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The map label for this gene is hemY [H]

Identifier: 59710670

GI number: 59710670

Start: 70627

End: 71811

Strand: Reverse

Name: hemY [H]

Synonym: VF_0063

Alternate gene names: 59710670

Gene position: 71811-70627 (Counterclockwise)

Preceding gene: 59710671

Following gene: 172087635

Centisome position: 2.48

GC content: 40.68

Gene sequence:

>1185_bases
ATGATCCGATTACTTCTTCTGGCGATTGTCTTAGTCGGTGGATTAATCGTGGGAACGACCTTTGCTGATCAACAAGGCTA
TGTATTGATATCCGTTGCTAATACGACCATAGAGATGAGCTTAACGACCTTAGTGCTCTTTATTGGTGCTTTGATTGCTG
GCTTGTTCTTACTTGAAATGATCGTGAAGCGTATTCTATCTGTGAGTAATTATACTCGTGGTTGGTTTAGTGCTCGTCAT
TTGCGTAAAGCTCGTTACAACACCTTTAAAGGTATGATTAAACTGCACGAAGGTGAATGGAAAGAAGCTGAGCGTCTAAT
TACTAAAGGTGGGCGTCATAATGATTTCCCACTATTAAATTATTTAGCTGCTGCAGAAGCTGCTCAAGGCCGTCAGCAAA
TTGATCTGAGAGATAAATACCTACAGCTAGCATCTGAACAAGATGACAGCACATTAGCGGTTGCATTAACCAGCGCTAAA
CTGCAAATGCGCCAAAAACAGTATGAACTGGCATTAGCGACCTTACAGTTTGTTAAGGTTGATTACCCTCGTAATCCGGT
TTTATTAGAACTACTAAAAGAGTGTTACCTTGCATTAAATGAATGGCAGGCTCTAAAAAATATCATTCATCCATTAAGTA
AAGCTAACCTAATTACGGACCAACAAGCCTTAGAGTTAGAAGAAAAAGCAGAATGTGGATTAATGGCCGTAATTGCGACC
AATAAAGGTACCGCTGGTTTACTAGAACATTGGGATGCCTTACCAAAGAAACTTAAAAAGCATGTTCCAATTCTGATTTG
TCTTATCCAACAATTACAAGCACGCAAAGCAGATTCAGAAGCGTACATTATCTTACGAGATAACTTAAAGAAACGAGCAG
ATGATCGTCTCGTTGCGCTACTGCCTACACTAAATCTTGCTGATTATCATCCAGTAACCGTGTTGCTTGAAAGCATGGCA
GATTACGATGTTCGCAACCCAGTAATTCAAAGTACGTTGGCACAGCTTTATATGCGAACACAAAAATGGCAGCCTGCACG
TGAACATTTTGAGGCTGCATTAGCGATTCGTGAAGATATGTCTGATTACGCCTATCTTGCGCGAGTATTAGATAAGCAAA
ACCGCAAACAAGCGGCGGCAGATCTTTCTCGTAAAGCACTGACTATGGTTGATGATAAAGGCTAA

Upstream 100 bases:

>100_bases
TGAAGACTCAAGCGCTATTGTCGGACTTCATTTCAGAGCGACTTCGCCGTAATGTTCAAGCGATTGGTGACACCCCAAAA
GCAACTGAAGGAGGTAAATC

Downstream 100 bases:

>100_bases
TTCGTTTTTATAACATCCATAAAAAATGCCACTCATTATTGAGTGGCATTTTTATTGATATTTGTTAGAAAGCTCGACTA
AATAAATGCGAATGCATCAC

Product: protoheme IX synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MIRLLLLAIVLVGGLIVGTTFADQQGYVLISVANTTIEMSLTTLVLFIGALIAGLFLLEMIVKRILSVSNYTRGWFSARH
LRKARYNTFKGMIKLHEGEWKEAERLITKGGRHNDFPLLNYLAAAEAAQGRQQIDLRDKYLQLASEQDDSTLAVALTSAK
LQMRQKQYELALATLQFVKVDYPRNPVLLELLKECYLALNEWQALKNIIHPLSKANLITDQQALELEEKAECGLMAVIAT
NKGTAGLLEHWDALPKKLKKHVPILICLIQQLQARKADSEAYIILRDNLKKRADDRLVALLPTLNLADYHPVTVLLESMA
DYDVRNPVIQSTLAQLYMRTQKWQPAREHFEAALAIREDMSDYAYLARVLDKQNRKQAAADLSRKALTMVDDKG

