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The map label for this gene is ribD [H]

Identifier: 59711307

GI number: 59711307

Start: 768141

End: 769259

Strand: Direct

Name: ribD [H]

Synonym: VF_0700

Alternate gene names: 59711307

Gene position: 768141-769259 (Clockwise)

Preceding gene: 59711306

Following gene: 59711308

Centisome position: 26.51

GC content: 40.3

Gene sequence:

>1119_bases
ATGACATTTACTACCCAAGATCATCTGATGATGCAAAAAGCTATCTTATTAGCTAAGCAAGGCATTTATACCACAGCCCC
TAATCCAAATGTGGGGTGTGTATTGGTTAAAAATGGGAAGATTATTGGGGAAGGGGCGCACTTAAAAGCAGGTGAACCCC
ATGCTGAAGTCCATGCATTAAGACAAGCAGGAAAAGAAGCGCAAGGGGCAACGGCTTATGTGACGCTTGAACCTTGCTCT
CATTATGGACGCACACCACCTTGTGCTGAAGGACTTATAAAAGCGGGCGTAAAAAAAGTAATTTGTGCGATGGTTGATCC
AAACCCTCAAGTTGCTGGTCGTGGTCTTGCTATGTTAGATGAAGCTGGAATTGAAACCGCATCAGGTCTGCTTGAAGCCG
ATGCTAGAGCCTTAAACCCTCACTTTTTAACTCGAATGGAAACTGGAAAACCATTTGTACAGTTAAAAATGGCAGCGAGT
CTTGATGGAAAAACCGCATTAAAAAATGGAGTGAGTCAATGGATCACTTCAAAAGAAGCAAGACAAGATGTTCAACGCTA
TCGTGCACAATCTGGTGCAATACTCTCAACAGCGAAAACCGTGATTGATGATGACGCCTCATTAAATGTGCGTTGGAGTG
ATCTTCCTCCCTCAATTCAAGAAAGCTACCAACAAGCGTCTATTCGACAGCCAATGCGTTTTATTTTAGATCGTCAGCAT
TCATTAACATCTGATTTAAAACTGTTTCAAGCCTCTGATGAAGTAGTTACGATCTCATCTCAAAACACACATCCAATAGG
GACTTCTGAAAATCATATGCAATGCCGTGTTGATGATGGTCAATTGGATCTTAAAGAAGTCGTAAATAAAATTTCTCGTG
ATTTTAATGTAAATCATATTTGGGTAGAAGCCGGTGCGACATTAGCAGCAAGTATGATTAACGATAATTTAGTTGATGAA
TTGATTATTTATCTCGCCCCTAAATTAATGGGAGCGGATGGGCGTAGTATCATTAATTTAATTGGATTAGAAACGATGTC
TGAGGCAATTGACTTGGATATAAAAGACATACGTATGGTCGGTAAAGATATTCGAATTACCGCAACAATAGCAAGGTAA

Upstream 100 bases:

>100_bases
GAGCTCGATAAAGTGGCTTATATTCGTTTTGCCTCTGTTTACCGAAGCTTTGAAGATATTAAAGAGTTCGGTGAAGAAAT
TGCAAAACTAGAGAAATAAC

Downstream 100 bases:

>100_bases
CCCATGTTTACAGGAATTATTGAGTCAGTAGGTATACTGCAAGCCATTACACCAAAGGGTGAAGATATTAGCGTAACGGT
TAATGTTGGTCAGTTAGACA

Product: fused diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MTFTTQDHLMMQKAILLAKQGIYTTAPNPNVGCVLVKNGKIIGEGAHLKAGEPHAEVHALRQAGKEAQGATAYVTLEPCS
HYGRTPPCAEGLIKAGVKKVICAMVDPNPQVAGRGLAMLDEAGIETASGLLEADARALNPHFLTRMETGKPFVQLKMAAS
LDGKTALKNGVSQWITSKEARQDVQRYRAQSGAILSTAKTVIDDDASLNVRWSDLPPSIQESYQQASIRQPMRFILDRQH
SLTSDLKLFQASDEVVTISSQNTHPIGTSENHMQCRVDDGQLDLKEVVNKISRDFNVNHIWVEAGATLAASMINDNLVDE
LIIYLAPKLMGADGRSIINLIGLETMSEAIDLDIKDIRMVGKDIRITATIAR

Sequences:

>Translated_372_residues
MTFTTQDHLMMQKAILLAKQGIYTTAPNPNVGCVLVKNGKIIGEGAHLKAGEPHAEVHALRQAGKEAQGATAYVTLEPCS
HYGRTPPCAEGLIKAGVKKVICAMVDPNPQVAGRGLAMLDEAGIETASGLLEADARALNPHFLTRMETGKPFVQLKMAAS
LDGKTALKNGVSQWITSKEARQDVQRYRAQSGAILSTAKTVIDDDASLNVRWSDLPPSIQESYQQASIRQPMRFILDRQH
SLTSDLKLFQASDEVVTISSQNTHPIGTSENHMQCRVDDGQLDLKEVVNKISRDFNVNHIWVEAGATLAASMINDNLVDE
LIIYLAPKLMGADGRSIINLIGLETMSEAIDLDIKDIRMVGKDIRITATIAR
>Mature_371_residues
TFTTQDHLMMQKAILLAKQGIYTTAPNPNVGCVLVKNGKIIGEGAHLKAGEPHAEVHALRQAGKEAQGATAYVTLEPCSH
YGRTPPCAEGLIKAGVKKVICAMVDPNPQVAGRGLAMLDEAGIETASGLLEADARALNPHFLTRMETGKPFVQLKMAASL
DGKTALKNGVSQWITSKEARQDVQRYRAQSGAILSTAKTVIDDDASLNVRWSDLPPSIQESYQQASIRQPMRFILDRQHS
LTSDLKLFQASDEVVTISSQNTHPIGTSENHMQCRVDDGQLDLKEVVNKISRDFNVNHIWVEAGATLAASMINDNLVDEL
IIYLAPKLMGADGRSIINLIGLETMSEAIDLDIKDIRMVGKDIRITATIAR

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=360, Percent_Identity=51.1111111111111, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40458; Mature: 40327

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFTTQDHLMMQKAILLAKQGIYTTAPNPNVGCVLVKNGKIIGEGAHLKAGEPHAEVHAL
CCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCEEEECCCCCCCCCCHHHHHHH
RQAGKEAQGATAYVTLEPCSHYGRTPPCAEGLIKAGVKKVICAMVDPNPQVAGRGLAMLD
HHCCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
EAGIETASGLLEADARALNPHFLTRMETGKPFVQLKMAASLDGKTALKNGVSQWITSKEA
HCCCHHHHHHHHHHHHHCCCHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQDVQRYRAQSGAILSTAKTVIDDDASLNVRWSDLPPSIQESYQQASIRQPMRFILDRQH
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLTSDLKLFQASDEVVTISSQNTHPIGTSENHMQCRVDDGQLDLKEVVNKISRDFNVNHI
HHHHHHHHEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEE
WVEAGATLAASMINDNLVDELIIYLAPKLMGADGRSIINLIGLETMSEAIDLDIKDIRMV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
GKDIRITATIAR
CCCEEEEEEECC
>Mature Secondary Structure 
TFTTQDHLMMQKAILLAKQGIYTTAPNPNVGCVLVKNGKIIGEGAHLKAGEPHAEVHAL
CCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEECCEEEECCCCCCCCCCHHHHHHH
RQAGKEAQGATAYVTLEPCSHYGRTPPCAEGLIKAGVKKVICAMVDPNPQVAGRGLAMLD
HHCCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHH
EAGIETASGLLEADARALNPHFLTRMETGKPFVQLKMAASLDGKTALKNGVSQWITSKEA
HCCCHHHHHHHHHHHHHCCCHHHEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
RQDVQRYRAQSGAILSTAKTVIDDDASLNVRWSDLPPSIQESYQQASIRQPMRFILDRQH
HHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLTSDLKLFQASDEVVTISSQNTHPIGTSENHMQCRVDDGQLDLKEVVNKISRDFNVNHI
HHHHHHHHEECCCCEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCEE
WVEAGATLAASMINDNLVDELIIYLAPKLMGADGRSIINLIGLETMSEAIDLDIKDIRMV
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHC
GKDIRITATIAR
CCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]