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The map label for this gene is emrE [H]

Identifier: 59711191

GI number: 59711191

Start: 642663

End: 643016

Strand: Direct

Name: emrE [H]

Synonym: VF_0584

Alternate gene names: 59711191

Gene position: 642663-643016 (Clockwise)

Preceding gene: 59711190

Following gene: 59711193

Centisome position: 22.18

GC content: 39.27

Gene sequence:

>354_bases
ATGTTTAAATTACTTGTTTCAATGCCGCCTGCGATGGCTCTTATTATTGCGATTATTTCAGAAGTGATTGCAACCTCATT
CATTCCTAAAACCGAGCAATTTACTAAGTTAACACCAAGTTTAATTGTGGCTGTTGGCTATGGCATTGCTTTCTTTTTGC
TGTCTGTAACCGTAAAAAGTATGCCTGTTGGTATTGTTTACGCAATCTGGAGTGGTGCCGGTATCGTCCTTGTTGCCGCG
ATTGGATATTTTGCTTACGGACAGAAGTTAGATCTTGCAGGGATCATTGGGATTAGCTTAATTTTGTCTGGTGTTCTTGT
GGTTAACTTATTATCAAAAACTGCAGGTCATTAG

Upstream 100 bases:

>100_bases
GCGGCTCTAAAATTCGGAAGGAATGTCGGATATTCTATTTTTACCAACTATGTTAATTAGATGATTAGTGGTTGGTTCTG
ATCTAGAGTTTTACTGTTAT

Downstream 100 bases:

>100_bases
TCATTAACCTCAAGCTTGGATAGTTTTAAGTTATTCAGTCAGAACAAATAGGCCGCAAAGGGATTTCCTTCTGCGGCCTT
TTTTATAATCCTTTTAACAC

Product: DLP12 prophage; multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MFKLLVSMPPAMALIIAIISEVIATSFIPKTEQFTKLTPSLIVAVGYGIAFFLLSVTVKSMPVGIVYAIWSGAGIVLVAA
IGYFAYGQKLDLAGIIGISLILSGVLVVNLLSKTAGH

Sequences:

>Translated_117_residues
MFKLLVSMPPAMALIIAIISEVIATSFIPKTEQFTKLTPSLIVAVGYGIAFFLLSVTVKSMPVGIVYAIWSGAGIVLVAA
IGYFAYGQKLDLAGIIGISLILSGVLVVNLLSKTAGH
>Mature_117_residues
MFKLLVSMPPAMALIIAIISEVIATSFIPKTEQFTKLTPSLIVAVGYGIAFFLLSVTVKSMPVGIVYAIWSGAGIVLVAA
IGYFAYGQKLDLAGIIGISLILSGVLVVNLLSKTAGH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=46.3636363636364, Blast_Score=99, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12226; Mature: 12226

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKLLVSMPPAMALIIAIISEVIATSFIPKTEQFTKLTPSLIVAVGYGIAFFLLSVTVKS
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPVGIVYAIWSGAGIVLVAAIGYFAYGQKLDLAGIIGISLILSGVLVVNLLSKTAGH
CCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKLLVSMPPAMALIIAIISEVIATSFIPKTEQFTKLTPSLIVAVGYGIAFFLLSVTVKS
CCEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPVGIVYAIWSGAGIVLVAAIGYFAYGQKLDLAGIIGISLILSGVLVVNLLSKTAGH
CCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]