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The map label for this gene is fnr [H]

Identifier: 172087698

GI number: 172087698

Start: 1457910

End: 1458662

Strand: Direct

Name: fnr [H]

Synonym: VF_1308

Alternate gene names: 172087698

Gene position: 1457910-1458662 (Clockwise)

Preceding gene: 59711914

Following gene: 59711917

Centisome position: 50.32

GC content: 37.98

Gene sequence:

>753_bases
ATGATGTCAGATAACTCAGCAAACAAACGAATTCAGTCAGGCGGTTGTGCTATTCACTGTCAAGATTGTAGTATCAGTCA
GTTATGTATCCCATTTACTTTGAATGATTCTGAATTAGATCAGTTAGATGAGATCATTGAACGTAAAAAGCCTATTCAAA
AAGGCCAAGAGCTATTTAAAGCTGGTGATGAACTGAAGTGTTTATACGCTATACGTTCAGGCACAATCAAAAGCTATACG
ATCACAGAACAAGGTGATGAGCAGATCACTGCATTCCATCTAGCTGGTGATCTCGTTGGTTTTGATGCAATTACGGAAGC
TCAACACCCTAGTTTTGCTCAAGCTCTTGAGACATCGATGGTATGTGAAATTCCTTATGAAATCTTAGATGATTTATCAG
GAAAAATGCCAAAACTTCGTCAGCAAATCATGCGCTTAATGAGTAATGAAATTAAAGGCGACCAAGAAATGATTCTTCTT
CTATCTAAAAAGAATGCAGAAGAACGTTTAGCGGCATTCCTTTACAATCTATCAACTCGTTTTCATCAACGTGGCTTCTC
TCCAAGAGAATTCCGTTTAACAATGACACGTGGTGATATTGGTAACTACCTAGGTTTAACGGTTGAAACAATTAGCCGTT
TATTAGGTCGTTTCCAAAAAACTGAAATGCTAACAGTAAAAGGCAAATACATCACAATCAACGATCATGATGCCCTAGCT
GAGCTTGCCGGTTCTGCGAAAGAAATTAAGTAA

Upstream 100 bases:

>100_bases
GTTAATCGCAAAATTTTTGCATAGTCTTATTTTTATGCTACCACTTTAGTGCGACTTAGTTTAAAATTGACCTATATCAA
ATATAAGAGCATTGAATGAG

Downstream 100 bases:

>100_bases
ATCGTAAAAATTACTGCTTTTAAAAAGTGAGGTATATCTCTTGATGTACCTCACTTTTTTGCATCTAACTTCCCCACTTT
CACTCCCTAACTGCTACAGT

Product: fumarate/nitrate reduction transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MMSDNSANKRIQSGGCAIHCQDCSISQLCIPFTLNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITEAQHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFHQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKTEMLTVKGKYITINDHDALA
ELAGSAKEIK

Sequences:

>Translated_250_residues
MMSDNSANKRIQSGGCAIHCQDCSISQLCIPFTLNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITEAQHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFHQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKTEMLTVKGKYITINDHDALA
ELAGSAKEIK
>Mature_250_residues
MMSDNSANKRIQSGGCAIHCQDCSISQLCIPFTLNDSELDQLDEIIERKKPIQKGQELFKAGDELKCLYAIRSGTIKSYT
ITEQGDEQITAFHLAGDLVGFDAITEAQHPSFAQALETSMVCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILL
LSKKNAEERLAAFLYNLSTRFHQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKTEMLTVKGKYITINDHDALA
ELAGSAKEIK

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=249, Percent_Identity=84.3373493975904, Blast_Score=436, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28120; Mature: 28120

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSDNSANKRIQSGGCAIHCQDCSISQLCIPFTLNDSELDQLDEIIERKKPIQKGQELFK
CCCCCCCHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHH
AGDELKCLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAITEAQHPSFAQALETSM
CCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
VCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILLLSKKNAEERLAAFLYNLSTR
HHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FHQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKTEMLTVKGKYITINDHDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCEEEECCHHHHH
ELAGSAKEIK
HHCCCHHCCC
>Mature Secondary Structure
MMSDNSANKRIQSGGCAIHCQDCSISQLCIPFTLNDSELDQLDEIIERKKPIQKGQELFK
CCCCCCCHHHHHCCCCEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHH
AGDELKCLYAIRSGTIKSYTITEQGDEQITAFHLAGDLVGFDAITEAQHPSFAQALETSM
CCCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHH
VCEIPYEILDDLSGKMPKLRQQIMRLMSNEIKGDQEMILLLSKKNAEERLAAFLYNLSTR
HHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FHQRGFSPREFRLTMTRGDIGNYLGLTVETISRLLGRFQKTEMLTVKGKYITINDHDALA
HHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCEEEECCHHHHH
ELAGSAKEIK
HHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA