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The map label for this gene is pgi [H]

Identifier: 59710911

GI number: 59710911

Start: 313389

End: 315041

Strand: Direct

Name: pgi [H]

Synonym: VF_0304

Alternate gene names: 59710911

Gene position: 313389-315041 (Clockwise)

Preceding gene: 59710910

Following gene: 59710914

Centisome position: 10.82

GC content: 40.35

Gene sequence:

>1653_bases
ATGTTAAAAAACATCAACCCAACAGAAACTCAAGCTTGGGCAGACTTAACAGCGCACTTTGAAACAGCACAAGATTTTAA
TTTATCAGATTTATTTGCTGCTGATGCACAACGTTTCGATAAGTTTTCAGCAACGTTTGGCCAAGATATTTTAGTCGATT
TTTCTAAAAACTTAATTACTGAAGAAACAATGAAGAAGTTGTTTGCACTTGCTGAGCAAACAGAATTATCTTCAGCAATT
ACAGCGATGTTCAGTGGTGAAAAAATCAATAAAACTGAAGGTCGTTCAGTGCTTCATACTGCACTTCGTAACCGTAGCAA
CACACCAGTGATGGTTGATGGTGAAGATGTAATGCCTGCAGTAAATGCAGTATTAGAAAAAATGAAAGGCTTCACAGAGC
GTCTAATTTCTGGTGAGTGGAAAGGTTACACAGGCAAAGAAATTACGGATATCGTAAATATCGGTATCGGCGGTTCAGAC
CTTGGTCCATACATGGTATCTGAAGCTCTAGCACCATACAAAACGCGTCTAAATATGCACTTTGTTTCTAACGTAGATGG
TACGCACATTGTTGAAACACTGAAGCCGCTAAACCCAGAGACGACATTATTCTTAATCGCCTCTAAGACGTTCACAACTC
AAGAAACAATGACGAACGCACACAGCGCTCGTGATTGGTTCCTTGCTGAAGCTGGTGATCAAGCACACGTTGCTAAACAC
TTCGCGGCACTATCAACAAACGCACAGTCTGTATCTGAGTTTGGTATTGATACTGACAATATGTTTGAATTCTGGGATTG
GGTTGGTGGTCGTTACTCACTATGGTCTGCTATCGGTCTTTCTATCGCATTAGCGGTTGGTTTTGATAACTTTATTGAGT
TGTTAGAAGGTGCTCATGAAGTAGATAAGCACTTCGCTGAAACCGATCTTGAAAATAACGTACCTGTTATCTTAGCGCTA
ATTGGCTTATGGTATAACAACTTCCACGGTGCTGAATCTGAATCTATTCTTCCATACGACCAATACTTACACCGTTTTGC
TGCGTACTTCCAACAAGGCAACATGGAGTCAAATGGTAAGTGTGTTGATCGTAATGGTAACCCTGTTGATTACCAAACAG
GTCCAATTATTTGGGGTGAACCTGGTACAAATGGCCAACATGCGTTCTACCAATTAATTCACCAAGGTACAAAACTTATC
CCTTGTGATTTTATTGCTCCAGCAATCAGCCACAACCAAGTAGGCGATCATCATCAAAAACTGATGTCTAACTTCTTCGC
ACAAACTGAAGCGTTAGCGTTTGGTAAAACAGAAGAGACAGTGAAAGCAGAATTTGCTGCTGCAGGTAAAACAGAAGCTG
AAGTCGCTGAGCTTGTACCATTTAAAGTATTTGAAGGTAACCGTCCAACGAACTCAATTCTTGTTAAACAAGTTACTCCT
AAAACACTAGGTAACCTTATCGCAATGTACGAACACAAAATTTTCGTTCAAGGTGTGATTTGGAATATTTTCAGCTTCGA
CCAATGGGGCGTAGAGCTTGGTAAGCAACTGGCTAACCAAATTCTTCCTGAGTTAGCTGATGATAAAGCGGTAACGTCTC
ACGACAGTTCAACAAACGGTTTAATTAACGCATTTAAAGCGTTTCAAGCTTAA

Upstream 100 bases:

>100_bases
TCATAATAAATAAAGTTCACCAATTTTTAGATTCGTATAAACGGGGAGTTCTTAGCTACGACTTGGAACTTACAAGCATA
TTACACAGGATATTTTTACC

Downstream 100 bases:

>100_bases
TCATTAGCTTATTGCGTTAACTAATTAAAAAGAGCTGACTTCGGTCGGCTCTTTTTTTAGATATTACAGGCAATAAAAAA
GGTTGATACCTAAATATCAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLITEETMKKLFALAEQTELSSAI
TAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPAVNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHEVDKHFAETDLENNVPVILAL
IGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNGLINAFKAFQA

Sequences:

>Translated_550_residues
MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLITEETMKKLFALAEQTELSSAI
TAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPAVNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHEVDKHFAETDLENNVPVILAL
IGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNGLINAFKAFQA
>Mature_550_residues
MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLITEETMKKLFALAEQTELSSAI
TAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPAVNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHEVDKHFAETDLENNVPVILAL
IGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNGLINAFKAFQA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=532, Percent_Identity=64.4736842105263, Blast_Score=717, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=532, Percent_Identity=60.3383458646617, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=75.7741347905282, Blast_Score=897, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=62.5454545454545, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=62.9357798165138, Blast_Score=706, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=58.3180987202925, Blast_Score=643, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=543, Percent_Identity=62.7992633517495, Blast_Score=702, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=543, Percent_Identity=62.7992633517495, Blast_Score=702, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=543, Percent_Identity=62.7992633517495, Blast_Score=702, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 60931; Mature: 60931

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLIT
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EETMKKLFALAEQTELSSAITAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHH
VNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSDLGPYMVSEALAPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCHHHHHHH
FAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VDKHFAETDLENNVPVILALIGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGK
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
CVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNQVGDHHQK
EECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHH
LMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCEEEEECCH
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
LINAFKAFQA
HHHHHHHHCC
>Mature Secondary Structure
MLKNINPTETQAWADLTAHFETAQDFNLSDLFAADAQRFDKFSATFGQDILVDFSKNLIT
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EETMKKLFALAEQTELSSAITAMFSGEKINKTEGRSVLHTALRNRSNTPVMVDGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHHH
VNAVLEKMKGFTERLISGEWKGYTGKEITDIVNIGIGGSDLGPYMVSEALAPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCHHHHHHH
FAALSTNAQSVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFIELLEGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VDKHFAETDLENNVPVILALIGLWYNNFHGAESESILPYDQYLHRFAAYFQQGNMESNGK
HHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
CVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNQVGDHHQK
EECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHH
LMSNFFAQTEALAFGKTEETVKAEFAAAGKTEAEVAELVPFKVFEGNRPTNSILVKQVTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEECCCCCCCCEEEEECCH
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAVTSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
LINAFKAFQA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA