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The map label for this gene is ndk [H]

Identifier: 59711232

GI number: 59711232

Start: 681548

End: 681982

Strand: Direct

Name: ndk [H]

Synonym: VF_0625

Alternate gene names: 59711232

Gene position: 681548-681982 (Clockwise)

Preceding gene: 59711231

Following gene: 59711233

Centisome position: 23.52

GC content: 41.61

Gene sequence:

>435_bases
ATGACAATAGAACGTACTTTTTCAATTGTAAAACCAGATGCCGTTAAGCGTAACTTAATTGGTGCTATTTACCGTCGTAT
TGAAAAAACAGGTATGCAAATCGTTGCTGCTAAAATGCTTCGTTTAACTAAAGAACAAGCAGAAGGCTTTTATGCTGAGC
ATGAAGGAAAAGAGTTTTTTGATGAATTAGTGGCATACATGATGTCAGGACCTGTAATGGTTCAAGTTCTTGAAGGTGAA
AATGCGGTTGTACGCTACCGTGAGCTAATGGGTAAAACTAACCCAGAAGAAGCAGCGTGTGGCTCACTACGAGCGGATTA
TGCAATTAGCATGCGTTACAACTCTGTTCACGGTGCTGATAGCCCAGAATCTGCAGCACGTGAGATTGCGTATTTCTTTG
CTGAAGATGAAATCTGCCCACGTCCAGCGGAATAA

Upstream 100 bases:

>100_bases
TTTGCTATTTCTGAGCATTGACTTACTGTGATTGGTATTAGATAAATAAGTACTGATTGAAATTAATATAAGAAGTAAAA
GAAACCTAAAGGAAAGTAGA

Downstream 100 bases:

>100_bases
TAGGGACGAAAGCCTAAAACGCTTGCAAGCTCCCTAAAGAATAACGGGAGCTTGTTTTGTTGAATGCTAGAACATTGTAA
TTAATTTCAGAATCATTTTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQIVAAKMLRLTKEQAEGFYAEHEGKEFFDELVAYMMSGPVMVQVLEGE
NAVVRYRELMGKTNPEEAACGSLRADYAISMRYNSVHGADSPESAAREIAYFFAEDEICPRPAE

Sequences:

>Translated_144_residues
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQIVAAKMLRLTKEQAEGFYAEHEGKEFFDELVAYMMSGPVMVQVLEGE
NAVVRYRELMGKTNPEEAACGSLRADYAISMRYNSVHGADSPESAAREIAYFFAEDEICPRPAE
>Mature_143_residues
TIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQIVAAKMLRLTKEQAEGFYAEHEGKEFFDELVAYMMSGPVMVQVLEGEN
AVVRYRELMGKTNPEEAACGSLRADYAISMRYNSVHGADSPESAAREIAYFFAEDEICPRPAE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=45.9259259259259, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=41.6058394160584, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40, Blast_Score=116, Evalue=6e-27,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40, Blast_Score=116, Evalue=8e-27,
Organism=Homo sapiens, GI4826862, Length=139, Percent_Identity=38.8489208633094, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=37.2262773722628, Blast_Score=94, Evalue=4e-20,
Organism=Homo sapiens, GI4505413, Length=143, Percent_Identity=37.7622377622378, Blast_Score=93, Evalue=9e-20,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=33.0935251798561, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=33.0935251798561, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=36.2962962962963, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=34.0579710144928, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=65.2482269503546, Blast_Score=198, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=42.2222222222222, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=43.3823529411765, Blast_Score=127, Evalue=6e-31,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.8529411764706, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=35.2941176470588, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 16222; Mature: 16091

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQIVAAKMLRLTKEQAEGFYAEHEGKEFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHH
DELVAYMMSGPVMVQVLEGENAVVRYRELMGKTNPEEAACGSLRADYAISMRYNSVHGAD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEECCCCCCC
SPESAAREIAYFFAEDEICPRPAE
CHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TIERTFSIVKPDAVKRNLIGAIYRRIEKTGMQIVAAKMLRLTKEQAEGFYAEHEGKEFF
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHH
DELVAYMMSGPVMVQVLEGENAVVRYRELMGKTNPEEAACGSLRADYAISMRYNSVHGAD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHCCCCCCEEEEEEECCCCCCC
SPESAAREIAYFFAEDEICPRPAE
CHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA