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The map label for this gene is ffh [H]

Identifier: 59711155

GI number: 59711155

Start: 596889

End: 598262

Strand: Direct

Name: ffh [H]

Synonym: VF_0548

Alternate gene names: 59711155

Gene position: 596889-598262 (Clockwise)

Preceding gene: 59711152

Following gene: 59711156

Centisome position: 20.6

GC content: 40.17

Gene sequence:

>1374_bases
ATGTTTGATAATTTAACGGATAGACTATCCAGAACACTGAAAAATATCAGTGGTAAAGGTCGATTAACAGAAGACAACAT
TAAAGAAACGCTACGTGAAGTACGTATGGCGTTACTGGAAGCTGATGTAGCTTTACCAGTGGTTCGTGATTTTGTAAAAC
GCGTAAAAGAAGGTGCTGTAGGTGTTGAAGTATCAAAAAGTTTAACACCTGGCCAAGAATTCATAAAAATTGTTCAAGCT
GAACTAGAAGCAGTTATGGGGGATTCTAACGAAGCCCTTAACCTAGCTTGTCAGCCGCCAGCGGTTATTTTAATGGCAGG
CTTACAAGGTGCAGGTAAAACAACAAGTACCGGTAAATTAGCTAAACTATTAAAAGAGCGCGACAAGAAAAAGGTATTAG
TAGTTTCTGCCGATGTTTATCGTCCTGCGGCGATCAAACAGTTAGAAACATTAGCAGCAGATGTGGATGTTGATTTCTTC
CCATCTAGTGCAGATCAAAAGCCTATTGATATTGTTGATGCGGCGATTAGCCACGCAAAACTGAAGTTTTTTGATGTTGT
TATTGTCGATACAGCAGGTCGTTTGGCTGTTGATACCGAAATGATGGATGAAATCAAACAGCTTCATGCTCATGTAAATC
CGATTGAGACTCTGTTTGTTGTTGATGCAATGACAGGTCAAGATGCGGCAAATACAGCAAAAGCGTTTGGTGATGCTTTA
CCTCTAACCGGTGTTATTTTAACAAAGGTTGATGGTGATGCTCGTGGTGGTGCTGCATTATCAGTTCGTCATATTACAGG
TAAACCAGTTAAATTCTTAGGTGTTGGTGAAAAAACTGACGCACTAGAACCGTTCCACCCAGAACGTATTGCTTCTCGAA
TTTTAGGTATGGGTGATGTTCTTTCTTTAATTGAAGATCTTGAAAAGAACGTAGATAAAGAAAAAGCAGAGAAACTGGCG
AAAAAATTCAAAGAGAAAAAAGGCTTTGATTTAGAAGATTTCCGTGAGCAGCTTGGTCAGATGAAAAACATGGGCGGCAT
GATGGGCATGATGGATAAACTTCCAGGAATGTCTCAGCTACCAAGTGATGTGAAAGATAAAGTTGATGATAAAATGTTCA
ATCAAATGGAAGCTATTATTAATTCCATGACGATGAAAGAGCGTCAACGTCCTGAAATCATCAAAGGTTCACGCAAAAAA
CGTATCGCTGCGGGTTCTGGTGTACAAGTTCAAGATGTAAACCGTATGCTAAAACAATTTACCCAAATGCAGAAGATGAT
GAAGAAAATGCAGAAGGGTGGCATGAAAGGCATGATGCGTAATATGCAAGGTATGATGGGTGGTATGGGCGGAATGGGTG
GCTTCGGTCGCTAA

Upstream 100 bases:

>100_bases
CAATCTCGGTAGGTGTGATTCAGTTAGGTTAAAAAATTTTCATTATTACGCCCAAGATTTAGGTATAATCGTTTAATGGT
CGCAAAGTAGGCGCAGGAAT

Downstream 100 bases:

>100_bases
AAATCCAATACAATCAGTAGTATCTAAAAAGATATATAATTAAGGGCGGCAAGTTAATTTGTTGAAAAACTTAACCTGGC
GCACTTTTTTAAACCAATTT

Product: Signal recognition particle (SRP) component with 4.5S RNA (ffs)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFDNLTDRLSRTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEFIKIVQA
ELEAVMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLETLAADVDVDFF
PSSADQKPIDIVDAAISHAKLKFFDVVIVDTAGRLAVDTEMMDEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPVKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPSDVKDKVDDKMFNQMEAIINSMTMKERQRPEIIKGSRKK
RIAAGSGVQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGFGR

Sequences:

>Translated_457_residues
MFDNLTDRLSRTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEFIKIVQA
ELEAVMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLETLAADVDVDFF
PSSADQKPIDIVDAAISHAKLKFFDVVIVDTAGRLAVDTEMMDEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPVKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPSDVKDKVDDKMFNQMEAIINSMTMKERQRPEIIKGSRKK
RIAAGSGVQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGFGR
>Mature_457_residues
MFDNLTDRLSRTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAVGVEVSKSLTPGQEFIKIVQA
ELEAVMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKLAKLLKERDKKKVLVVSADVYRPAAIKQLETLAADVDVDFF
PSSADQKPIDIVDAAISHAKLKFFDVVIVDTAGRLAVDTEMMDEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDAL
PLTGVILTKVDGDARGGAALSVRHITGKPVKFLGVGEKTDALEPFHPERIASRILGMGDVLSLIEDLEKNVDKEKAEKLA
KKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQLPSDVKDKVDDKMFNQMEAIINSMTMKERQRPEIIKGSRKK
RIAAGSGVQVQDVNRMLKQFTQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGFGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=443, Percent_Identity=31.3769751693002, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI226371618, Length=345, Percent_Identity=33.6231884057971, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=37.5, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI23308697, Length=320, Percent_Identity=25.625, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=25.9493670886076, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788963, Length=446, Percent_Identity=78.0269058295964, Blast_Score=685, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=34.6613545816733, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=29.5964125560538, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193206261, Length=202, Percent_Identity=34.1584158415842, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6325345, Length=442, Percent_Identity=32.579185520362, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=25.9615384615385, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647949, Length=454, Percent_Identity=29.5154185022026, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=28.6363636363636, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50017; Mature: 50017

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLTDRLSRTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVEVSKSLTPGQEFIKIVQAELEAVMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKL
CEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHEECCCCCCCCCCHHHH
AKLLKERDKKKVLVVSADVYRPAAIKQLETLAADVDVDFFPSSADQKPIDIVDAAISHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFFDVVIVDTAGRLAVDTEMMDEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDAL
HEEEEEEEEECCCCCEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRHITGKPVKFLGVGEKTDALEPFHPERIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLEKNVDKEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHCC
PSDVKDKVDDKMFNQMEAIINSMTMKERQRPEIIKGSRKKRIAAGSGVQVQDVNRMLKQF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHEEECCCCCCHHHHHHHHHHH
TQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MFDNLTDRLSRTLKNISGKGRLTEDNIKETLREVRMALLEADVALPVVRDFVKRVKEGAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GVEVSKSLTPGQEFIKIVQAELEAVMGDSNEALNLACQPPAVILMAGLQGAGKTTSTGKL
CEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHEECCCCCCCCCCHHHH
AKLLKERDKKKVLVVSADVYRPAAIKQLETLAADVDVDFFPSSADQKPIDIVDAAISHAK
HHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
LKFFDVVIVDTAGRLAVDTEMMDEIKQLHAHVNPIETLFVVDAMTGQDAANTAKAFGDAL
HEEEEEEEEECCCCCEECHHHHHHHHHHHHCCCHHHHHHEEECCCCCCHHHHHHHHHCCC
PLTGVILTKVDGDARGGAALSVRHITGKPVKFLGVGEKTDALEPFHPERIASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLEKNVDKEKAEKLAKKFKEKKGFDLEDFREQLGQMKNMGGMMGMMDKLPGMSQL
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCHHCC
PSDVKDKVDDKMFNQMEAIINSMTMKERQRPEIIKGSRKKRIAAGSGVQVQDVNRMLKQF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHEEECCCCCCHHHHHHHHHHH
TQMQKMMKKMQKGGMKGMMRNMQGMMGGMGGMGGFGR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]