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The map label for this gene is murP

Identifier: 59711722

GI number: 59711722

Start: 1227806

End: 1229260

Strand: Direct

Name: murP

Synonym: VF_1115

Alternate gene names: 59711722

Gene position: 1227806-1229260 (Clockwise)

Preceding gene: 59711721

Following gene: 172087691

Centisome position: 42.37

GC content: 41.17

Gene sequence:

>1455_bases
ATGGCTAAAATAACCACTTCCATGATTCAAGAGATACTGACCGCAATTGGTGGCAAATCAAATGTCATTAAGTGTGGAAA
CTGTATGACACGTCTGCGCCTTACCCTTCATGATGATAATTTAGCAGATAGAGACACTATCAAACGTATTGCAGGTGTGA
TGGGACTTGTTGAGAGTGATGATCAATTTCAAATCGTATTAGGTCCGGGTAAAGCACAAACGGCAGCTGAGATGATGAAT
GAAATGATGGAAGGAGAGGAAGATAACTCAGCTTCAACAACGGCCGAAAGCCGAGATTTAAAAGACGTTGCATCAGAACA
TAAACAGAAGTTAAAGAAAAAACAAACCAGCGCAGCACAACGTTTTTTGAGCAAGTTTGCTACCATTTTTACTCCATTAA
TTCCGGGGTTCATTGCTGCTGGTCTGTTACTTGGTTTCGCAACCTTACTTGATCAAATTTATATCATAGGTAATGAGTCA
CCAAATGCGAATCTGGTGGATTTAATTCTTTATATGAAAGTCTTTAGTAAAGGCTTATTCAGCTTCTTAAGTATTTTAAT
TGGCTACAATGCACAACAAGCATTTGGTGGTTCAGGTGTAAATGGTGCGATCCTAGCGTCATTGTTTGTACTTGGTTATA
ACCCTGATGCAACCTCTGGTATTTATTCTGGTATGACGGACTTCTTTGGTCATGGTATTGACCCAAGAGGTAACATTATT
GGTGTATTGATTGCCGCTATTATAGGTGCTGGCGTTGAGAAGAAAGTTCGCCAATACATGCCTGATAACCTAGATATGAT
TTTAACTTCGGTTGTGACGTTACTTATTATGGGTGCGGTTACCTTTGTGGTTATCATGCCGATAGGTGGTGTGTTATTCC
AAGGTATGTCATGGTTATTCATGAACTTAAACGGCAACCCAATTGGTAGTGCAATTCTTGCGGGTCTGTTTTTAATCTCA
GTAATGTTTGGTATTCACCAAGGCTTTGTACCGGTTTACTTTGCTCTAATGGATGCACAAGGCTTTAACTCACTGTTCCC
AATCCTTGCGATGGCAGGTGCAGGTCAAGTGGGGGCGGCATTGGCTCTGTATGCAAAAGCAAATAAAGACGCGTTGTTAC
GTACTCAAGTAAAAGGTTCTATTATCCCAGGCTTTTTAGGCATAGGTGAGCCACTTATTTACGGTGTAACACTTCCACGA
GTGAAACCATTTATCACAGCTTGTGTAGGTGGTGCTGCAGGTGGCTTCTTTATCGGCTTAGTTTCATACATGGGCTTACC
AGTAGGTTTGAATACTGTATTTGGTCCATCAGGTATCGTTGCTCTACCTCTTATGACATCTAACGCAGGTATCTTTGCCG
GAATGCTAGTCTTTGCAGCAGGTTTGGTCATCTCATATGTCGCTGGCTTTCTTGCAACTTGGTTCTTCGGAACAAAGAAT
GTTGATTTAAGCTAA

Upstream 100 bases:

>100_bases
TTTCAGACCAGTAATTGGTAACAAGGCCTTATACCAATCTGGATGAATCAAATTTTATCTAGGTTGGTACCTCAACGAAC
AAATTAAAAAGGAACAGAAG

Downstream 100 bases:

