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The map label for this gene is cynR [H]

Identifier: 59711670

GI number: 59711670

Start: 1174858

End: 1175754

Strand: Direct

Name: cynR [H]

Synonym: VF_1063

Alternate gene names: 59711670

Gene position: 1174858-1175754 (Clockwise)

Preceding gene: 59711668

Following gene: 59711671

Centisome position: 40.55

GC content: 39.35

Gene sequence:

>897_bases
ATGAGCATGTTAGATCTTCACTGGCTGAAAACCTTCGTGACATTGGCAGAGTTAAAGCATTTTGGTAAAACAGCAGCAGC
ATTACATATGACACAGCCCAATGTTAGTTTGCATATCAAACAGTTAGAAGCTGCAACCCGCGTGAAATTGATAGAGAGAA
ATCCTTTTCATTTAACGGAAGCGGGCAATCGCTTATTAATGACGAGCCAAAATACGTTAATGGAGTTGCAAGTATGCCAA
GCGGATTTGAATGCGATTAATGATTTGAGTCGAGGAACGTTAACCATTGCAGCAAGCGATATTATCTCGCGTTTATTATT
GATAGGGCCATTTCAATTATTTAAGCAAGAATTTCCAGGAATTGATTTCTCATTGCTTAATACCACCTCTTCACAGGCAT
CTGAGTTAGTAAAAAGTGCAGAGGCTGATTTGGGCTTTGTTATTGCCCAGAAAGAGAGCCAACCTCTGCATTTTACCGAA
TTGCAGCAAATAAAATGGTGTGCATTAGGTAATCACCTTGAAGAGTGGCAACAAGCGTATTTGGATCCTACAATTGTTGT
GGATGAAGAACCAACTTTGATTTTGTTAGGGCATGATACTAGAACAAGAGACTTGTTAGACTTGGCGTTACCTTCATTGA
AATTACCCAAATATCGAATCATGGAAGTGGGTAGTGTCGATGCCCAAATAGATTGGGCTGAAGCTGGGTTTGGGGTAGCG
ATTGTGCCTGAGTTTTCTATTCATCCAAAGAGAGATCTTAAAACAAAAGTAACGCCATTACCTGAATTCCCGACAACAAG
TTTAGGCTATATAGTTCGTCAAAATCAGATTTTATCTAAGGCAATTAAACAATTATTAAAGTGGGTGGATGACGAGATTA
TTCGCTCTCAAAAGTAG

Upstream 100 bases:

>100_bases
ATCCTAATATCAGATTTGCAATATGAGAAATTAATTATAATTATCGACTTGATAAGAAATCCATATATCATATTGAGTGA
AATATATTCAAAAAGAGAGT

Downstream 100 bases:

>100_bases
ACATTATTTATCGTTTTACATTGAATTTAAACTGTCTGGTTTGTCAGAAATGGTGTGGCATTTATGATACTGATTATCAT
TTTAAAGACAGTTATGCTCT

Product: transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSMLDLHWLKTFVTLAELKHFGKTAAALHMTQPNVSLHIKQLEAATRVKLIERNPFHLTEAGNRLLMTSQNTLMELQVCQ
ADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTE
LQQIKWCALGNHLEEWQQAYLDPTIVVDEEPTLILLGHDTRTRDLLDLALPSLKLPKYRIMEVGSVDAQIDWAEAGFGVA
IVPEFSIHPKRDLKTKVTPLPEFPTTSLGYIVRQNQILSKAIKQLLKWVDDEIIRSQK

Sequences:

>Translated_298_residues
MSMLDLHWLKTFVTLAELKHFGKTAAALHMTQPNVSLHIKQLEAATRVKLIERNPFHLTEAGNRLLMTSQNTLMELQVCQ
ADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTE
LQQIKWCALGNHLEEWQQAYLDPTIVVDEEPTLILLGHDTRTRDLLDLALPSLKLPKYRIMEVGSVDAQIDWAEAGFGVA
IVPEFSIHPKRDLKTKVTPLPEFPTTSLGYIVRQNQILSKAIKQLLKWVDDEIIRSQK
>Mature_297_residues
SMLDLHWLKTFVTLAELKHFGKTAAALHMTQPNVSLHIKQLEAATRVKLIERNPFHLTEAGNRLLMTSQNTLMELQVCQA
DLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPGIDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTEL
QQIKWCALGNHLEEWQQAYLDPTIVVDEEPTLILLGHDTRTRDLLDLALPSLKLPKYRIMEVGSVDAQIDWAEAGFGVAI
VPEFSIHPKRDLKTKVTPLPEFPTTSLGYIVRQNQILSKAIKQLLKWVDDEIIRSQK

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=165, Percent_Identity=30.9090909090909, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693105, Length=307, Percent_Identity=24.7557003257329, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=300, Percent_Identity=25.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790208, Length=258, Percent_Identity=27.5193798449612, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33539; Mature: 33408

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMLDLHWLKTFVTLAELKHFGKTAAALHMTQPNVSLHIKQLEAATRVKLIERNPFHLTE
CCCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCEEEHHHHHHHHHHEEECCCCEEEEC
AGNRLLMTSQNTLMELQVCQADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCC
IDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTELQQIKWCALGNHLEEWQQAY
CCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
LDPTIVVDEEPTLILLGHDTRTRDLLDLALPSLKLPKYRIMEVGSVDAQIDWAEAGFGVA
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHCCCCCEE
IVPEFSIHPKRDLKTKVTPLPEFPTTSLGYIVRQNQILSKAIKQLLKWVDDEIIRSQK
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SMLDLHWLKTFVTLAELKHFGKTAAALHMTQPNVSLHIKQLEAATRVKLIERNPFHLTE
CCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCEEEHHHHHHHHHHEEECCCCEEEEC
AGNRLLMTSQNTLMELQVCQADLNAINDLSRGTLTIAASDIISRLLLIGPFQLFKQEFPG
CCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCHHHHHHHCCC
IDFSLLNTTSSQASELVKSAEADLGFVIAQKESQPLHFTELQQIKWCALGNHLEEWQQAY
CCEEEECCCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
LDPTIVVDEEPTLILLGHDTRTRDLLDLALPSLKLPKYRIMEVGSVDAQIDWAEAGFGVA
CCCEEEECCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHCCCCCEE
IVPEFSIHPKRDLKTKVTPLPEFPTTSLGYIVRQNQILSKAIKQLLKWVDDEIIRSQK
EECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]