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The map label for this gene is gmhB [H]

Identifier: 59711294

GI number: 59711294

Start: 749943

End: 750494

Strand: Direct

Name: gmhB [H]

Synonym: VF_0687

Alternate gene names: 59711294

Gene position: 749943-750494 (Clockwise)

Preceding gene: 59711276

Following gene: 172087676

Centisome position: 25.88

GC content: 39.67

Gene sequence:

>552_bases
TTGTCCAAACCAGCGGTATTTATTGATAGAGATGGCGTGATCAATGTTGATCATGGCTATGTTCATAAACGTGATGATTT
TGAATACATTGATGGTGTATTTGAGGCTACGAAGAAACTCAAAGAAATGGGTTACCTATTAGTGTTGGTAACTAACCAAT
CAGGTATTGCTCGCGGTATGTTCACTGAAGATCAATTTGAAATTCTTACTGAGTGGATGGATTGGAACTTTGCTGATAAT
GGCGTTGACTTTGATGGCATCTATTATTGTCCTCATCACCCTGAAGCCACTGTTGAAAAATACAAAGAAGCATGTGATTG
CCGTAAACCAAATCCAGGTATGTTAGTTTCTGCACAACGTTTCTTAGATATCGACATGGAAAATTCAATCATGATCGGTG
ATAAGAAAGAAGACATGATGGCAGCGCAAGCGGCTAGTGTTGGCACTCGTATTTTAGTTCGAACTGGTAAGCCAGTAACT
GAAGAAGGTGAAGCATTAGCAACTGCAGTTCTTGATAGTGTTGCAGATGTACCAAAGTTCTTGTCTGCTTAG

Upstream 100 bases:

>100_bases
TTTACGTCTAGACGTCTAAACACACAAATAAGATGTCAATAAGTGAAAAGCATGAGATAATTTTTGATATTAACCGATTT
GATTCATAGAGGGTGTCACC

Downstream 100 bases:

>100_bases
CTAGATTTGTTAAAGAGAATATAAATGAAACGCCTATAGAGAAATCTGTGGGCGTTTTTTTATGTGTTAACAATGAATAT
GTTAGCGAGCGTTTTCTTTC

Product: D,D-heptose 1,7-bisphosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSKPAVFIDRDGVINVDHGYVHKRDDFEYIDGVFEATKKLKEMGYLLVLVTNQSGIARGMFTEDQFEILTEWMDWNFADN
GVDFDGIYYCPHHPEATVEKYKEACDCRKPNPGMLVSAQRFLDIDMENSIMIGDKKEDMMAAQAASVGTRILVRTGKPVT
EEGEALATAVLDSVADVPKFLSA

Sequences:

>Translated_183_residues
MSKPAVFIDRDGVINVDHGYVHKRDDFEYIDGVFEATKKLKEMGYLLVLVTNQSGIARGMFTEDQFEILTEWMDWNFADN
GVDFDGIYYCPHHPEATVEKYKEACDCRKPNPGMLVSAQRFLDIDMENSIMIGDKKEDMMAAQAASVGTRILVRTGKPVT
EEGEALATAVLDSVADVPKFLSA
>Mature_182_residues
SKPAVFIDRDGVINVDHGYVHKRDDFEYIDGVFEATKKLKEMGYLLVLVTNQSGIARGMFTEDQFEILTEWMDWNFADNG
VDFDGIYYCPHHPEATVEKYKEACDCRKPNPGMLVSAQRFLDIDMENSIMIGDKKEDMMAAQAASVGTRILVRTGKPVTE
EGEALATAVLDSVADVPKFLSA

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=178, Percent_Identity=66.2921348314607, Blast_Score=264, Evalue=3e-72,
Organism=Escherichia coli, GI87082027, Length=153, Percent_Identity=32.6797385620915, Blast_Score=77, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: NA

Molecular weight: Translated: 20481; Mature: 20350

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPAVFIDRDGVINVDHGYVHKRDDFEYIDGVFEATKKLKEMGYLLVLVTNQSGIARGM
CCCCCEEEECCCEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
FTEDQFEILTEWMDWNFADNGVDFDGIYYCPHHPEATVEKYKEACDCRKPNPGMLVSAQR
CCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEHHH
FLDIDMENSIMIGDKKEDMMAAQAASVGTRILVRTGKPVTEEGEALATAVLDSVADVPKF
HEEECCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LSA
HCC
>Mature Secondary Structure 
SKPAVFIDRDGVINVDHGYVHKRDDFEYIDGVFEATKKLKEMGYLLVLVTNQSGIARGM
CCCCEEEECCCEEECCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCC
FTEDQFEILTEWMDWNFADNGVDFDGIYYCPHHPEATVEKYKEACDCRKPNPGMLVSAQR
CCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEHHH
FLDIDMENSIMIGDKKEDMMAAQAASVGTRILVRTGKPVTEEGEALATAVLDSVADVPKF
HEEECCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
LSA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301; 12101286 [H]