>100_bases
GAGAAGAGTTCATAGAATAAATTAACGAATAAAAAGTACTTTCCCCTATAAGTACGCTAAGGCCTCACAGGTACCACTGT
GGGGCCTTTTTTCTTGATTT

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MAKITTSMIQEILTAIGGKSNVIKCGNCMTRLRLTLHDDNLADRDTIKRIAGVMGLVESDDQFQIVLGPGKAQTAAEMMN
EMMEGEEDNSASTTAESRDLKDVASEHKQKLKKKQTSAAQRFLSKFATIFTPLIPGFIAAGLLLGFATLLDQIYIIGNES
PNANLVDLILYMKVFSKGLFSFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPDATSGIYSGMTDFFGHGIDPRGNII
GVLIAAIIGAGVEKKVRQYMPDNLDMILTSVVTLLIMGAVTFVVIMPIGGVLFQGMSWLFMNLNGNPIGSAILAGLFLIS
VMFGIHQGFVPVYFALMDAQGFNSLFPILAMAGAGQVGAALALYAKANKDALLRTQVKGSIIPGFLGIGEPLIYGVTLPR
VKPFITACVGGAAGGFFIGLVSYMGLPVGLNTVFGPSGIVALPLMTSNAGIFAGMLVFAAGLVISYVAGFLATWFFGTKN
VDLS

Sequences:

>Translated_484_residues
MAKITTSMIQEILTAIGGKSNVIKCGNCMTRLRLTLHDDNLADRDTIKRIAGVMGLVESDDQFQIVLGPGKAQTAAEMMN
EMMEGEEDNSASTTAESRDLKDVASEHKQKLKKKQTSAAQRFLSKFATIFTPLIPGFIAAGLLLGFATLLDQIYIIGNES
PNANLVDLILYMKVFSKGLFSFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPDATSGIYSGMTDFFGHGIDPRGNII
GVLIAAIIGAGVEKKVRQYMPDNLDMILTSVVTLLIMGAVTFVVIMPIGGVLFQGMSWLFMNLNGNPIGSAILAGLFLIS
VMFGIHQGFVPVYFALMDAQGFNSLFPILAMAGAGQVGAALALYAKANKDALLRTQVKGSIIPGFLGIGEPLIYGVTLPR
VKPFITACVGGAAGGFFIGLVSYMGLPVGLNTVFGPSGIVALPLMTSNAGIFAGMLVFAAGLVISYVAGFLATWFFGTKN
VDLS
>Mature_483_residues
AKITTSMIQEILTAIGGKSNVIKCGNCMTRLRLTLHDDNLADRDTIKRIAGVMGLVESDDQFQIVLGPGKAQTAAEMMNE
MMEGEEDNSASTTAESRDLKDVASEHKQKLKKKQTSAAQRFLSKFATIFTPLIPGFIAAGLLLGFATLLDQIYIIGNESP
NANLVDLILYMKVFSKGLFSFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPDATSGIYSGMTDFFGHGIDPRGNIIG
VLIAAIIGAGVEKKVRQYMPDNLDMILTSVVTLLIMGAVTFVVIMPIGGVLFQGMSWLFMNLNGNPIGSAILAGLFLISV
MFGIHQGFVPVYFALMDAQGFNSLFPILAMAGAGQVGAALALYAKANKDALLRTQVKGSIIPGFLGIGEPLIYGVTLPRV
KPFITACVGGAAGGFFIGLVSYMGLPVGLNTVFGPSGIVALPLMTSNAGIFAGMLVFAAGLVISYVAGFLATWFFGTKNV
DLS

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1263

COG function: function code G; Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain

Homologues:

