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The map label for this gene is ttdR [H]

Identifier: 59711702

GI number: 59711702

Start: 1209479

End: 1210414

Strand: Direct

Name: ttdR [H]

Synonym: VF_1095

Alternate gene names: 59711702

Gene position: 1209479-1210414 (Clockwise)

Preceding gene: 59711701

Following gene: 59711703

Centisome position: 41.74

GC content: 39.1

Gene sequence:

>936_bases
ATGCATGACCGAGCGAGTCAAATGGTGATATTTTACGCCTTAGCGAAAGCTGGGAGTTTTACTGCTGCAGCAAAGCAAAT
GGGCGTATCAACCTCACATGTCAGTAAGCAGCTTGGTGCTTTAGAAGAAACGCTTAATCTAAAATTGGTGCATAGAACAA
CACGCTCTCTTATTTTAACGGATGCGGGACAACAGTTTTTTCTGTATTGCGAGACCATTTATAATGCAATGACAGAAGCA
AGTGCCATTATGGATGATGAACGAGATGAAGTCGCAGGTATTCTACGTTTAGGTTTATCCCAATCTTTTGGCACTATGCA
TATCATTCCGGCTATTGATAAGTTGCGAAACCAATACCCTGATTTACAAGTTGAAGTTCGCTTATTTGATCATCAAGCTG
ACATGTTAAAAGATGGTTTAGATTTATGGGTAACTAATTTTGAAGACTTGCCTGAAGGTTATGTTGCACAGCGTTTAGCT
GATTCTAATTTTGTTTTAGCGGCATCTCCTGATTACCTTATTGATAAAAAAGTTCCGCATCATCCTTTGGATCTTGTTGA
ACATAATTGTCTTACTTACCAGAGTCGCTATCGTGATTACAGTAATTGGGATTTTAGTAAGGGTAATGAATCTCTATGCG
TAAAGGTATCTGGTAATTATCGAGTTGATTTAGCTGAGGCTGTTAGAGATGCAACCATATCAGGGTGGGGCATTGCTTAT
TTAGCCAGTTATTTGCTAACTAATGAGTTTAATGATGGAAAACTCATTCAATTATTACCGGGTTGGAAAGCAAGTCAGAA
AATGCCGATTTATGCGGTATATCCAAGTCGAAAACACCTTCCAAGAAAGATAAGTGCGGTCATCGATTTTCTTCGAGAAC
ATATAGGCCAACCGCCATATTGGGATAAAGCACTCATGAAGCGAGTGAAGTTGTAA

Upstream 100 bases:

>100_bases
CCTAATTTCATTTTTATAAAATGCCAAAAGCTAGTTTAGTCTTACCATCTAGTGTTACTATCTGCGCCCCAATTTTCCTT
TGAGTTTGAGGAGCAGATAG

Downstream 100 bases:

>100_bases
CGTTTGCTATTCCTCATTGATTGAATTTCATACTTTAAATTGTTGTCTTTTTAATCAATGAGTTATATCGATTATGTGCC
GTGAAATAAATATCTTTTCC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MHDRASQMVIFYALAKAGSFTAAAKQMGVSTSHVSKQLGALEETLNLKLVHRTTRSLILTDAGQQFFLYCETIYNAMTEA
SAIMDDERDEVAGILRLGLSQSFGTMHIIPAIDKLRNQYPDLQVEVRLFDHQADMLKDGLDLWVTNFEDLPEGYVAQRLA
DSNFVLAASPDYLIDKKVPHHPLDLVEHNCLTYQSRYRDYSNWDFSKGNESLCVKVSGNYRVDLAEAVRDATISGWGIAY
LASYLLTNEFNDGKLIQLLPGWKASQKMPIYAVYPSRKHLPRKISAVIDFLREHIGQPPYWDKALMKRVKL

Sequences:

>Translated_311_residues
MHDRASQMVIFYALAKAGSFTAAAKQMGVSTSHVSKQLGALEETLNLKLVHRTTRSLILTDAGQQFFLYCETIYNAMTEA
SAIMDDERDEVAGILRLGLSQSFGTMHIIPAIDKLRNQYPDLQVEVRLFDHQADMLKDGLDLWVTNFEDLPEGYVAQRLA
DSNFVLAASPDYLIDKKVPHHPLDLVEHNCLTYQSRYRDYSNWDFSKGNESLCVKVSGNYRVDLAEAVRDATISGWGIAY
LASYLLTNEFNDGKLIQLLPGWKASQKMPIYAVYPSRKHLPRKISAVIDFLREHIGQPPYWDKALMKRVKL
>Mature_311_residues
MHDRASQMVIFYALAKAGSFTAAAKQMGVSTSHVSKQLGALEETLNLKLVHRTTRSLILTDAGQQFFLYCETIYNAMTEA
SAIMDDERDEVAGILRLGLSQSFGTMHIIPAIDKLRNQYPDLQVEVRLFDHQADMLKDGLDLWVTNFEDLPEGYVAQRLA
DSNFVLAASPDYLIDKKVPHHPLDLVEHNCLTYQSRYRDYSNWDFSKGNESLCVKVSGNYRVDLAEAVRDATISGWGIAY
LASYLLTNEFNDGKLIQLLPGWKASQKMPIYAVYPSRKHLPRKISAVIDFLREHIGQPPYWDKALMKRVKL

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=301, Percent_Identity=31.2292358803987, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87081978, Length=288, Percent_Identity=29.1666666666667, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786401, Length=299, Percent_Identity=27.7591973244147, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789639, Length=292, Percent_Identity=29.1095890410959, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787128, Length=294, Percent_Identity=26.530612244898, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=26.8041237113402, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787589, Length=290, Percent_Identity=24.8275862068966, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789173, Length=247, Percent_Identity=29.5546558704453, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788706, Length=294, Percent_Identity=22.4489795918367, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786448, Length=277, Percent_Identity=24.187725631769, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790011, Length=299, Percent_Identity=22.742474916388, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787879, Length=146, Percent_Identity=29.4520547945205, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787601, Length=173, Percent_Identity=24.8554913294798, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788748, Length=120, Percent_Identity=34.1666666666667, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35280; Mature: 35280

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDRASQMVIFYALAKAGSFTAAAKQMGVSTSHVSKQLGALEETLNLKLVHRTTRSLILT
CCCCHHHEEHEEEHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEHHHHHEEEE
DAGQQFFLYCETIYNAMTEASAIMDDERDEVAGILRLGLSQSFGTMHIIPAIDKLRNQYP
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCC
DLQVEVRLFDHQADMLKDGLDLWVTNFEDLPEGYVAQRLADSNFVLAASPDYLIDKKVPH
CCEEEEEEECCHHHHHHCCHHHEECCHHHCCHHHHHHHHCCCCEEEEECCCCEECCCCCC
HPLDLVEHNCLTYQSRYRDYSNWDFSKGNESLCVKVSGNYRVDLAEAVRDATISGWGIAY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCHHHHH
LASYLLTNEFNDGKLIQLLPGWKASQKMPIYAVYPSRKHLPRKISAVIDFLREHIGQPPY
HHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
WDKALMKRVKL
HHHHHHHHHCC
>Mature Secondary Structure
MHDRASQMVIFYALAKAGSFTAAAKQMGVSTSHVSKQLGALEETLNLKLVHRTTRSLILT
CCCCHHHEEHEEEHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCEEEEEHHHHHEEEE
DAGQQFFLYCETIYNAMTEASAIMDDERDEVAGILRLGLSQSFGTMHIIPAIDKLRNQYP
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCC
DLQVEVRLFDHQADMLKDGLDLWVTNFEDLPEGYVAQRLADSNFVLAASPDYLIDKKVPH
CCEEEEEEECCHHHHHHCCHHHEECCHHHCCHHHHHHHHCCCCEEEEECCCCEECCCCCC
HPLDLVEHNCLTYQSRYRDYSNWDFSKGNESLCVKVSGNYRVDLAEAVRDATISGWGIAY
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCEEEEHHHHHHHCCCCCHHHHH
LASYLLTNEFNDGKLIQLLPGWKASQKMPIYAVYPSRKHLPRKISAVIDFLREHIGQPPY
HHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCC
WDKALMKRVKL
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]