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The map label for this gene is fumC [H]

Identifier: 58617382

GI number: 58617382

Start: 1031693

End: 1033078

Strand: Reverse

Name: fumC [H]

Synonym: ERGA_CDS_06550

Alternate gene names: 58617382

Gene position: 1033078-1031693 (Counterclockwise)

Preceding gene: 58617385

Following gene: 58617381

Centisome position: 68.88

GC content: 32.97

Gene sequence:

>1386_bases
ATGAGAAAAGAAAAAGATAGTTTAGGAGAGGTGAATGTACCAGCATGTCACTATTGGGGAGCACAAACACAGCGTTCTAT
TGATAATTTTAAAATTGGCTCGGAGAAAATGCCTAAACCTTTGATAAGAGCGATGGGGATTGTAAAATTAGCTGCAGCAC
GCGTTAATATGAAAAATGGTGATATAAATGAGGTAATAGGTAATGCAATTTGTAATGCTGCTGCTGAGGTTATAGATGGT
AAGTTAGATAGTGAATTTCCTCTGGTAGTATGGCAGACTGGTTCTGGTACTCAAACTAATATGAATGTTAATGAGGTTAT
AGCAAATCGTGCGATTGAAATTTTAGGTGGTGAAAAGGGTAGTAAAGTTCCAGTTCATCCAAATGATCATGTGAATTATT
CTCAGTCTTCAAATGATACTTTTCCGACAGCAATGCATATTGCTACTGTTAGTGAAACTGAAAACTATTTATTACCGAGT
CTTAAAAATTTATATGATGCACTACATAGTAAGTCTATAGCATTTCAAAATATTGTCAAAGTGGGACGTACTCATCTTCA
AGATGCAACTCCGCTAACTTTAGGGCAAGAGTTTTCTGGTTATGCATATCAAGTTTTACAAGGGATTGGCAGAATCAAAT
CAGCATTAAGTAATTTGCTTGAGTTAGCACAGGGTGGTACTGCAGTAGGTACTGGTATTAATTCTAGGAAGCAATTTGAT
GTTCATATTGCCAATGAAATAAAAAAAATTACAGGTTTTAATTTTGTTTCTTCTGTAAATAAGTTTGAAGCTTTGGCTAC
ACATGATGCACTAGTTGAGTTTAGTGGTGCATTAAATGTACTTGCTGTTAGTTTGATGAAAATTGCTAATGATATTAGAT
TACTGAGCTCTGGTCCAAGATGTGGTATAGGGGAAATTATATTACCTGCAAATGAGCCAGGGTCATCTATCATGCCAGGG
AAAGTTAATCCTACTCAATGTGAGGCGGTTACTATGGTATGTGCTCAAGTTATGGGTAATAATATGACTGTTAGTATTGC
TGGATCAAATGGTCATTTTGAATTGAATACATTTAAACCTGTAATTATTTATAATATTTTACAATCTATTAGATTACTAT
CTGATGTTAGTGTTAATTTTGTACAGAAGTGTATATACGGAATAAGGGCTGATACAAAACGTATTGCATTTTTACTGAAT
CAGTCTCTAATGTTAGTAACAGCATTAAATAAATATATAGGTTATGATAATGCAGCTAAAATATCAAAAACTGCTTTTGA
AGAAGGTATAACTTTAAAAGATGCTGCTATGAAGTTAAAGTTAATAAGTGAAGAAGAATTTGATAAAATTATAAATCCTG
AAAATATGATATATCCTGATAATTAA

Upstream 100 bases:

>100_bases
CTATTTTTTAAATCTGTTTGTTCAGATCAGCTATATAAGTAGACATGTTTGAGAAACTGAATTATAAACTTTTATAAATA
GGAAAAGATTAAGTAAAGTT

Downstream 100 bases:

>100_bases
TGTATTATTGTGTGCTATTAAGATCGTATAAACTTCTTTTATGCAATAATATTGACATCTTCCATTATATGGTTATAATC
AGTAGAATTATAGTATTTTG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MRKEKDSLGEVNVPACHYWGAQTQRSIDNFKIGSEKMPKPLIRAMGIVKLAAARVNMKNGDINEVIGNAICNAAAEVIDG
KLDSEFPLVVWQTGSGTQTNMNVNEVIANRAIEILGGEKGSKVPVHPNDHVNYSQSSNDTFPTAMHIATVSETENYLLPS
LKNLYDALHSKSIAFQNIVKVGRTHLQDATPLTLGQEFSGYAYQVLQGIGRIKSALSNLLELAQGGTAVGTGINSRKQFD
VHIANEIKKITGFNFVSSVNKFEALATHDALVEFSGALNVLAVSLMKIANDIRLLSSGPRCGIGEIILPANEPGSSIMPG
KVNPTQCEAVTMVCAQVMGNNMTVSIAGSNGHFELNTFKPVIIYNILQSIRLLSDVSVNFVQKCIYGIRADTKRIAFLLN
QSLMLVTALNKYIGYDNAAKISKTAFEEGITLKDAAMKLKLISEEEFDKIINPENMIYPDN

Sequences:

>Translated_461_residues
MRKEKDSLGEVNVPACHYWGAQTQRSIDNFKIGSEKMPKPLIRAMGIVKLAAARVNMKNGDINEVIGNAICNAAAEVIDG
KLDSEFPLVVWQTGSGTQTNMNVNEVIANRAIEILGGEKGSKVPVHPNDHVNYSQSSNDTFPTAMHIATVSETENYLLPS
LKNLYDALHSKSIAFQNIVKVGRTHLQDATPLTLGQEFSGYAYQVLQGIGRIKSALSNLLELAQGGTAVGTGINSRKQFD
VHIANEIKKITGFNFVSSVNKFEALATHDALVEFSGALNVLAVSLMKIANDIRLLSSGPRCGIGEIILPANEPGSSIMPG
KVNPTQCEAVTMVCAQVMGNNMTVSIAGSNGHFELNTFKPVIIYNILQSIRLLSDVSVNFVQKCIYGIRADTKRIAFLLN
QSLMLVTALNKYIGYDNAAKISKTAFEEGITLKDAAMKLKLISEEEFDKIINPENMIYPDN
>Mature_461_residues
MRKEKDSLGEVNVPACHYWGAQTQRSIDNFKIGSEKMPKPLIRAMGIVKLAAARVNMKNGDINEVIGNAICNAAAEVIDG
KLDSEFPLVVWQTGSGTQTNMNVNEVIANRAIEILGGEKGSKVPVHPNDHVNYSQSSNDTFPTAMHIATVSETENYLLPS
LKNLYDALHSKSIAFQNIVKVGRTHLQDATPLTLGQEFSGYAYQVLQGIGRIKSALSNLLELAQGGTAVGTGINSRKQFD
VHIANEIKKITGFNFVSSVNKFEALATHDALVEFSGALNVLAVSLMKIANDIRLLSSGPRCGIGEIILPANEPGSSIMPG
KVNPTQCEAVTMVCAQVMGNNMTVSIAGSNGHFELNTFKPVIIYNILQSIRLLSDVSVNFVQKCIYGIRADTKRIAFLLN
QSLMLVTALNKYIGYDNAAKISKTAFEEGITLKDAAMKLKLISEEEFDKIINPENMIYPDN

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=63.3405639913232, Blast_Score=594, Evalue=1e-170,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=55.5555555555556, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=57.9868708971554, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=40.04329004329, Blast_Score=330, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=63.3405639913232, Blast_Score=603, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI32565146, Length=326, Percent_Identity=62.2699386503067, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=61.822125813449, Blast_Score=572, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=61.038961038961, Blast_Score=573, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=61.038961038961, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=59.95670995671, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=57.1428571428571, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=51.6198704103672, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50105; Mature: 50105

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKEKDSLGEVNVPACHYWGAQTQRSIDNFKIGSEKMPKPLIRAMGIVKLAAARVNMKNG
CCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
DINEVIGNAICNAAAEVIDGKLDSEFPLVVWQTGSGTQTNMNVNEVIANRAIEILGGEKG
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCC
SKVPVHPNDHVNYSQSSNDTFPTAMHIATVSETENYLLPSLKNLYDALHSKSIAFQNIVK
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
VGRTHLQDATPLTLGQEFSGYAYQVLQGIGRIKSALSNLLELAQGGTAVGTGINSRKQFD
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEE
VHIANEIKKITGFNFVSSVNKFEALATHDALVEFSGALNVLAVSLMKIANDIRLLSSGPR
EEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CGIGEIILPANEPGSSIMPGKVNPTQCEAVTMVCAQVMGNNMTVSIAGSNGHFELNTFKP
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCH
VIIYNILQSIRLLSDVSVNFVQKCIYGIRADTKRIAFLLNQSLMLVTALNKYIGYDNAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
ISKTAFEEGITLKDAAMKLKLISEEEFDKIINPENMIYPDN
HHHHHHHCCCEEHHHHHEEEECCHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MRKEKDSLGEVNVPACHYWGAQTQRSIDNFKIGSEKMPKPLIRAMGIVKLAAARVNMKNG
CCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
DINEVIGNAICNAAAEVIDGKLDSEFPLVVWQTGSGTQTNMNVNEVIANRAIEILGGEKG
CHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHEECCCCC
SKVPVHPNDHVNYSQSSNDTFPTAMHIATVSETENYLLPSLKNLYDALHSKSIAFQNIVK
CCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHH
VGRTHLQDATPLTLGQEFSGYAYQVLQGIGRIKSALSNLLELAQGGTAVGTGINSRKQFD
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCEEE
VHIANEIKKITGFNFVSSVNKFEALATHDALVEFSGALNVLAVSLMKIANDIRLLSSGPR
EEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
CGIGEIILPANEPGSSIMPGKVNPTQCEAVTMVCAQVMGNNMTVSIAGSNGHFELNTFKP
CCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCH
VIIYNILQSIRLLSDVSVNFVQKCIYGIRADTKRIAFLLNQSLMLVTALNKYIGYDNAAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHH
ISKTAFEEGITLKDAAMKLKLISEEEFDKIINPENMIYPDN
HHHHHHHCCCEEHHHHHEEEECCHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA