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The map label for this gene is serS [H]

Identifier: 59711515

GI number: 59711515

Start: 1002515

End: 1003822

Strand: Direct

Name: serS [H]

Synonym: VF_0908

Alternate gene names: 59711515

Gene position: 1002515-1003822 (Clockwise)

Preceding gene: 59711514

Following gene: 59711518

Centisome position: 34.6

GC content: 43.35

Gene sequence:

>1308_bases
ATGCTTGATTCAAAATTACTTCGTACAGAGCTGGATGAAACAGCTGAAAAACTGGCACGTCGTGGCTTTAAGCTAGACGT
AGAGACACTTCGCAACCTTGAAGAACAACGTAAGTCCCTTCAAGTAAAAACTGAAGAGCTTCAAGCGCAGCGTAACTCCC
GTTCGAAGTCCATTGGTCAAGCAAAAGCGAAAGGTGATCACGAAGAAGCTGATCGCATTATGGCTGATGTTGCGAATCTG
GGTTCTGAACTGGATGAAGCAAAAGCAGCACTAGCAGAGCTTCAACAACAAATCGAAGACATCGCGCTTTCTGTACCTAA
CATCCCTGATGATTCAGTGCCACTAGGTAAAGATGAGAACGAAAACGTAGAAGTATTACGTTGGGGTACACCTTTAGCGT
ATGACTTTGAAGTTAAAGATCACGTTGATCTAGGTGAAATGGCTGATGGTCTTGATTTCGCAAGTGCGGTGAAGATCTCT
GGTTCTCGTTTCATCGTAATGAAAGGTCAATTTGCTCGCCTTCACCGTGCTCTTTCTCAGTTCATGCTTGATCTTCACAC
TGAAGAGCATGGCTACACAGAAATGTACGTACCATACCTTGTAAACCCAGATAGCCTATTTGGTACTGGCCAGCTTCCTA
AGTTTGGTGAAGACTTGTTCCACACAAGCCCACTAACTGAGCAAGTAAGTGATGTTCCACTTAAGAAACTATCACTTATC
CCAACAGCTGAAGTTCCAGTAACTAACATGGTGCGCGATACCATTACTGATGAAGCTGATATGCCACTTAAGATGACGGC
TCACACTCCATGTTTCCGTTCTGAAGCGGGTTCTTACGGTCGTGATACGCGTGGTCTTATTCGTATGCACCAATTCGACA
AAGTTGAATTAGTACAAATCACTAAACCTGAAGATTCAATGGCTGCACTTGAAGAACTAACAGGTCATGCTGAGAAAGTT
CTTCAACTATTAGAACTTCCTTACCGTAAAGTGGTTTTATGTACAGGTGATATGGGCTTCGGCTCTCGTAAAACTTACGA
TTTAGAAGTATGGGTTCCAGCACAAGAAACGTACCGTGAAATCTCTTCTTGTTCAAACATGTGGGATTTCCAAGCTCGTC
GTATGCAAGCTCGTTTCCGTCGTAAAGGCGAGAAAAAACCTGAACTTGTGCATACACTAAACGGTTCTGGTCTTGCTGTA
GGTCGTACAATGGTTGCGATTCTTGAGAACTTCCAACAAGCTGATGGTAAAATTGCAATCCCACAAGTACTACGTAAGTA
CATGAATGGTGTTGAGTTCATCGGTTAA

Upstream 100 bases:

>100_bases
TTCGAATCGCAATTTGGAAATGAAAATTGCACAGGATTTTATTATTAAGTGGGTTCTTTTTATTTTGAACACACCATTAC
TATAAGGCATAGGATTACAA

Downstream 100 bases:

>100_bases
TCTATATTAATAGATAACACATAATAAATAGTAAAAAGCCCCTTTATGCAGAGTCATAAAGGGGCTTTTTGTTTGTCTGC
TATTTACATTATTTAAGCAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRNLEEQRKSLQVKTEELQAQRNSRSKSIGQAKAKGDHEEADRIMADVANL
GSELDEAKAALAELQQQIEDIALSVPNIPDDSVPLGKDENENVEVLRWGTPLAYDFEVKDHVDLGEMADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYTEMYVPYLVNPDSLFGTGQLPKFGEDLFHTSPLTEQVSDVPLKKLSLI
PTAEVPVTNMVRDTITDEADMPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVVLCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPQVLRKYMNGVEFIG

Sequences:

>Translated_435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRNLEEQRKSLQVKTEELQAQRNSRSKSIGQAKAKGDHEEADRIMADVANL
GSELDEAKAALAELQQQIEDIALSVPNIPDDSVPLGKDENENVEVLRWGTPLAYDFEVKDHVDLGEMADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYTEMYVPYLVNPDSLFGTGQLPKFGEDLFHTSPLTEQVSDVPLKKLSLI
PTAEVPVTNMVRDTITDEADMPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVVLCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPQVLRKYMNGVEFIG
>Mature_435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRNLEEQRKSLQVKTEELQAQRNSRSKSIGQAKAKGDHEEADRIMADVANL
GSELDEAKAALAELQQQIEDIALSVPNIPDDSVPLGKDENENVEVLRWGTPLAYDFEVKDHVDLGEMADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYTEMYVPYLVNPDSLFGTGQLPKFGEDLFHTSPLTEQVSDVPLKKLSLI
PTAEVPVTNMVRDTITDEADMPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVVLCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPQVLRKYMNGVEFIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=435, Percent_Identity=33.1034482758621, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI8923421, Length=404, Percent_Identity=28.2178217821782, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI225579074, Length=340, Percent_Identity=30, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=74.0229885057471, Blast_Score=677, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=436, Percent_Identity=30.7339449541284, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=343, Percent_Identity=27.4052478134111, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321799, Length=419, Percent_Identity=31.2649164677804, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6320226, Length=409, Percent_Identity=31.5403422982885, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24581334, Length=345, Percent_Identity=36.231884057971, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737985, Length=275, Percent_Identity=32.7272727272727, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48959; Mature: 48959

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRTELDETAEKLARRGFKLDVETLRNLEEQRKSLQVKTEELQAQRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEADRIMADVANLGSELDEAKAALAELQQQIEDIALSVPNIPDDSVPLGKDEN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENVEVLRWGTPLAYDFEVKDHVDLGEMADGLDFASAVKISGSRFIVMKGQFARLHRALSQ
CCEEEEECCCCEEEEECCCCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYTEMYVPYLVNPDSLFGTGQLPKFGEDLFHTSPLTEQVSDVPLKKLSLI
HHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCHHHHCCC
PTAEVPVTNMVRDTITDEADMPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVVLCTGDMGFGSRKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENFQQADGKIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEH
PQVLRKYMNGVEFIG
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDSKLLRTELDETAEKLARRGFKLDVETLRNLEEQRKSLQVKTEELQAQRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEADRIMADVANLGSELDEAKAALAELQQQIEDIALSVPNIPDDSVPLGKDEN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENVEVLRWGTPLAYDFEVKDHVDLGEMADGLDFASAVKISGSRFIVMKGQFARLHRALSQ
CCEEEEECCCCEEEEECCCCCCCHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYTEMYVPYLVNPDSLFGTGQLPKFGEDLFHTSPLTEQVSDVPLKKLSLI
HHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCHHHHCCC
PTAEVPVTNMVRDTITDEADMPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVVLCTGDMGFGSRKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENFQQADGKIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCEEH
PQVLRKYMNGVEFIG
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA