Click here to switch to the map view.

The map label for this gene is kdsC [H]

Identifier: 59710998

GI number: 59710998

Start: 424169

End: 424729

Strand: Reverse

Name: kdsC [H]

Synonym: VF_0391

Alternate gene names: 59710998

Gene position: 424729-424169 (Counterclockwise)

Preceding gene: 59710999

Following gene: 59710997

Centisome position: 14.66

GC content: 39.04

Gene sequence:

>561_bases
ATGACAACAAAATTAGTTTCAACTCTGTATGGCCAAGTTGAAGAGTCTATCTTTAACATAGCAAAAGAAATCAAGCTTCT
AATTTGTGATGTTGATGGCGTCTTCTCTGATGGCCTTGTTTATATGGGGAATGATGGCGAAGAACTAAAAACGTTCCATA
CTCGTGATGGCTACGGTGTGAAATCACTCATGTCAGCAGGGGTTGAAATTGCGATTATTACGGGTCGCAGCTCAAAAATT
GTTGAAAACCGAATGACGGCCCTTGGTATTAAATTGATCTACCAAGGACAAGACAACAAATTACAAGCATACCAAGATAT
TTTAACTAAACTCAATGTAGCTCCAGAGCATACTGGCTATATTGGTGATGACCTTATTGATTGGCCTGTTATGGAAAAAG
TTGCATTAAAGGTATGTGTTGCTGATGGACACCCTTTATTAGTTCAACGTGCAAACTATGTAACAACCATAAAAGGTGGT
CATGGTGCTGTTCGTGAAGTAAGCGACCTGATCCTAGAAGCAAAAGGTGAATTAGAGCAACATAAAGGTTTGAGCATATG
A

Upstream 100 bases:

>100_bases
TGCAAGATAAGAAAATAAATGGATTATTACTTTGTGATGAAACTCATCGTTTAGTTGGTGCATTGAATATGCATGACTTA
TTAAAAGCGGGAGTGATGTA

Downstream 100 bases:

>100_bases
GCTTAAAACATCTTTTCATGGCCGTTCTATTGATGATTTGTAGCTGGTCAGGCTACAACTTATATTATGACTACGTGAAA
GGTGAACAACAGACAACACC

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTTKLVSTLYGQVEESIFNIAKEIKLLICDVDGVFSDGLVYMGNDGEELKTFHTRDGYGVKSLMSAGVEIAIITGRSSKI
VENRMTALGIKLIYQGQDNKLQAYQDILTKLNVAPEHTGYIGDDLIDWPVMEKVALKVCVADGHPLLVQRANYVTTIKGG
HGAVREVSDLILEAKGELEQHKGLSI

Sequences:

>Translated_186_residues
MTTKLVSTLYGQVEESIFNIAKEIKLLICDVDGVFSDGLVYMGNDGEELKTFHTRDGYGVKSLMSAGVEIAIITGRSSKI
VENRMTALGIKLIYQGQDNKLQAYQDILTKLNVAPEHTGYIGDDLIDWPVMEKVALKVCVADGHPLLVQRANYVTTIKGG
HGAVREVSDLILEAKGELEQHKGLSI
>Mature_185_residues
TTKLVSTLYGQVEESIFNIAKEIKLLICDVDGVFSDGLVYMGNDGEELKTFHTRDGYGVKSLMSAGVEIAIITGRSSKIV
ENRMTALGIKLIYQGQDNKLQAYQDILTKLNVAPEHTGYIGDDLIDWPVMEKVALKVCVADGHPLLVQRANYVTTIKGGH
GAVREVSDLILEAKGELEQHKGLSI

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=154, Percent_Identity=25.974025974026, Blast_Score=74, Evalue=7e-14,
Organism=Escherichia coli, GI2367202, Length=181, Percent_Identity=60.2209944751381, Blast_Score=235, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 20365; Mature: 20234

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKLVSTLYGQVEESIFNIAKEIKLLICDVDGVFSDGLVYMGNDGEELKTFHTRDGYGV
CCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCHHHHEEECCCCCCH
KSLMSAGVEIAIITGRSSKIVENRMTALGIKLIYQGQDNKLQAYQDILTKLNVAPEHTGY
HHHHHCCCEEEEEECCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
IGDDLIDWPVMEKVALKVCVADGHPLLVQRANYVTTIKGGHGAVREVSDLILEAKGELEQ
CCCCHHCCHHHHHHHHHHEECCCCEEEEEECCEEEEEECCCCHHHHHHHHHHHCCCCHHH
HKGLSI
CCCCCC
>Mature Secondary Structure 
TTKLVSTLYGQVEESIFNIAKEIKLLICDVDGVFSDGLVYMGNDGEELKTFHTRDGYGV
CHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEECCCCHHHHEEECCCCCCH
KSLMSAGVEIAIITGRSSKIVENRMTALGIKLIYQGQDNKLQAYQDILTKLNVAPEHTGY
HHHHHCCCEEEEEECCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCC
IGDDLIDWPVMEKVALKVCVADGHPLLVQRANYVTTIKGGHGAVREVSDLILEAKGELEQ
CCCCHHCCHHHHHHHHHHEECCCCEEEEEECCEEEEEECCCCHHHHHHHHHHHCCCCHHH
HKGLSI
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]