Sequences:

>Translated_394_residues
MIRLLLLAIVLVGGLIVGTTFADQQGYVLISVANTTIEMSLTTLVLFIGALIAGLFLLEMIVKRILSVSNYTRGWFSARH
LRKARYNTFKGMIKLHEGEWKEAERLITKGGRHNDFPLLNYLAAAEAAQGRQQIDLRDKYLQLASEQDDSTLAVALTSAK
LQMRQKQYELALATLQFVKVDYPRNPVLLELLKECYLALNEWQALKNIIHPLSKANLITDQQALELEEKAECGLMAVIAT
NKGTAGLLEHWDALPKKLKKHVPILICLIQQLQARKADSEAYIILRDNLKKRADDRLVALLPTLNLADYHPVTVLLESMA
DYDVRNPVIQSTLAQLYMRTQKWQPAREHFEAALAIREDMSDYAYLARVLDKQNRKQAAADLSRKALTMVDDKG
>Mature_394_residues
MIRLLLLAIVLVGGLIVGTTFADQQGYVLISVANTTIEMSLTTLVLFIGALIAGLFLLEMIVKRILSVSNYTRGWFSARH
LRKARYNTFKGMIKLHEGEWKEAERLITKGGRHNDFPLLNYLAAAEAAQGRQQIDLRDKYLQLASEQDDSTLAVALTSAK
LQMRQKQYELALATLQFVKVDYPRNPVLLELLKECYLALNEWQALKNIIHPLSKANLITDQQALELEEKAECGLMAVIAT
NKGTAGLLEHWDALPKKLKKHVPILICLIQQLQARKADSEAYIILRDNLKKRADDRLVALLPTLNLADYHPVTVLLESMA
DYDVRNPVIQSTLAQLYMRTQKWQPAREHFEAALAIREDMSDYAYLARVLDKQNRKQAAADLSRKALTMVDDKG

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=384, Percent_Identity=33.0729166666667, Blast_Score=203, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 44535; Mature: 44535

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLLLLAIVLVGGLIVGTTFADQQGYVLISVANTTIEMSLTTLVLFIGALIAGLFLLEM
CHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IVKRILSVSNYTRGWFSARHLRKARYNTFKGMIKLHEGEWKEAERLITKGGRHNDFPLLN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCCHHHH
YLAAAEAAQGRQQIDLRDKYLQLASEQDDSTLAVALTSAKLQMRQKQYELALATLQFVKV
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHEE
DYPRNPVLLELLKECYLALNEWQALKNIIHPLSKANLITDQQALELEEKAECGLMAVIAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEC
NKGTAGLLEHWDALPKKLKKHVPILICLIQQLQARKADSEAYIILRDNLKKRADDRLVAL
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCEEEE
LPTLNLADYHPVTVLLESMADYDVRNPVIQSTLAQLYMRTQKWQPAREHFEAALAIREDM
ECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SDYAYLARVLDKQNRKQAAADLSRKALTMVDDKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIRLLLLAIVLVGGLIVGTTFADQQGYVLISVANTTIEMSLTTLVLFIGALIAGLFLLEM
CHHHHHHHHHHHHHHHHCCEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
IVKRILSVSNYTRGWFSARHLRKARYNTFKGMIKLHEGEWKEAERLITKGGRHNDFPLLN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHCCCCCCCCHHHH
YLAAAEAAQGRQQIDLRDKYLQLASEQDDSTLAVALTSAKLQMRQKQYELALATLQFVKV
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHEE
DYPRNPVLLELLKECYLALNEWQALKNIIHPLSKANLITDQQALELEEKAECGLMAVIAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEEC
NKGTAGLLEHWDALPKKLKKHVPILICLIQQLQARKADSEAYIILRDNLKKRADDRLVAL
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCCCEEEE
LPTLNLADYHPVTVLLESMADYDVRNPVIQSTLAQLYMRTQKWQPAREHFEAALAIREDM
ECCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
SDYAYLARVLDKQNRKQAAADLSRKALTMVDDKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]