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The map label for this gene is iscR [H]

Identifier: 59711223

GI number: 59711223

Start: 674040

End: 674546

Strand: Direct

Name: iscR [H]

Synonym: VF_0616

Alternate gene names: 59711223

Gene position: 674040-674546 (Clockwise)

Preceding gene: 59711222

Following gene: 59711224

Centisome position: 23.26

GC content: 41.03

Gene sequence:

>507_bases
ATGAAATTAACTTCAAAGGGAAGGTATGCAGTAACAGCAATGTTAGACGTTGCACTTCATGCCCAAGAAGGACCAGTGCC
GCTTGCTGATATCTCAGAGCGCCAAGGAATTTCATTATCTTATCTTGAACAATTATTCTCTAGATTACGTAAAGCCGGTT
TAGTTGCTAGCGTTCGAGGCCCAGGTGGTGGTTATCGCTTAGGATTAAAAGCTGAGCAAATTGCTGTTGGAATGGTTATT
TCAGCCGTCGATGAATCAGTTGATGCAACGAAATGTCATGGAAAAGAAGGCTGCCAAGGTGGTACGCGTTGTTTAACGCA
CACATTGTGGCGTGATCTAAGTTCTCGAATCAGTACTTTCTTAGACGGTATTACGCTTGGTGAACTGATGCAAGATAATG
AAGTTCAGCAAATATCCGATCGACAAAATGTTGATCTTGCCATAACAAATGGCTTAACTACGAATTCAAAATTAACAAAT
TCTGTGGGTGTTAATGTCCGTTCTTAA

Upstream 100 bases:

>100_bases
TAGTAAGTACTTGACTAAAATAGTAGGATAAATACTTGACCAAAATAGTCAGGTATGGGAAACTTCATTCCATACGAATA
GTGTGGATATGAGGTAACTT

Downstream 100 bases:

>100_bases
CGGTCAAACGTCTGTATTTTTGGAGATGAAAATGAAACTGCCAATTTACTTTGATTATTCGGCTACGTGTCCTGTTGATA
AACGTGTAGCGGATAAAATG

Product: Fe-S cluster synthesis regulatory protein IscR, DNA-binding transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MKLTSKGRYAVTAMLDVALHAQEGPVPLADISERQGISLSYLEQLFSRLRKAGLVASVRGPGGGYRLGLKAEQIAVGMVI
SAVDESVDATKCHGKEGCQGGTRCLTHTLWRDLSSRISTFLDGITLGELMQDNEVQQISDRQNVDLAITNGLTTNSKLTN
SVGVNVRS

Sequences:

>Translated_168_residues
MKLTSKGRYAVTAMLDVALHAQEGPVPLADISERQGISLSYLEQLFSRLRKAGLVASVRGPGGGYRLGLKAEQIAVGMVI
SAVDESVDATKCHGKEGCQGGTRCLTHTLWRDLSSRISTFLDGITLGELMQDNEVQQISDRQNVDLAITNGLTTNSKLTN
SVGVNVRS
>Mature_168_residues
MKLTSKGRYAVTAMLDVALHAQEGPVPLADISERQGISLSYLEQLFSRLRKAGLVASVRGPGGGYRLGLKAEQIAVGMVI
SAVDESVDATKCHGKEGCQGGTRCLTHTLWRDLSSRISTFLDGITLGELMQDNEVQQISDRQNVDLAITNGLTTNSKLTN
SVGVNVRS

Specific function: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins [H]

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=143, Percent_Identity=76.2237762237762, Blast_Score=201, Evalue=3e-53,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010242
- InterPro:   IPR000944
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 18003; Mature: 18003

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTSKGRYAVTAMLDVALHAQEGPVPLADISERQGISLSYLEQLFSRLRKAGLVASVRG
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECC
PGGGYRLGLKAEQIAVGMVISAVDESVDATKCHGKEGCQGGTRCLTHTLWRDLSSRISTF
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LDGITLGELMQDNEVQQISDRQNVDLAITNGLTTNSKLTNSVGVNVRS
HCCCHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MKLTSKGRYAVTAMLDVALHAQEGPVPLADISERQGISLSYLEQLFSRLRKAGLVASVRG
CCCCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEECC
PGGGYRLGLKAEQIAVGMVISAVDESVDATKCHGKEGCQGGTRCLTHTLWRDLSSRISTF
CCCCEEECCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LDGITLGELMQDNEVQQISDRQNVDLAITNGLTTNSKLTNSVGVNVRS
HCCCHHHHHHCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA