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The map label for this gene is acs [H]

Identifier: 172087770

GI number: 172087770

Start: 2672512

End: 2674461

Strand: Direct

Name: acs [H]

Synonym: VF_2383

Alternate gene names: 172087770

Gene position: 2672512-2674461 (Clockwise)

Preceding gene: 59712989

Following gene: 59712992

Centisome position: 92.23

GC content: 43.74

Gene sequence:

>1950_bases
ATGAGTGAGATTCACGTGTACCCGGTCAATCAAGATATCGCTAATAATGCACACGCTGATGATGATAAATATCGTGAAAT
GTACCAGCAATCCGTTATCAACCCTGAAGGATTTTGGCGTGAGCATGGACAAATTGTTGATTGGATGACTCCTTACACCA
AAGTTAAAAACACCTCTTTTGATACGGGTCATGTTGATATTAAGTGGTTTGAAGATGGTGAACTTAATGTATCGGCAAAC
TGTATTGATCGTCATTTAGCCACCCGAGGTAATGACGTTGCCATTATTTGGGAAGGCGATGACCCACAAGACGATGCCTC
TATTACCTTTAATGAACTGCATGAGCAAGTTTGTAAATTCTCTAATACACTAAAAAGCCAAGGCGTTCGTAAAGGCGATG
TGGTTTGTATTTATATGCCAATGGTGGCAGAAGCGGCTGTTGCGATGCTGGCTTGTACTCGCATCGGCGCTGTTCATACC
GTGGTATTTGGTGGTTTCTCACCAGAAGCTCTCGCAGGTCGAATCATTGATTCGGATGCAAAAGTCGTGATTACTGCGGA
TGAAGGCGTTCGCGGCGGACGTACCGTTCCACTGAAAAAGAATGTTGATGATGCACTGAATAATCCAGACGTAACCACCA
TTGAAAAAGTCGTGGTATTTCAACGTACAGGTAATGACATTGAATGGTCTGAAGGACGTGATGTTTGGTGGCACGAAGCA
ACGGCTGTTGCCTCCCCACATTGTGAACCAGAAGCAATGAATGCCGAAGACCCTCTATTTATCCTTTATACCTCAGGCTC
AACAGGAAAACCTAAAGGTGTACTTCATACCACTGGCGGCTACCTTGTCTATGCAGCCATAACCTTTAAATATATTTTCG
ATTATCAAGAAGGTGAAGTGTTCTGGTGTACTGCGGATGTTGGTTGGATCACAGGTCATACTTACTTAATTTATGGCCCT
CTTGCTAATGGAGCTAAAACCATCTTGTTTGAAGGAGTACCGAATTACCCAAGCACGAGCCGCATGAGTGAAGTGGTAGA
TAAACATAATGTTAATATTCTATACACAGCACCAACAGCCATCAGAGCACTTATGGCTCAAGGCACTGAAGCGGTTCAAG
GTACATCGCGCAGCTCACTACGAGTCATGGGCTCGGTAGGTGAACCAATCAACCCTGAAGCATGGGAATGGTATTACAAC
ACAATTGGTGATGCCCGTTGCCCTATTGTTGATACATGGTGGCAAACAGAAACGGGAGGCATTTTAATTTCCCCTCTTCC
TGGTGCAACAGCATTAAAACCAGGATCAGCGACTCGTCCATTCTTTGGTGTTCAACCCGCTTTAGTGGATAATATGGGTA
ATATTATTGAAGGAGCTACTGACGGGAACCTTGTCATTACCGACTCTTGGCCGGGACAAATGCGAACCATTTATGGTGAC
CATGACCGCTTTGAACAAACTTACTTTTCTACCTTTAAAGGCATGTATTTTACCAGTGACGGCGCTCGACGAGATGAAGA
TGGTTATTACTGGATCACTGGACGTGTTGATGACGTATTAAACGTATCAGGCCACCGCATGGGAACAGCCGAAGTTGAAT
CTGCATTAGTGGCGTTTGATAAAATTGCTGAAGCTGCAATTGTTGGCGTACCACATGATATTAAAGGCCAAGCGATTTAT
GCCTATATCACCCTAAATTCAGGCGAAATTCCAAGCGCAGAGCTACATAAAGAAGTCAAAGACTGGGTTAGAAAAGAAAT
TGGACCGATTGCTACTCCTGACTTTTTACATTGGACTGATTCATTACCTAAAACCCGTTCAGGCAAAATTATGCGTCGAA
TCCTTCGTAAAATAGCGACAGGAGATACCTCTAATCTAGGAGATACCTCGACACTAGCTGATCCAAGTGTGGTTGATAAG
CTGATCGAAGAACAAAGAAAGATAGCTTAA

Upstream 100 bases:

>100_bases
ATCAACCTTACAAATAAAAAAGCAGTACCAATGACGGTGCTGTACTGAAATCCAATAATAAATAAATCTGGATATTTGCT
GTATTCACAAGGAGAACAAC

Downstream 100 bases:

>100_bases
CCAAATATAAGCGTTCTAAAACATAACATTAACGCGTAAATTTTAATTAAAAGTCATCATAGATTTTCTGTGATGACTTT
TTTGATGTGACGTTTAGCTC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSAN
CIDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKFSNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHT
VVFGGFSPEALAGRIIDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEA
TAVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEVFWCTADVGWITGHTYLIYGP
LANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYN
TIGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFDKIAEAAIVGVPHDIKGQAIY
AYITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDK
LIEEQRKIA

Sequences:

>Translated_649_residues
MSEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSAN
CIDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKFSNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHT
VVFGGFSPEALAGRIIDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEA
TAVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEVFWCTADVGWITGHTYLIYGP
LANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYN
TIGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFDKIAEAAIVGVPHDIKGQAIY
AYITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDK
LIEEQRKIA
>Mature_648_residues
SEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSFDTGHVDIKWFEDGELNVSANC
IDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKFSNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHTV
VFGGFSPEALAGRIIDSDAKVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEAT
AVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEVFWCTADVGWITGHTYLIYGPL
ANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTAIRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYNT
IGDARCPIVDTWWQTETGGILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGDH
DRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFDKIAEAAIVGVPHDIKGQAIYA
YITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTDSLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKL
IEEQRKIA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=664, Percent_Identity=51.6566265060241, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=678, Percent_Identity=51.0324483775811, Blast_Score=693, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=50.7154213036566, Blast_Score=646, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=645, Percent_Identity=36.5891472868217, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI31982927, Length=635, Percent_Identity=24.4094488188976, Blast_Score=185, Evalue=2e-46,
Organism=Homo sapiens, GI42544132, Length=544, Percent_Identity=27.9411764705882, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI38505220, Length=519, Percent_Identity=30.0578034682081, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI115511026, Length=543, Percent_Identity=27.4401473296501, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI122937307, Length=525, Percent_Identity=25.9047619047619, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=25.968992248062, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=25.1937984496124, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=25.1937984496124, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI187761345, Length=389, Percent_Identity=25.4498714652956, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI187761343, Length=389, Percent_Identity=25.4498714652956, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI195947378, Length=438, Percent_Identity=25.3424657534247, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI42544134, Length=362, Percent_Identity=24.8618784530387, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI156151445, Length=549, Percent_Identity=22.4043715846995, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1790505, Length=649, Percent_Identity=72.5731895223421, Blast_Score=1026, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=636, Percent_Identity=35.6918238993711, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788107, Length=564, Percent_Identity=22.8723404255319, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI221142682, Length=515, Percent_Identity=22.3300970873786, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI145693145, Length=125, Percent_Identity=33.6, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=645, Percent_Identity=50.2325581395349, Blast_Score=644, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=634, Percent_Identity=50.788643533123, Blast_Score=643, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=649, Percent_Identity=21.4175654853621, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=574, Percent_Identity=24.0418118466899, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=520, Percent_Identity=21.7307692307692, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=515, Percent_Identity=22.1359223300971, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557194, Length=552, Percent_Identity=21.195652173913, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=31.3868613138686, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=639, Percent_Identity=48.0438184663537, Blast_Score=628, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=636, Percent_Identity=46.3836477987421, Blast_Score=578, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319699, Length=382, Percent_Identity=23.2984293193717, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667955, Length=661, Percent_Identity=52.3449319213313, Blast_Score=699, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=559, Percent_Identity=56.350626118068, Blast_Score=649, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=517, Percent_Identity=56.8665377176016, Blast_Score=606, Evalue=1e-173,
Organism=Drosophila melanogaster, GI21355225, Length=647, Percent_Identity=34.4667697063369, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI18859661, Length=545, Percent_Identity=25.1376146788991, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24656500, Length=531, Percent_Identity=23.9171374764595, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573631, Length=564, Percent_Identity=21.4539007092199, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20130353, Length=564, Percent_Identity=21.4539007092199, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=22.1579961464355, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24581924, Length=524, Percent_Identity=20.8015267175573, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71682; Mature: 71551

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSF
CCCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCCHHHCCCCC
DTGHVDIKWFEDGELNVSANCIDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKF
CCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHH
SNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHTVVFGGFSPEALAGRIIDSDA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEA
EEEEECCCCCCCCEEECCCCCHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECH
TAVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEV
HCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHEEEEEEEEEECCCCE
FWCTADVGWITGHTYLIYGPLANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTA
EEEECCCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHH
IRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYNTIGDARCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEECCCCCCEEEEECC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFD
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGVPHDIKGQAIYAYITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKLIEEQRKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEIHVYPVNQDIANNAHADDDKYREMYQQSVINPEGFWREHGQIVDWMTPYTKVKNTSF
CCEEEEECCHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCEEECCCCCHHHCCCCC
DTGHVDIKWFEDGELNVSANCIDRHLATRGNDVAIIWEGDDPQDDASITFNELHEQVCKF
CCCEEEEEEECCCCEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHH
SNTLKSQGVRKGDVVCIYMPMVAEAAVAMLACTRIGAVHTVVFGGFSPEALAGRIIDSDA
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHCEEECCCC
KVVITADEGVRGGRTVPLKKNVDDALNNPDVTTIEKVVVFQRTGNDIEWSEGRDVWWHEA
EEEEECCCCCCCCEEECCCCCHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCEEEECH
TAVASPHCEPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAITFKYIFDYQEGEV
HCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEHEEEEEEEEEECCCCE
FWCTADVGWITGHTYLIYGPLANGAKTILFEGVPNYPSTSRMSEVVDKHNVNILYTAPTA
EEEECCCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEECHHH
IRALMAQGTEAVQGTSRSSLRVMGSVGEPINPEAWEWYYNTIGDARCPIVDTWWQTETGG
HHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCC
ILISPLPGATALKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVITDSWPGQMRTIYGD
EEEECCCCCCEECCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEECCCCCCEEEEECC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEVESALVAFD
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGVPHDIKGQAIYAYITLNSGEIPSAELHKEVKDWVRKEIGPIATPDFLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
SLPKTRSGKIMRRILRKIATGDTSNLGDTSTLADPSVVDKLIEEQRKIA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA