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The map label for this gene is sucB [H]

Identifier: 58617586

GI number: 58617586

Start: 1375050

End: 1376258

Strand: Reverse

Name: sucB [H]

Synonym: ERGA_CDS_08590

Alternate gene names: 58617586

Gene position: 1376258-1375050 (Counterclockwise)

Preceding gene: 58617587

Following gene: 58617585

Centisome position: 91.76

GC content: 32.75

Gene sequence:

>1209_bases
ATGAGTGAAGTACAAATAAGGGCTGAAAATCTTGGTGGTGAGTCAATATTAGAAGCTCCAATTCGAGTTTCTGTTAAGAT
TGGTGATAGTATTAAGCAAGGTGATGTATTGTTTATCATTGAAACGGATAAAACTTCTCTCGAAATTGTATCTCCTGTAG
ATGGAACAGTTAGTAAAGTATTTATAGCAGATGAAGAAATTATAGAACGTGATCAACTTTTATGTACAATAAATGTTGGT
GAATTATCACATATTGTCCAGTCTCAAACTCAGGATCCTAAAACAGATAATGGTAATATTATTAATGATGATATTCAGGC
GTTTATACAGAAAAAAGATGCTCCTTCTGCAGTAAAAATTATGGCAGAAAATTCAATTGATAAGAATCAGATCAATGGGT
CTGGTATTGGTGGAAGAATTACAAAATCTGATGTTTTAGACCACATTAATGTTGTTTCAAAAGATCATAGTGTGCTTTCC
GAACAATGTAGTATTACTTCTCATGAGAAGAGAGAAGAACGTGTTAAGATGAGTAAAATTAGGCAGGTGATTGCTGCGAG
ACTTAAGGAGTCTCAAAATACTGCTGCAATATTAACTACGTTTAATGAAGTGGATATGAAGAATGTTATGGATCTTCGTG
TTCAGTATAGGGAGACCTTTGAAAAAAAATATGGTGTCAAACTTGGATTTATGTCTTTTTTTATAAAAGCGGTAGTATTA
GCATTAAAAGAATTACCAGTAATTAATGCTGAGATATCTGGTAATGAGATTATATATAAACATTATTATGATATAGGTAT
TGCTGTAGGGACAGACAAAGGTCTAGTTGTTCCAGTAATGCGTGATGCTGATAAGATGTCTTGTGCTGAGCTTGAGTTAA
CCTTAGCTTCTTTAGGTAAGAAAGCTAGGGAAGGGAAATTAGAAGTTTCAGATATGGCTGGTGCAACTTTTACTATTACT
AATGGTGGAGTATATGGTTCATTATTATCTACTCCTATAATTAATCCTCCTCAGTCTGGTATTTTAGGTATGCACTCTAT
ACAAAAACGACCAGTAGTAGTTAATGATAATTCTATAGAGATTAGACCTATGATGTACATTGCATTATCTTATGATCATA
GAATTGTTGATGGACAAGGTGCTGTAACATTTTTAGTAAGAGTTAAACAGTATATTGAAGATCCAAGTAGAATGTTTCTA
GAAATATAA

Upstream 100 bases:

>100_bases
TTGTATGTAATTTATAGTAAATAAGTAGTTTTTTTTTATTATATTTCATATGTCATTTTTTGTGTTGAGTGTAGTCTAAG
GAATTTTTTATGGTGCATTT

Downstream 100 bases:

>100_bases
ATTTGTATATTGGCATTTCACAATCATAGCAGTAATTGTTTAACATCTTGAGTTTCTGTATATTTTACGAAGTAATGTAT
AAGGTTGCTATCTGACAATA

Product: 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase subunit

Products: NA

Alternate protein names: 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MSEVQIRAENLGGESILEAPIRVSVKIGDSIKQGDVLFIIETDKTSLEIVSPVDGTVSKVFIADEEIIERDQLLCTINVG
ELSHIVQSQTQDPKTDNGNIINDDIQAFIQKKDAPSAVKIMAENSIDKNQINGSGIGGRITKSDVLDHINVVSKDHSVLS
EQCSITSHEKREERVKMSKIRQVIAARLKESQNTAAILTTFNEVDMKNVMDLRVQYRETFEKKYGVKLGFMSFFIKAVVL
ALKELPVINAEISGNEIIYKHYYDIGIAVGTDKGLVVPVMRDADKMSCAELELTLASLGKKAREGKLEVSDMAGATFTIT
NGGVYGSLLSTPIINPPQSGILGMHSIQKRPVVVNDNSIEIRPMMYIALSYDHRIVDGQGAVTFLVRVKQYIEDPSRMFL
EI

Sequences:

>Translated_402_residues
MSEVQIRAENLGGESILEAPIRVSVKIGDSIKQGDVLFIIETDKTSLEIVSPVDGTVSKVFIADEEIIERDQLLCTINVG
ELSHIVQSQTQDPKTDNGNIINDDIQAFIQKKDAPSAVKIMAENSIDKNQINGSGIGGRITKSDVLDHINVVSKDHSVLS
EQCSITSHEKREERVKMSKIRQVIAARLKESQNTAAILTTFNEVDMKNVMDLRVQYRETFEKKYGVKLGFMSFFIKAVVL
ALKELPVINAEISGNEIIYKHYYDIGIAVGTDKGLVVPVMRDADKMSCAELELTLASLGKKAREGKLEVSDMAGATFTIT
NGGVYGSLLSTPIINPPQSGILGMHSIQKRPVVVNDNSIEIRPMMYIALSYDHRIVDGQGAVTFLVRVKQYIEDPSRMFL
EI
>Mature_401_residues
SEVQIRAENLGGESILEAPIRVSVKIGDSIKQGDVLFIIETDKTSLEIVSPVDGTVSKVFIADEEIIERDQLLCTINVGE
LSHIVQSQTQDPKTDNGNIINDDIQAFIQKKDAPSAVKIMAENSIDKNQINGSGIGGRITKSDVLDHINVVSKDHSVLSE
QCSITSHEKREERVKMSKIRQVIAARLKESQNTAAILTTFNEVDMKNVMDLRVQYRETFEKKYGVKLGFMSFFIKAVVLA
LKELPVINAEISGNEIIYKHYYDIGIAVGTDKGLVVPVMRDADKMSCAELELTLASLGKKAREGKLEVSDMAGATFTITN
GGVYGSLLSTPIINPPQSGILGMHSIQKRPVVVNDNSIEIRPMMYIALSYDHRIVDGQGAVTFLVRVKQYIEDPSRMFLE
I

Specific function: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2)

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI19923748, Length=235, Percent_Identity=54.468085106383, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI110671329, Length=427, Percent_Identity=28.3372365339578, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI31711992, Length=415, Percent_Identity=27.9518072289157, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI203098753, Length=439, Percent_Identity=25.7403189066059, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI203098816, Length=439, Percent_Identity=25.7403189066059, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI260898739, Length=161, Percent_Identity=33.5403726708075, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786946, Length=410, Percent_Identity=42.1951219512195, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI1786305, Length=428, Percent_Identity=25.9345794392523, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25146366, Length=397, Percent_Identity=42.0654911838791, Blast_Score=297, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17537937, Length=425, Percent_Identity=29.6470588235294, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17560088, Length=414, Percent_Identity=28.0193236714976, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17538894, Length=235, Percent_Identity=31.063829787234, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320352, Length=390, Percent_Identity=42.3076923076923, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324258, Length=432, Percent_Identity=25, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24645909, Length=227, Percent_Identity=57.2687224669604, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI18859875, Length=429, Percent_Identity=26.8065268065268, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24582497, Length=230, Percent_Identity=32.1739130434783, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI20129315, Length=230, Percent_Identity=32.1739130434783, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053
- InterPro:   IPR006255 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.61 [H]

Molecular weight: Translated: 44399; Mature: 44268

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVQIRAENLGGESILEAPIRVSVKIGDSIKQGDVLFIIETDKTSLEIVSPVDGTVSKV
CCCEEEECCCCCCHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCEEEE
FIADEEIIERDQLLCTINVGELSHIVQSQTQDPKTDNGNIINDDIQAFIQKKDAPSAVKI
EECCHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHCCCCCCEEEE
MAENSIDKNQINGSGIGGRITKSDVLDHINVVSKDHSVLSEQCSITSHEKREERVKMSKI
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHH
RQVIAARLKESQNTAAILTTFNEVDMKNVMDLRVQYRETFEKKYGVKLGFMSFFIKAVVL
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHH
ALKELPVINAEISGNEIIYKHYYDIGIAVGTDKGLVVPVMRDADKMSCAELELTLASLGK
HHHHCCEEEEEECCCEEEEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCC
KAREGKLEVSDMAGATFTITNGGVYGSLLSTPIINPPQSGILGMHSIQKRPVVVNDNSIE
HHHCCCEEEHHCCCCEEEEECCCEEHHHHCCCCCCCCCCCCCCHHHHCCCCEEECCCCEE
IRPMMYIALSYDHRIVDGQGAVTFLVRVKQYIEDPSRMFLEI
EEEEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHEEEC
>Mature Secondary Structure 
SEVQIRAENLGGESILEAPIRVSVKIGDSIKQGDVLFIIETDKTSLEIVSPVDGTVSKV
CCEEEECCCCCCHHHCCCCEEEEEEECCCCCCCCEEEEEECCCCCEEEECCCCCCEEEE
FIADEEIIERDQLLCTINVGELSHIVQSQTQDPKTDNGNIINDDIQAFIQKKDAPSAVKI
EECCHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHCCCCCCEEEE
MAENSIDKNQINGSGIGGRITKSDVLDHINVVSKDHSVLSEQCSITSHEKREERVKMSKI
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHH
RQVIAARLKESQNTAAILTTFNEVDMKNVMDLRVQYRETFEKKYGVKLGFMSFFIKAVVL
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHH
ALKELPVINAEISGNEIIYKHYYDIGIAVGTDKGLVVPVMRDADKMSCAELELTLASLGK
HHHHCCEEEEEECCCEEEEEEEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCC
KAREGKLEVSDMAGATFTITNGGVYGSLLSTPIINPPQSGILGMHSIQKRPVVVNDNSIE
HHHCCCEEEHHCCCCEEEEECCCEEHHHHCCCCCCCCCCCCCCHHHHCCCCEEECCCCEE
IRPMMYIALSYDHRIVDGQGAVTFLVRVKQYIEDPSRMFLEI
EEEEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA