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The map label for this gene is sdhB [H]

Identifier: 59711429

GI number: 59711429

Start: 901207

End: 901920

Strand: Direct

Name: sdhB [H]

Synonym: VF_0822

Alternate gene names: 59711429

Gene position: 901207-901920 (Clockwise)

Preceding gene: 59711428

Following gene: 59711430

Centisome position: 31.1

GC content: 38.24

Gene sequence:

>714_bases
ATGAAATTGAATTTTTCGATCTACCGCTATAATCCAGATGTAGATAATGCACCTCACATGAAAGCATACACATTAGATGT
TGAAGAAGGTTCAGATATGATGGTGCTTGATGCACTTATCTTATTAAAAGAACAAGACCCAACATTAGCTTTCCGCCGTT
CATGTCGTGAGGGGGTGTGTGGTTCTGATGGTCTTAATATGAATGGTAAAAATGGACTTGCATGCATTACGCCATTATCT
GAATTAGCAGATAAAAGTGAGATTGTTATTCGTCCATTGCCTGGTTTGCCTGTTGTTCGAGATTTGATTGTCGATATGGC
ACAATTCTATGAAAATTATGAAAAGGTAAAACCGTTCTTAATTAGTGATGGAGCAACGCCACCTTCAAGAGAAAACCTAC
AATCTCCAGAAGAGCGTGAGCATCTAGATGGTTTGTATGAATGCATCATGTGTGCATGTTGTACTACCTCGTGCCCATCA
TTTTGGTGGAATCCTGATAAATTCATCGGACCAGCAGGGTTGCTTGCAGCTTATCGTTGGTTAATTGATAGTCGAGATAC
TGCAACAAATGAACGTTTATCTAATTTAGATGATGCATTCAGTGTTTTTCGTTGCCATGGTATCATGAATTGTGTAAGTG
TATGTCCTAAAGGGTTAAACCCAACAAAAGCAATTGGTCATATAAAGACAATGCTATTGAAAAAAGCGGTATAA

Upstream 100 bases:

>100_bases
CCCTGAGACAGAATCAATGTCTAAGCGTAATGTAAATATGGAACCTGTTCACCGTGAAGCTTTCCCTCCGAAAGCTCGTA
CATATTAAGAGGGCAGAAGA

Downstream 100 bases:

>100_bases
TTTACTTTTCCTCAACCTATGTTGATAGGTTGAGGCTTATTATAAGCCCGGCACAAAGACCGGGATAGACGTGAAACTAC
TGGATTAAGGGAAAATAATG

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLDVEEGSDMMVLDALILLKEQDPTLAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELADKSEIVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV

Sequences:

>Translated_237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLDVEEGSDMMVLDALILLKEQDPTLAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELADKSEIVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
>Mature_237_residues
MKLNFSIYRYNPDVDNAPHMKAYTLDVEEGSDMMVLDALILLKEQDPTLAFRRSCREGVCGSDGLNMNGKNGLACITPLS
ELADKSEIVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFLISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPS
FWWNPDKFIGPAGLLAAYRWLIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=54.3103448275862, Blast_Score=261, Evalue=5e-70,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=77.1186440677966, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1790596, Length=229, Percent_Identity=37.117903930131, Blast_Score=157, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=52.1551724137931, Blast_Score=249, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6322987, Length=231, Percent_Identity=51.5151515151515, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137106, Length=233, Percent_Identity=54.9356223175966, Blast_Score=262, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24643156, Length=233, Percent_Identity=51.5021459227468, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26442; Mature: 26442

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
8.4 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
8.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNFSIYRYNPDVDNAPHMKAYTLDVEEGSDMMVLDALILLKEQDPTLAFRRSCREGVC
CCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSELADKSEIVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFL
CCCCCCCCCCCCEEEECCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEE
ISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRW
EECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
LIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLNFSIYRYNPDVDNAPHMKAYTLDVEEGSDMMVLDALILLKEQDPTLAFRRSCREGVC
CCCEEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCC
GSDGLNMNGKNGLACITPLSELADKSEIVIRPLPGLPVVRDLIVDMAQFYENYEKVKPFL
CCCCCCCCCCCCEEEECCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEE
ISDGATPPSRENLQSPEEREHLDGLYECIMCACCTTSCPSFWWNPDKFIGPAGLLAAYRW
EECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHH
LIDSRDTATNERLSNLDDAFSVFRCHGIMNCVSVCPKGLNPTKAIGHIKTMLLKKAV
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]