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The map label for this gene is hemX [H]

Identifier: 59710671

GI number: 59710671

Start: 71808

End: 72980

Strand: Reverse

Name: hemX [H]

Synonym: VF_0064

Alternate gene names: 59710671

Gene position: 72980-71808 (Counterclockwise)

Preceding gene: 59710672

Following gene: 59710670

Centisome position: 2.52

GC content: 41.18

Gene sequence:

>1173_bases
ATGACAAAAAATAATAATACAACACAGCCAACCGAAGATAAGCCGGTTGTGACTACAGCCCCTGATATAAAAAAAGAGCC
AGAGAAAACCACCACACACTCTGCTTCTAACACTGAAAATATTGTCGATAAAAAAGGCCGTCGCTTAGGGACTGTTGCCA
TTATTATCTCTATTTTATTCAGTGGCGGTGCCTTCTTAGCTTCGCAACAACAAGTTACCCAACAACAAATCCAAATCGCT
CAACTTGAGCAAAAATTAAAAACAGCAGATACCACGCTTGATGCAAAACTGGTTGCAGCAGAGCAGCGCATTACCGATAA
AGCAGATGAGATTGTACGTAAGGCGACGGTTCTAATGCAGCAACAAGATAAGAGCATTGCTAGCCTTCAATTGGCGATTG
CTGATATCAAAGGTCGTCGTCCAAATGACTGGTTACTTGCAGAAGCGGATTACTTAGTAAAAATGGCTGGTCGTAAATTA
TGGTTGGAACATGATGTGGTCAGTGCAACGCGTTTAATGGAAAACGCAGACCAACGAATTTCTGCATTAAACGATCCAAG
CCTTACACCGCTACGTCGCGCAATGGCTGATGACATTGCGACATTAAAAGCGATCCCATTAATTGACCGTGATGGCTTAG
TATTAAAACTAAATAGCCTAGAACAACAAATTAATAAACTGCCATTGGCAAGCGCCGTTCTTCCAGAAGCTGATGCTGTC
GAAGAAAAACACGTTTCAACCAACATTAATGATTGGCAATCAAACCTAAAACAATCTCTTAATGATTTTGCTGGCCACTT
CATTACATATCGAGTTCGTGAAGGTAACGTTATTCCACTACTTAGCCCTGAGCAGCATTTTTACTTAAAAGAGAACATTA
AAGGCAAATTGCTACTGGCATCTAAAGCACTTTATCGTGAGCAAAGTGAGGTTTATGCAACATCACTAGAAAGCGCAAAA
CTGTGGTCTTCTCAGTACTTCCAACAAGATGATCCTGCAGTGAAAAGCTTTATGGCTCAGCTAGACTCTTTAGCAAAATA
CAAAGTAGACGTTCGTTATCCAAAGAAAATGAAGACTCAAGCGCTATTGTCGGACTTCATTTCAGAGCGACTTCGCCGTA
ATGTTCAAGCGATTGGTGACACCCCAAAAGCAACTGAAGGAGGTAAATCATGA

Upstream 100 bases:

>100_bases
CAAAAGAACTTGGTTATCAACATATTGAAACGGTTGGCGGAGCCTCTAATTCCGACTTGCTGCACTATATCAGTGAGCAT
CATTATGATGGGATTTTCAA

Downstream 100 bases:

>100_bases
TCCGATTACTTCTTCTGGCGATTGTCTTAGTCGGTGGATTAATCGTGGGAACGACCTTTGCTGATCAACAAGGCTATGTA
TTGATATCCGTTGCTAATAC

Product: uroporphyrinogen III methylase

Products: NA

Alternate protein names: Urogen-III methylase; ORF X [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTKNNNTTQPTEDKPVVTTAPDIKKEPEKTTTHSASNTENIVDKKGRRLGTVAIIISILFSGGAFLASQQQVTQQQIQIA
QLEQKLKTADTTLDAKLVAAEQRITDKADEIVRKATVLMQQQDKSIASLQLAIADIKGRRPNDWLLAEADYLVKMAGRKL
WLEHDVVSATRLMENADQRISALNDPSLTPLRRAMADDIATLKAIPLIDRDGLVLKLNSLEQQINKLPLASAVLPEADAV
EEKHVSTNINDWQSNLKQSLNDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEVYATSLESAK
LWSSQYFQQDDPAVKSFMAQLDSLAKYKVDVRYPKKMKTQALLSDFISERLRRNVQAIGDTPKATEGGKS

Sequences:

>Translated_390_residues
MTKNNNTTQPTEDKPVVTTAPDIKKEPEKTTTHSASNTENIVDKKGRRLGTVAIIISILFSGGAFLASQQQVTQQQIQIA
QLEQKLKTADTTLDAKLVAAEQRITDKADEIVRKATVLMQQQDKSIASLQLAIADIKGRRPNDWLLAEADYLVKMAGRKL
WLEHDVVSATRLMENADQRISALNDPSLTPLRRAMADDIATLKAIPLIDRDGLVLKLNSLEQQINKLPLASAVLPEADAV
EEKHVSTNINDWQSNLKQSLNDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEVYATSLESAK
LWSSQYFQQDDPAVKSFMAQLDSLAKYKVDVRYPKKMKTQALLSDFISERLRRNVQAIGDTPKATEGGKS
>Mature_389_residues
TKNNNTTQPTEDKPVVTTAPDIKKEPEKTTTHSASNTENIVDKKGRRLGTVAIIISILFSGGAFLASQQQVTQQQIQIAQ
LEQKLKTADTTLDAKLVAAEQRITDKADEIVRKATVLMQQQDKSIASLQLAIADIKGRRPNDWLLAEADYLVKMAGRKLW
LEHDVVSATRLMENADQRISALNDPSLTPLRRAMADDIATLKAIPLIDRDGLVLKLNSLEQQINKLPLASAVLPEADAVE
EKHVSTNINDWQSNLKQSLNDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLASKALYREQSEVYATSLESAKL
WSSQYFQQDDPAVKSFMAQLDSLAKYKVDVRYPKKMKTQALLSDFISERLRRNVQAIGDTPKATEGGKS

Specific function: Siroheme and cobalamin biosynthesis. [C]

COG id: COG2959

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790235, Length=252, Percent_Identity=40.4761904761905, Blast_Score=208, Evalue=5e-55,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007470 [H]

Pfam domain/function: PF04375 HemX [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 43548; Mature: 43417

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNNNTTQPTEDKPVVTTAPDIKKEPEKTTTHSASNTENIVDKKGRRLGTVAIIISILF
CCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
SGGAFLASQQQVTQQQIQIAQLEQKLKTADTTLDAKLVAAEQRITDKADEIVRKATVLMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDKSIASLQLAIADIKGRRPNDWLLAEADYLVKMAGRKLWLEHDVVSATRLMENADQRI
HHCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SALNDPSLTPLRRAMADDIATLKAIPLIDRDGLVLKLNSLEQQINKLPLASAVLPEADAV
HHCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCEEEEHHHHHHHHHCCCHHHHCCCHHHH
EEKHVSTNINDWQSNLKQSLNDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLA
HHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEEECCCCCCEEEEH
SKALYREQSEVYATSLESAKLWSSQYFQQDDPAVKSFMAQLDSLAKYKVDVRYPKKMKTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHH
ALLSDFISERLRRNVQAIGDTPKATEGGKS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TKNNNTTQPTEDKPVVTTAPDIKKEPEKTTTHSASNTENIVDKKGRRLGTVAIIISILF
CCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
SGGAFLASQQQVTQQQIQIAQLEQKLKTADTTLDAKLVAAEQRITDKADEIVRKATVLMQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQDKSIASLQLAIADIKGRRPNDWLLAEADYLVKMAGRKLWLEHDVVSATRLMENADQRI
HHCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SALNDPSLTPLRRAMADDIATLKAIPLIDRDGLVLKLNSLEQQINKLPLASAVLPEADAV
HHCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCEEEEHHHHHHHHHCCCHHHHCCCHHHH
EEKHVSTNINDWQSNLKQSLNDFAGHFITYRVREGNVIPLLSPEQHFYLKENIKGKLLLA
HHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCEEECCCCCCEEEEH
SKALYREQSEVYATSLESAKLWSSQYFQQDDPAVKSFMAQLDSLAKYKVDVRYPKKMKTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEECCCHHHHHH
ALLSDFISERLRRNVQAIGDTPKATEGGKS
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062586; 3054815; 1379743; 9278503; 9298646 [H]