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The map label for this gene is hisI [H]

Identifier: 59711626

GI number: 59711626

Start: 1125662

End: 1126282

Strand: Direct

Name: hisI [H]

Synonym: VF_1019

Alternate gene names: 59711626

Gene position: 1125662-1126282 (Clockwise)

Preceding gene: 59711625

Following gene: 59711627

Centisome position: 38.85

GC content: 41.87

Gene sequence:

>621_bases
ATGAGCCAACAAGAATTAGCAACACGTATTGATTGGGAAAAAGTGGATGGTTTAGTACCTGCAATTATTCAAGATTTTGG
TTCAAGCCAAGTGTTGATGATGGGATACATGAACCAAGATGCTTTGGCTAAAACATTAGAGACAGAAAAAGTCACATTTT
TCTCACGTACTAAAAATCGTTTATGGACTAAAGGCGAAGAGTCCGGCAACAGCTTGAACTTAGTTAATATTTCACTGGAT
TGTGATAACGACACGCTGCTTATTAAAGTAAACCCAGTTGGTCCAACGTGCCATACAGGAACAACAACGTGTTGGGATGG
CGATAAAACCGAAGAAACCCAATTGGTGTGGCTTCATCAGTTGGAACAGCTACTTGCCGAGCGTAAGAATGCTGATCCTG
ATTCATCTTACACAGCAAGTCTCTATGCCCGTGGCACCAAACGTATTTCGCAAAAAGTTGGCGAAGAAGGCGTTGAAGTC
GCGCTTGCAGCGACGTCGGGTGACAAGGCGGAGCTAGTATGTGAATCAGCGGATCTGATCTATCATTTATTTGTGTTATT
GCAAGATCAAGGCTTATCGTTTGATGATGTGATTAATAAATTGAAAGAGCGTCATAAGTAG

Upstream 100 bases:

>100_bases
ACGTAGACGGTGCATTAGCGGCATCGGTATTTCACAAACAAATCATCAATATTGGTGAATTAAAAGACTATTTAGCCGAA
CAGGATGTAGAGGTACGCCG

Downstream 100 bases:

>100_bases
CTCTTTCAATTGAACAGTAACAAAATAACGCCGATCACCTGATCGGCGTTTTTATTGGAATTGAGTAACTATCCTCGCTA
TACTCTGCGCTCAATTTTAG

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSQQELATRIDWEKVDGLVPAIIQDFGSSQVLMMGYMNQDALAKTLETEKVTFFSRTKNRLWTKGEESGNSLNLVNISLD
CDNDTLLIKVNPVGPTCHTGTTTCWDGDKTEETQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEV
ALAATSGDKAELVCESADLIYHLFVLLQDQGLSFDDVINKLKERHK

Sequences:

>Translated_206_residues
MSQQELATRIDWEKVDGLVPAIIQDFGSSQVLMMGYMNQDALAKTLETEKVTFFSRTKNRLWTKGEESGNSLNLVNISLD
CDNDTLLIKVNPVGPTCHTGTTTCWDGDKTEETQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEV
ALAATSGDKAELVCESADLIYHLFVLLQDQGLSFDDVINKLKERHK
>Mature_205_residues
SQQELATRIDWEKVDGLVPAIIQDFGSSQVLMMGYMNQDALAKTLETEKVTFFSRTKNRLWTKGEESGNSLNLVNISLDC
DNDTLLIKVNPVGPTCHTGTTTCWDGDKTEETQLVWLHQLEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVA
LAATSGDKAELVCESADLIYHLFVLLQDQGLSFDDVINKLKERHK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=65.989847715736, Blast_Score=269, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6319819, Length=207, Percent_Identity=31.8840579710145, Blast_Score=90, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22983; Mature: 22852

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQELATRIDWEKVDGLVPAIIQDFGSSQVLMMGYMNQDALAKTLETEKVTFFSRTKNR
CCHHHHHHHCCHHHHHCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEHHHHHH
LWTKGEESGNSLNLVNISLDCDNDTLLIKVNPVGPTCHTGTTTCWDGDKTEETQLVWLHQ
CCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHH
LEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECHHHHH
YHLFVLLQDQGLSFDDVINKLKERHK
HHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SQQELATRIDWEKVDGLVPAIIQDFGSSQVLMMGYMNQDALAKTLETEKVTFFSRTKNR
CHHHHHHHCCHHHHHCHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHEEHHHHHH
LWTKGEESGNSLNLVNISLDCDNDTLLIKVNPVGPTCHTGTTTCWDGDKTEETQLVWLHQ
CCCCCCCCCCEEEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEECCCCCCCHHHHHHHH
LEQLLAERKNADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLI
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECHHHHH
YHLFVLLQDQGLSFDDVINKLKERHK
HHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]