Organism=Escherichia coli, GI1788769, Length=485, Percent_Identity=61.4432989690722, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI1790159, Length=442, Percent_Identity=27.3755656108597, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI2367362, Length=434, Percent_Identity=23.2718894009217, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI48994906, Length=428, Percent_Identity=24.0654205607477, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTYBC_VIBF1 (Q5E5T6)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204498.1
- ProteinModelPortal:   Q5E5T6
- SMR:   Q5E5T6
- STRING:   Q5E5T6
- GeneID:   3278403
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1115
- NMPDR:   fig|312309.3.peg.962
- eggNOG:   COG1263
- HOGENOM:   HBG673521
- OMA:   RTQIKGA
- PhylomeDB:   Q5E5T6
- ProtClustDB:   PRK09586
- BioCyc:   VFIS312309:VF1115-MONOMER
- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013
- Gene3D:   G3DSA:3.30.1360.60

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC; SSF55604 PTS_EIIB

EC number: =2.7.1.69

Molecular weight: Translated: 51099; Mature: 50968

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS51098 PTS_EIIB_TYPE_1; PS01035 PTS_EIIB_TYPE_1_CYS; PS51103 PTS_EIIC_TYPE_1

Important sites: ACT_SITE 28-28

Signals:

None

Transmembrane regions:

HASH(0xef18a2c)-; HASH(0x10da818c)-; HASH(0xfb9cd1c)-; HASH(0x10d8fdcc)-; HASH(0x10cfc0f4)-; HASH(0x1006bfb0)-; HASH(0x10d0e870)-; HASH(0x10931a3c)-; HASH(0xfce22c0)-; HASH(0x10571680)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKITTSMIQEILTAIGGKSNVIKCGNCMTRLRLTLHDDNLADRDTIKRIAGVMGLVESD
CCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCC
DQFQIVLGPGKAQTAAEMMNEMMEGEEDNSASTTAESRDLKDVASEHKQKLKKKQTSAAQ
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSKFATIFTPLIPGFIAAGLLLGFATLLDQIYIIGNESPNANLVDLILYMKVFSKGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHH
SFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPDATSGIYSGMTDFFGHGIDPRGNII
HHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
GVLIAAIIGAGVEKKVRQYMPDNLDMILTSVVTLLIMGAVTFVVIMPIGGVLFQGMSWLF
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
MNLNGNPIGSAILAGLFLISVMFGIHQGFVPVYFALMDAQGFNSLFPILAMAGAGQVGAA
EECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
LALYAKANKDALLRTQVKGSIIPGFLGIGEPLIYGVTLPRVKPFITACVGGAAGGFFIGL
HHHHHHCCCCHHHHHHHCCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
VSYMGLPVGLNTVFGPSGIVALPLMTSNAGIFAGMLVFAAGLVISYVAGFLATWFFGTKN
HHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDLS
CCCH
>Mature Secondary Structure 
AKITTSMIQEILTAIGGKSNVIKCGNCMTRLRLTLHDDNLADRDTIKRIAGVMGLVESD
CCHHHHHHHHHHHHHCCCCCEEECCCHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCC
DQFQIVLGPGKAQTAAEMMNEMMEGEEDNSASTTAESRDLKDVASEHKQKLKKKQTSAAQ
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSKFATIFTPLIPGFIAAGLLLGFATLLDQIYIIGNESPNANLVDLILYMKVFSKGLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHH
SFLSILIGYNAQQAFGGSGVNGAILASLFVLGYNPDATSGIYSGMTDFFGHGIDPRGNII
HHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHH
GVLIAAIIGAGVEKKVRQYMPDNLDMILTSVVTLLIMGAVTFVVIMPIGGVLFQGMSWLF
HHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
MNLNGNPIGSAILAGLFLISVMFGIHQGFVPVYFALMDAQGFNSLFPILAMAGAGQVGAA
EECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
LALYAKANKDALLRTQVKGSIIPGFLGIGEPLIYGVTLPRVKPFITACVGGAAGGFFIGL
HHHHHHCCCCHHHHHHHCCCCCCHHHCCCCHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
VSYMGLPVGLNTVFGPSGIVALPLMTSNAGIFAGMLVFAAGLVISYVAGFLATWFFGTKN
HHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDLS
CCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA