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The map label for this gene is proC [H]

Identifier: 59711036

GI number: 59711036

Start: 457302

End: 458120

Strand: Reverse

Name: proC [H]

Synonym: VF_0429

Alternate gene names: 59711036

Gene position: 458120-457302 (Counterclockwise)

Preceding gene: 59711037

Following gene: 59711035

Centisome position: 15.81

GC content: 42.37

Gene sequence:

>819_bases
ATGGAACATCGCAATATTGCTTTTATTGGTGCAGGTAACATGACTCGCTCAATTATTGCGGGTCTAATTAGCAGTGGTTA
TCCAAAAGATAAAATCACGGCAACTAACCCTAGTACTGAAAAACTAGACCATTTATCTCAATGTTACGGTATCCACACCA
GCACAGATAACTTACAAGCTGCACAGCAAGCTGATGTGATTGTTCTCGCTGTAAAACCACAAATGATGGCAATGGCTGCA
GAGCCTCTACAGCAAATTGATTTTTCAAATAAGTTAGTGATTTCCATTGCTGCTGGTATTTCAGCAAAACGTTTAAATGA
AATGTTTGCTAGTGAACTCAATCTAGTTCGAGTAATGCCAAACACTCCTGCATTAGTAGGCAAAGGCATGAGTGGCTTAT
TTGCTGTTGAGCACATAAATGAACAAGATAAGTGCTTCGCAAGTGATTTACTTTCCGCGGTCGGTGAAGTGTGTTGGGTG
GCGCAAGAATCCGGAATAAACTCGGTAATTGCAGCGGCAGGAAGTGCGCCTGCGTATTTCTTTTTATTTATGGAAGCAAT
GCAAGCAGAAGCCATTAATCAGGGCTTTGATGAAGCAACTGCTCGTCAACTTGTACAACAAGCGGCTCTTGGTGCTGCTG
AAATGGTTGTCGCTAATCCAGAAACACAATTATCAACACTGCGTGAGCAAGTAACTTCAAAGGGTGGAACGACCGCAGAA
GCACTGCGCACGTTTAATGAACATCAACTGCAAGAGATCGTAGCAAAAGCAATGCAAGCTGCCGTTTCTCGCGCAGAAGA
AATGGAATCTTTATTTTAA

Upstream 100 bases:

>100_bases
ATAAAAACAAAGAATAATATCTGCTATCAATTTCAAGTAAAACAAATTGATATCATATGCTCACAACAACTAAGGTCTAT
TGACCCTAAAAGGAATAGAA

Downstream 100 bases:

>100_bases
GATTCATAAAGCTAACTAAATTCTGATATTTCTAAGGTTAAACATACTATGAATGCAATGAGCTTTTTAATCTCAACCGT
TTTTGATCTATACATCATGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKDKITATNPSTEKLDHLSQCYGIHTSTDNLQAAQQADVIVLAVKPQMMAMAA
EPLQQIDFSNKLVISIAAGISAKRLNEMFASELNLVRVMPNTPALVGKGMSGLFAVEHINEQDKCFASDLLSAVGEVCWV
AQESGINSVIAAAGSAPAYFFLFMEAMQAEAINQGFDEATARQLVQQAALGAAEMVVANPETQLSTLREQVTSKGGTTAE
ALRTFNEHQLQEIVAKAMQAAVSRAEEMESLF

Sequences:

>Translated_272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKDKITATNPSTEKLDHLSQCYGIHTSTDNLQAAQQADVIVLAVKPQMMAMAA
EPLQQIDFSNKLVISIAAGISAKRLNEMFASELNLVRVMPNTPALVGKGMSGLFAVEHINEQDKCFASDLLSAVGEVCWV
AQESGINSVIAAAGSAPAYFFLFMEAMQAEAINQGFDEATARQLVQQAALGAAEMVVANPETQLSTLREQVTSKGGTTAE
ALRTFNEHQLQEIVAKAMQAAVSRAEEMESLF
>Mature_272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKDKITATNPSTEKLDHLSQCYGIHTSTDNLQAAQQADVIVLAVKPQMMAMAA
EPLQQIDFSNKLVISIAAGISAKRLNEMFASELNLVRVMPNTPALVGKGMSGLFAVEHINEQDKCFASDLLSAVGEVCWV
AQESGINSVIAAAGSAPAYFFLFMEAMQAEAINQGFDEATARQLVQQAALGAAEMVVANPETQLSTLREQVTSKGGTTAE
ALRTFNEHQLQEIVAKAMQAAVSRAEEMESLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=27.8195488721804, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI24797095, Length=273, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI24797097, Length=273, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=28.2051282051282, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=34.5864661654135, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=32.2097378277154, Blast_Score=126, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=32.5, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=289, Percent_Identity=24.9134948096886, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=32.089552238806, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=30.3249097472924, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=31.7647058823529, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29125; Mature: 29125

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRNIAFIGAGNMTRSIIAGLISSGYPKDKITATNPSTEKLDHLSQCYGIHTSTDNLQA
CCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCHHHH
AQQADVIVLAVKPQMMAMAAEPLQQIDFSNKLVISIAAGISAKRLNEMFASELNLVRVMP
HHHCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEECC
NTPALVGKGMSGLFAVEHINEQDKCFASDLLSAVGEVCWVAQESGINSVIAAAGSAPAYF
CCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
FLFMEAMQAEAINQGFDEATARQLVQQAALGAAEMVVANPETQLSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHCCCCHHH
ALRTFNEHQLQEIVAKAMQAAVSRAEEMESLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHRNIAFIGAGNMTRSIIAGLISSGYPKDKITATNPSTEKLDHLSQCYGIHTSTDNLQA
CCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCHHHH
AQQADVIVLAVKPQMMAMAAEPLQQIDFSNKLVISIAAGISAKRLNEMFASELNLVRVMP
HHHCCEEEEEECHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHCCEEEECC
NTPALVGKGMSGLFAVEHINEQDKCFASDLLSAVGEVCWVAQESGINSVIAAAGSAPAYF
CCCHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHH
FLFMEAMQAEAINQGFDEATARQLVQQAALGAAEMVVANPETQLSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHCCCCHHH
ALRTFNEHQLQEIVAKAMQAAVSRAEEMESLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]