSLTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELRKARDRAHILEGLALALANIDEIIELIKNAPTPAEAKEGLISRGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH
SMLERAGTDAARPDWLEPEFGIREGKYFLTEQQAQAILELRLHRLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEIAELMHILASTERLMEVIRDELVMVRDMYGDERRTEIGAAIHDIDMEDLITQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCEEE
TLSREGYVKYQILSDYEAQRRGGKGKSATKMKDEDFIERLLVANTHDNILCFSTRGKAYS
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEE
LKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYSEDKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCEEECCHH
QFAKVRANGLIAVNLREDDSLIGVDITDGSSEIMLFSKAGKVVRFNEEQVRGMGRTASGV
HHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEECHHHHHCCCCCCCCC
RGMKLSGEDQVVSLIVPSNEGDILTVTQNGYGKRTVLSEYPAKSRATQGVVSIKVSERNG
CCCEECCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHCCCCHHCCCCEEEEEEECCCC
SVVGAVQAEDGDEFMMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTSENENVVALQRIDE
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEHHCC
VEEAEIIEGEEGEVTEATVTTEATDAPQADTDAESTEE
CHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAKEITPVNIEDELRGSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMDVLGNDWN
CCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLDKETVDYVPNYDGTEQIPAVLPTKIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
NIPPHNLTEVVNGCLAFIENEEITIDELMNYIPGPDFPTAALISGRKGIVDAYKTGRGKV
CCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHCCCCEE
YMRSKANIEADKNGKETIIVTEIPYQVNKARLIEKIAELVKDKKVEGISALRDESDKDGM
EEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCC
RIVIECKRDAVGEVVLNNLYSLTQLQTTFGINMVALDNGQPKLFNLKEMLKCFVDHRREV
EEEEEECCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCEECHHHHHHHHHHHHHHH
VTRRTIFELRKARDRAHILEGLALALANIDEIIELIKNAPTPAEAKEGLISRGWDLGNVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHH
SMLERAGTDAARPDWLEPEFGIREGKYFLTEQQAQAILELRLHRLTGLEHEKILDEYKAL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEIAELMHILASTERLMEVIRDELVMVRDMYGDERRTEIGAAIHDIDMEDLITQEDVVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHCCCCCEEE
TLSREGYVKYQILSDYEAQRRGGKGKSATKMKDEDFIERLLVANTHDNILCFSTRGKAYS
EEECCCEEEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEE
LKVFQLPQASRTARGKPIVNILPLEEGERITAILPVSEYSEDKFIFMATGDGTVKKTSLD
EEEEECCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCCEEECCHH
QFAKVRANGLIAVNLREDDSLIGVDITDGSSEIMLFSKAGKVVRFNEEQVRGMGRTASGV
HHHHHHCCCEEEEEECCCCCEEEEEECCCCCCEEEEECCCCEEEECHHHHHCCCCCCCCC
RGMKLSGEDQVVSLIVPSNEGDILTVTQNGYGKRTVLSEYPAKSRATQGVVSIKVSERNG
CCCEECCCCCEEEEEEECCCCCEEEEECCCCCCCCHHHHCCCCHHCCCCEEEEEEECCCC
SVVGAVQAEDGDEFMMITDAGTLVRTRVSEVSQVGRNTQGVTLIRTSENENVVALQRIDE
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEHHCC
VEEAEIIEGEEGEVTEATVTTEATDAPQADTDAESTEE
CHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 8849216 [H]