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The map label for this gene is hisB [H]

Identifier: 59711622

GI number: 59711622

Start: 1122362

End: 1123435

Strand: Direct

Name: hisB [H]

Synonym: VF_1015

Alternate gene names: 59711622

Gene position: 1122362-1123435 (Clockwise)

Preceding gene: 59711621

Following gene: 59711623

Centisome position: 38.74

GC content: 41.9

Gene sequence:

>1074_bases
GTGAGCAAACAACAAAAGATTTTATTTATCGACCGTGATGGCACCTTAATTGTTGAGCCGCCGGTGGATTTTCAAGTAGA
CCGTTTAGATAAGCTAAAGTTTGAGCCTTTGGTTATTCCTTCTCTACTTTCTCTTCAAGATGCCGGTTACCGTTTAGTTA
TGGTGACGAACCAAGACGGTTTAGGTACAGATAGCTACCCTCAGGATGAGTTTGATGCACCACATAATATGATGATGGAG
TTTTTTGAATCTCAAGGGGTGAAGTTTGATGATGTTCTTATTTGTCCACACTTTGAAGAAGATAATTGCTCATGTCGTAA
ACCCAAATTAGGCATGGTTAAAGAATACCTTCAAGGTGGAAGAGTCGATTTTCAACACTCAGTTGTGATTGGTGATCGCC
AAACGGATCTTCAATTAGCTGAAAACATGGCGATCCGTGGTATTCAGTATCATCCAGAAACGATGAACTGGCCTGCGATC
TTAAAAGATCTGACCGTAAATGCGCGTACTGCAGAAGTAATACGCACAACCAAAGAAACGGACATTAAAGTGTTTGTTAA
TCTGGATGAGCAAGGCGGCAATGAGATCACTACTGGTCTTGGTTTCTTTGATCACATGCTTGATCAGATTGCTACACACG
GCGGTTTCCAAATGAAAATCAATGTAGAGGGCGACTTACACATTGATGATCACCATACCATTGAAGATACAGCTCTTGCA
TTGGGAGAAGCGTTAAAAGAGGCGCTAGGCGACAAGCGTGGTATTGGTCGTTTTGGATTCAGCTTGCCAATGGATGAGTG
TTTAGCACAATGTGCGCTTGATTTATCTGGTCGTCCATATCTGAAGTTTGATGCTGAATTTAGCCGTGAGCAGGTAGGAG
ATTTATCAACCGAAATGGTAGTTCACTTCTTCCGCTCTCTAACGGATACTCTTGCTTGTACGTTACACCTTTCTTCATCA
GGTTATAACGATCACCACATTATTGAAAGCCTATTTAAAGCGTTTGGTCGTACGTTACGCCAAGCGATTAAAGTAGAAGG
TAATGAACTGCCAAGCTCAAAAGGCGTATTGTAG

Upstream 100 bases:

>100_bases
TCATTTACTTACTGTGATTGGTATATGTTATCCCCAAGCTTAGGAATAAGGCTTGGGGCTTATCAAGAATAAAATTAGAA
AAAATTAAAAGGACGTTCCT

Downstream 100 bases:

>100_bases
GAGTGACTATGACAAATCAAAACGTCGTTATTATTGATACGGGTTGTTCTAACGTTTCATCAGTGAGATTTGCGATTGAG
CGTTTGGGTTACGAGGTTAC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKFEPLVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQDEFDAPHNMMME
FFESQGVKFDDVLICPHFEEDNCSCRKPKLGMVKEYLQGGRVDFQHSVVIGDRQTDLQLAENMAIRGIQYHPETMNWPAI
LKDLTVNARTAEVIRTTKETDIKVFVNLDEQGGNEITTGLGFFDHMLDQIATHGGFQMKINVEGDLHIDDHHTIEDTALA
LGEALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAEFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSS
GYNDHHIIESLFKAFGRTLRQAIKVEGNELPSSKGVL

Sequences:

>Translated_357_residues
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKFEPLVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQDEFDAPHNMMME
FFESQGVKFDDVLICPHFEEDNCSCRKPKLGMVKEYLQGGRVDFQHSVVIGDRQTDLQLAENMAIRGIQYHPETMNWPAI
LKDLTVNARTAEVIRTTKETDIKVFVNLDEQGGNEITTGLGFFDHMLDQIATHGGFQMKINVEGDLHIDDHHTIEDTALA
LGEALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAEFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSS
GYNDHHIIESLFKAFGRTLRQAIKVEGNELPSSKGVL
>Mature_356_residues
SKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKFEPLVIPSLLSLQDAGYRLVMVTNQDGLGTDSYPQDEFDAPHNMMMEF
FESQGVKFDDVLICPHFEEDNCSCRKPKLGMVKEYLQGGRVDFQHSVVIGDRQTDLQLAENMAIRGIQYHPETMNWPAIL
KDLTVNARTAEVIRTTKETDIKVFVNLDEQGGNEITTGLGFFDHMLDQIATHGGFQMKINVEGDLHIDDHHTIEDTALAL
GEALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAEFSREQVGDLSTEMVVHFFRSLTDTLACTLHLSSSG
YNDHHIIESLFKAFGRTLRQAIKVEGNELPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=353, Percent_Identity=69.971671388102, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1786399, Length=150, Percent_Identity=30.6666666666667, Blast_Score=73, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324776, Length=165, Percent_Identity=49.0909090909091, Blast_Score=161, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 40115; Mature: 39984

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKFEPLVIPSLLSLQDAGYRLVMVTNQDG
CCCCCEEEEEECCCCEEECCCCCCCCCCHHHCCCCCEEHHHHHHHCCCCEEEEEEECCCC
LGTDSYPQDEFDAPHNMMMEFFESQGVKFDDVLICPHFEEDNCSCRKPKLGMVKEYLQGG
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCC
RVDFQHSVVIGDRQTDLQLAENMAIRGIQYHPETMNWPAILKDLTVNARTAEVIRTTKET
CCEEEEEEEECCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCCCCHHHHHHHHCCCC
DIKVFVNLDEQGGNEITTGLGFFDHMLDQIATHGGFQMKINVEGDLHIDDHHTIEDTALA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHH
LGEALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAEFSREQVGDLSTEMV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCHHHHHH
VHFFRSLTDTLACTLHLSSSGYNDHHIIESLFKAFGRTLRQAIKVEGNELPSSKGVL
HHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQQKILFIDRDGTLIVEPPVDFQVDRLDKLKFEPLVIPSLLSLQDAGYRLVMVTNQDG
CCCCEEEEEECCCCEEECCCCCCCCCCHHHCCCCCEEHHHHHHHCCCCEEEEEEECCCC
LGTDSYPQDEFDAPHNMMMEFFESQGVKFDDVLICPHFEEDNCSCRKPKLGMVKEYLQGG
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCC
RVDFQHSVVIGDRQTDLQLAENMAIRGIQYHPETMNWPAILKDLTVNARTAEVIRTTKET
CCEEEEEEEECCCCHHHHHHHHHHHCCEEECCCCCCCHHHHHHHCCCCHHHHHHHHCCCC
DIKVFVNLDEQGGNEITTGLGFFDHMLDQIATHGGFQMKINVEGDLHIDDHHTIEDTALA
CEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHH
LGEALKEALGDKRGIGRFGFSLPMDECLAQCALDLSGRPYLKFDAEFSREQVGDLSTEMV
HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCHHHHHH
VHFFRSLTDTLACTLHLSSSGYNDHHIIESLFKAFGRTLRQAIKVEGNELPSSKGVL
HHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]