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The map label for this gene is macB [H]

Identifier: 59711771

GI number: 59711771

Start: 1291282

End: 1292565

Strand: Direct

Name: macB [H]

Synonym: VF_1164

Alternate gene names: 59711771

Gene position: 1291282-1292565 (Clockwise)

Preceding gene: 59711770

Following gene: 59711772

Centisome position: 44.56

GC content: 37.38

Gene sequence:

>1284_bases
ATGCTATTGCCAATGAGACTAATATTTCAAGAAATGGCTGCTGAGAAAGTACGCTTGAGTTTACTTCTCTTAGCTGTGGC
ATGGGCGACATTATGTATTGCAACTATGCTTGCAGTTGGTGAAGGCTTACGTCAGGGAGTGATCCGAAGTTCAGAGAGCG
GTAATGGTAAATTAATCTACCTTACTGGAGGTTATGCCACTATAAATTCAAGTAACTTCTACATTGGTAAAGCATTGCAG
CTGACATCGGAAGATCTAAAAGTAATAAAAGTCTTACCAAGTGTAAAGCATGCTCAACTAAGTGCTATTTGGGATGAACA
AGCAAATTATAAAGATCATAGAACTTGGCAAAAACCACTTGCCGTATATCCTGATTATCAAGCATTAACTGGCTTAAAAA
TAGTACCAGGAGGGCGATGGTTTAATCTTTTAGATATCAAAGAACAGCGTAAAGTGATTATATTAGGTGAAAGTGCCGCT
ATCTCTTTATTCAATGAATCGAATGACTTTGATTGGATGAATCCCCCTAAATTAAAGGTTGATCCGGTTGGTAAAAAAAT
AAAATTGGGTAGTGAAGAGTTTATTGTTATTGGTTTGATTAAGCGTAGTAGTGCAAATATAGAACAAGGTATACCGCTTA
ATGAATCACTTTTTATACCGTTTACAACTTGGAAGCGCTTTCATCAAAATAGTGCTATATCTGCAATTAATATAGAGCTA
ATGGCTAATGCAGATCGCAAGCAAGTAGCTAAAACCGTTAAACAAGTGATTGCTAGAAAGTATGGAGCAAGCATTGAAGA
TGATAAATTGCTTCAAGTTGAAGATATGCTATTAAAACAGAAAACCATACGACAATTTTTAATTGGTTTACAAGGTTTCC
TTGGCATTATTGGTTTAGTGACTGTGGGCGTTGCAGGGATTGGAATTGCAAATGTAATGTACGCGACAGTTAAGCGTTCG
ACTAAAGATATAGGTGTCAGAATGGCAATTGGAGCAACCCCCATAACCATACGTCTGCACTATTTAACGCAATCATTGTT
TACGATGAGCGTTGGCGGGGGGATGGGGTTAGGTTTAACTTATTTTTTAATGCTATTAATACAAGCGCTCCCTTTAGCTG
GAAATGATTTGTATGATGAGTTAGGACAGCCAACACCAGAACTCTCTTTACCTATTGTTGGTTTAATTATATTAGCATTA
GGACTTGTTGGTATTTTAGCAGCTTGGTTCCCTGCGAATAGAGCTGCATTAATAACCCCATTAGAGGCATTACAGAGTGA
ATAA

Upstream 100 bases:

>100_bases
AGGGGTGACAGCTGTATTGGCATTATTAGCAGCGTATTTTCCTGCGCGTCGTGCATCGAATTTACTTCCAGTCATTGCCT
TAAGTGCGAGGGCTTGATTA

Downstream 100 bases:

>100_bases
CCATCATAAGCAAAGGGGGGGGACCTCCTTAATAAAAGATTTAGTCACACTTCGTGATATTAGCAAGCATTACAAAAATG
GTACCGAAGAAGTTCGTGCT

Product: export ABC transporter permease protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLLPMRLIFQEMAAEKVRLSLLLLAVAWATLCIATMLAVGEGLRQGVIRSSESGNGKLIYLTGGYATINSSNFYIGKALQ
LTSEDLKVIKVLPSVKHAQLSAIWDEQANYKDHRTWQKPLAVYPDYQALTGLKIVPGGRWFNLLDIKEQRKVIILGESAA
ISLFNESNDFDWMNPPKLKVDPVGKKIKLGSEEFIVIGLIKRSSANIEQGIPLNESLFIPFTTWKRFHQNSAISAINIEL
MANADRKQVAKTVKQVIARKYGASIEDDKLLQVEDMLLKQKTIRQFLIGLQGFLGIIGLVTVGVAGIGIANVMYATVKRS
TKDIGVRMAIGATPITIRLHYLTQSLFTMSVGGGMGLGLTYFLMLLIQALPLAGNDLYDELGQPTPELSLPIVGLIILAL
GLVGILAAWFPANRAALITPLEALQSE

Sequences:

>Translated_427_residues
MLLPMRLIFQEMAAEKVRLSLLLLAVAWATLCIATMLAVGEGLRQGVIRSSESGNGKLIYLTGGYATINSSNFYIGKALQ
LTSEDLKVIKVLPSVKHAQLSAIWDEQANYKDHRTWQKPLAVYPDYQALTGLKIVPGGRWFNLLDIKEQRKVIILGESAA
ISLFNESNDFDWMNPPKLKVDPVGKKIKLGSEEFIVIGLIKRSSANIEQGIPLNESLFIPFTTWKRFHQNSAISAINIEL
MANADRKQVAKTVKQVIARKYGASIEDDKLLQVEDMLLKQKTIRQFLIGLQGFLGIIGLVTVGVAGIGIANVMYATVKRS
TKDIGVRMAIGATPITIRLHYLTQSLFTMSVGGGMGLGLTYFLMLLIQALPLAGNDLYDELGQPTPELSLPIVGLIILAL
GLVGILAAWFPANRAALITPLEALQSE
>Mature_427_residues
MLLPMRLIFQEMAAEKVRLSLLLLAVAWATLCIATMLAVGEGLRQGVIRSSESGNGKLIYLTGGYATINSSNFYIGKALQ
LTSEDLKVIKVLPSVKHAQLSAIWDEQANYKDHRTWQKPLAVYPDYQALTGLKIVPGGRWFNLLDIKEQRKVIILGESAA
ISLFNESNDFDWMNPPKLKVDPVGKKIKLGSEEFIVIGLIKRSSANIEQGIPLNESLFIPFTTWKRFHQNSAISAINIEL
MANADRKQVAKTVKQVIARKYGASIEDDKLLQVEDMLLKQKTIRQFLIGLQGFLGIIGLVTVGVAGIGIANVMYATVKRS
TKDIGVRMAIGATPITIRLHYLTQSLFTMSVGGGMGLGLTYFLMLLIQALPLAGNDLYDELGQPTPELSLPIVGLIILAL
GLVGILAAWFPANRAALITPLEALQSE

Specific function: Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation [H]

COG id: COG0577

COG function: function code V; ABC-type antimicrobial peptide transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1787105, Length=428, Percent_Identity=23.3644859813084, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR017911
- InterPro:   IPR003593
- InterPro:   IPR003838 [H]

Pfam domain/function: PF00005 ABC_tran; PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 46799; Mature: 46799

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPMRLIFQEMAAEKVRLSLLLLAVAWATLCIATMLAVGEGLRQGVIRSSESGNGKLIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LTGGYATINSSNFYIGKALQLTSEDLKVIKVLPSVKHAQLSAIWDEQANYKDHRTWQKPL
EECCEEEECCCCEEEEEEEEECHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCC
AVYPDYQALTGLKIVPGGRWFNLLDIKEQRKVIILGESAAISLFNESNDFDWMNPPKLKV
CCCCCHHHHCCCEEECCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCCCCCCCCEEE
DPVGKKIKLGSEEFIVIGLIKRSSANIEQGIPLNESLFIPFTTWKRFHQNSAISAINIEL
CCCCCEEECCCCCEEEEEEEECCCCCHHCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEEE
MANADRKQVAKTVKQVIARKYGASIEDDKLLQVEDMLLKQKTIRQFLIGLQGFLGIIGLV
EECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVGVAGIGIANVMYATVKRSTKDIGVRMAIGATPITIRLHYLTQSLFTMSVGGGMGLGLT
HHHHHHHHHHHHHHHHHHHCHHHCCEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCHHHH
YFLMLLIQALPLAGNDLYDELGQPTPELSLPIVGLIILALGLVGILAAWFPANRAALITP
HHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
LEALQSE
HHHHCCC
>Mature Secondary Structure
MLLPMRLIFQEMAAEKVRLSLLLLAVAWATLCIATMLAVGEGLRQGVIRSSESGNGKLIY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LTGGYATINSSNFYIGKALQLTSEDLKVIKVLPSVKHAQLSAIWDEQANYKDHRTWQKPL
EECCEEEECCCCEEEEEEEEECHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHCCC
AVYPDYQALTGLKIVPGGRWFNLLDIKEQRKVIILGESAAISLFNESNDFDWMNPPKLKV
CCCCCHHHHCCCEEECCCCEEEEEECCCCCEEEEEECCEEEEEECCCCCCCCCCCCCEEE
DPVGKKIKLGSEEFIVIGLIKRSSANIEQGIPLNESLFIPFTTWKRFHQNSAISAINIEL
CCCCCEEECCCCCEEEEEEEECCCCCHHCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEEE
MANADRKQVAKTVKQVIARKYGASIEDDKLLQVEDMLLKQKTIRQFLIGLQGFLGIIGLV
EECCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVGVAGIGIANVMYATVKRSTKDIGVRMAIGATPITIRLHYLTQSLFTMSVGGGMGLGLT
HHHHHHHHHHHHHHHHHHHCHHHCCEEEEECCCEEEEEEHHHHHHHHHHCCCCCCCHHHH
YFLMLLIQALPLAGNDLYDELGQPTPELSLPIVGLIILALGLVGILAAWFPANRAALITP
HHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
LEALQSE
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA