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The map label for this gene is lptA [H]

Identifier: 59710996

GI number: 59710996

Start: 423131

End: 423628

Strand: Reverse

Name: lptA [H]

Synonym: VF_0389

Alternate gene names: 59710996

Gene position: 423628-423131 (Counterclockwise)

Preceding gene: 59710997

Following gene: 59710995

Centisome position: 14.62

GC content: 37.15

Gene sequence:

>498_bases
ATGAAGCTTTCACACGTTAGTCTACTTGCAAGTCTACTTTTTAGCGCTTCAAGCTGGGCATTGAGTAGCGATACAGAACA
ACCGATCCACATTAATTCAAATTCACAGAATTTTGATATGCAAAGTAATCAAGTAACCTTCACAGGTAACGTGACACTAA
AACAAGGCAGCATCGAAATTTTTGCAGATAAAATTGTGGTAATTCGTCCTCAAGGTAAAGAAGGACGAGAAGTGTTAGAA
GCATATGGAAAACCAACTCGCTTTAGCCAATTAACGGATGATGGCAAAACACTAAAGGGTAAAGCAAACAAATTGCGTTA
TGAGCTAGAAAACGAATTTCTAAAAATGACAGATAGCGCAGAGTTAACCCAAGATGACAGCATCATAAAAGGTAAAGTAA
TTACCTATAATATGAAGACTCAAAAACTGATTGCTGATGGTGGTAAAGACGATCGCGTAACAACCATCCTTCAGCCTAGC
CAATTGAATAATAAATAA

Upstream 100 bases:

>100_bases
GTTAATCTCATTGGCCCTACTTTTGAAACAACAGGAGTAGGAATGAAAGGTAACTTCACAAGCCAAGAAGCAACCCTATT
AGAAAATGTACAAGGTATCT

Downstream 100 bases:

>100_bases
TTATGGCCATATTAGAAGCAAAGAATTTAGCAAAAACATACGGAAGTCGAAAAGTAGTTTCCGATGTAAGTCTTACCGTT
GAATCTGGAAAAATTGTTGG

Product: ABC transporter periplasmic-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MKLSHVSLLASLLFSASSWALSSDTEQPIHINSNSQNFDMQSNQVTFTGNVTLKQGSIEIFADKIVVIRPQGKEGREVLE
AYGKPTRFSQLTDDGKTLKGKANKLRYELENEFLKMTDSAELTQDDSIIKGKVITYNMKTQKLIADGGKDDRVTTILQPS
QLNNK

Sequences:

>Translated_165_residues
MKLSHVSLLASLLFSASSWALSSDTEQPIHINSNSQNFDMQSNQVTFTGNVTLKQGSIEIFADKIVVIRPQGKEGREVLE
AYGKPTRFSQLTDDGKTLKGKANKLRYELENEFLKMTDSAELTQDDSIIKGKVITYNMKTQKLIADGGKDDRVTTILQPS
QLNNK
>Mature_165_residues
MKLSHVSLLASLLFSASSWALSSDTEQPIHINSNSQNFDMQSNQVTFTGNVTLKQGSIEIFADKIVVIRPQGKEGREVLE
AYGKPTRFSQLTDDGKTLKGKANKLRYELENEFLKMTDSAELTQDDSIIKGKVITYNMKTQKLIADGGKDDRVTTILQPS
QLNNK

Specific function: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain

COG id: COG1934

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptA family [H]

Homologues:

Organism=Escherichia coli, GI1789592, Length=166, Percent_Identity=52.4096385542169, Blast_Score=167, Evalue=3e-43,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014340
- InterPro:   IPR005653 [H]

Pfam domain/function: PF03968 OstA [H]

EC number: NA

Molecular weight: Translated: 18383; Mature: 18383

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSHVSLLASLLFSASSWALSSDTEQPIHINSNSQNFDMQSNQVTFTGNVTLKQGSIEI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEECCCEEE
FADKIVVIRPQGKEGREVLEAYGKPTRFSQLTDDGKTLKGKANKLRYELENEFLKMTDSA
EEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEECCCCHHEEEHCCHHHEECCCCC
ELTQDDSIIKGKVITYNMKTQKLIADGGKDDRVTTILQPSQLNNK
CCCCCCCEEECEEEEEECCHHEEEECCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKLSHVSLLASLLFSASSWALSSDTEQPIHINSNSQNFDMQSNQVTFTGNVTLKQGSIEI
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEECCCEEE
FADKIVVIRPQGKEGREVLEAYGKPTRFSQLTDDGKTLKGKANKLRYELENEFLKMTDSA
EEEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEECCCCHHEEEHCCHHHEECCCCC
ELTQDDSIIKGKVITYNMKTQKLIADGGKDDRVTTILQPSQLNNK
CCCCCCCEEECEEEEEECCHHEEEECCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]