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The map label for this gene is tktA [H]

Identifier: 58617305

GI number: 58617305

Start: 937938

End: 939953

Strand: Reverse

Name: tktA [H]

Synonym: ERGA_CDS_05780

Alternate gene names: 58617305

Gene position: 939953-937938 (Counterclockwise)

Preceding gene: 58617306

Following gene: 58617300

Centisome position: 62.67

GC content: 33.63

Gene sequence:

>2016_bases
ATGAGTCAAAAATATAGTAATATGATTGCCATGGCTAATGCTGTAAGAGTACTTTCAATAGATGCTATACAAAAAGCCGC
TTCTGGACATCCAGGTATGCCTCTTGGTATGGCAGATGTAGGAACTATGTTATTTGCTAAATTTTTAAAATTTAATCCTA
AGGATCCTAATTGGTTTGATAGGGATAGGTTTGTTTTATCAAATGGACATGGGTCAATGTTATTGTATTCTATATTATAT
TTCTTAGGATGTTTGGATATAGAAGAGATAAAAAAGTTTAGGCAAATACATTCTCTAACACCTGGCCATCCAGAATATGG
TTGTACTCCTGGAGTTGATGCTACAACTGGTCCGCTAGGTCAGGGATTGGCTTCTGCTGTGGGTATGGCAATAGCAGAAA
AAATACTATCTGAAAAATTTGGAGCTGATATTGTATCTCATAATACTTATGTTATGGTTGGGGATGGATGTCTTATGGAG
GGAATTAGCCATGAAGCTGCGTCTTTAGCTGGGCATTTGCAGTTAGATAAATTAATAGTATTATTTGATGATAATAATGT
TTCTATCGATGGTCCTATATCATTGTCCGTTTCTGATAATGTTAAAGGTAGATTTTTATCTTATGGATGGGATGTTGATG
AAATAGATGGGCATGATTTTTCTCAGATTGAATCATCAATTAAAAATGCAAAAAATTCTAAAAAGCCATCTCTAATTTGT
TGTAAGACTATTATTGGTAAAACTATTCCTTCAAAAGAAAATACTTGTGATATACATAGTTGGCCAGTGACTGAAGAAGA
TATAATTGTAATGAAGAAGAGATTAGGGTGGGCTTATAAGCCATTTGAGTTCCCAGAGGAAATTCTGCAATTATGGCAAG
ATATTGCGTGTAATTCAGAGGAAGAGTATAAATTATGGGTAGAGCGAGTTAGTGAGTATGGCAAGACATCACAAGATTTT
ATGGATGTGATGGCTGACGGTGTATCTAATAAGGTTTTTTTGAATTTGAAGAGTTTAAAAGAAGAATTATGTAGCTTGAA
TTTGAATGAAGCAACACGTAAATCTTCAGGTAGAGTATTAGACGTTATAATGGGTAGTACTGGTAAGTTGATAGGTGGTT
CTGCAGATCTTAGTAATTCTAATAATACTAAACCAAAATTTACATCGGTAATTAATAAAGATAATTTCTCTGGTTCTTAT
TTACATTATGGAGTTAGAGAGCATGCTATGGCAGCATGTATGAATGGTATGGCATTGCATAAGGGAGTAATCCCTTATGG
TGGTACATTTTTGATTTTCTCTGATTATTGTAGACCAGCTATAAGGTTGTCTGCCTTAATGAAAAGGCAAGTTATTTATA
TTATGACCCATGATTCAATAGGGGTTGGGGAAGATGGTCCTACTCATCAACCTGTTGAGCATCTACCATCTTTGAGGTTA
ATTCCTAATTTGTATGTTTTTAGACCAGCTGATGCTATAGAAGTATTAGAGTGTTGGGAGATTGCATTAAAGTTAATAGA
TGCTCCATCGGTTCTGATATTATCTAGACAGAATGTTAAATGTGTACGTAGTACTTATGTTGCAGAGAATATGTCAAGCA
AAGGTGCATATATTATTCGTGAATATAAGAATGATCTCGATGTAACAATTTTTGCTACTGGGTCTGAGGTTGAGATAGCA
TTAAAAGCAAGTGATATTTTAATAGGTAAAGGATTAGGTGTCCGGGTAGTTTCTGTACCTTGTTGGGAATTGTTTTATAA
ACAAGATAAAAAATATATTATAAGTCTGTTAAATAATAAAAGTATAAAGGCAGCAGTAGAAGCTGCTAGTTCATTTGGTT
GGTGTAAGTATATAGGAGAAGATGGAATTTTTGTAGGTTTGGAAGATTTTGGAATATCTGCTCCATTCAAAGATTTGTAT
AAGTATTTTGGAATTACTCCAGAAAACTTAGTGGATAAAATACTCAGTAAATTAAGAATTAATAGTAATTACGAAAGTAA
TGTTACTGCGGATTGA

Upstream 100 bases:

>100_bases
TTTTATAAAAATTACTTAGTGGATAAGTATTTAAAAGTATAATTACGATATGTATTATTATGTTACTGTGTAAATTATAT
AAAATTAATGAGATAAGCAT

Downstream 100 bases:

>100_bases
TTGTTATAGTCTTCATTGTGATTGTATTGATAGAGAATTATCACATTGTATTATTTTTAGATAAATCTATTGCTTTTTCT
GTTTATGTCTTCTTAGCAGC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 671; Mature: 670

Protein sequence:

>671_residues
MSQKYSNMIAMANAVRVLSIDAIQKAASGHPGMPLGMADVGTMLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILY
FLGCLDIEEIKKFRQIHSLTPGHPEYGCTPGVDATTGPLGQGLASAVGMAIAEKILSEKFGADIVSHNTYVMVGDGCLME
GISHEAASLAGHLQLDKLIVLFDDNNVSIDGPISLSVSDNVKGRFLSYGWDVDEIDGHDFSQIESSIKNAKNSKKPSLIC
CKTIIGKTIPSKENTCDIHSWPVTEEDIIVMKKRLGWAYKPFEFPEEILQLWQDIACNSEEEYKLWVERVSEYGKTSQDF
MDVMADGVSNKVFLNLKSLKEELCSLNLNEATRKSSGRVLDVIMGSTGKLIGGSADLSNSNNTKPKFTSVINKDNFSGSY
LHYGVREHAMAACMNGMALHKGVIPYGGTFLIFSDYCRPAIRLSALMKRQVIYIMTHDSIGVGEDGPTHQPVEHLPSLRL
IPNLYVFRPADAIEVLECWEIALKLIDAPSVLILSRQNVKCVRSTYVAENMSSKGAYIIREYKNDLDVTIFATGSEVEIA
LKASDILIGKGLGVRVVSVPCWELFYKQDKKYIISLLNNKSIKAAVEAASSFGWCKYIGEDGIFVGLEDFGISAPFKDLY
KYFGITPENLVDKILSKLRINSNYESNVTAD

Sequences:

>Translated_671_residues
MSQKYSNMIAMANAVRVLSIDAIQKAASGHPGMPLGMADVGTMLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILY
FLGCLDIEEIKKFRQIHSLTPGHPEYGCTPGVDATTGPLGQGLASAVGMAIAEKILSEKFGADIVSHNTYVMVGDGCLME
GISHEAASLAGHLQLDKLIVLFDDNNVSIDGPISLSVSDNVKGRFLSYGWDVDEIDGHDFSQIESSIKNAKNSKKPSLIC
CKTIIGKTIPSKENTCDIHSWPVTEEDIIVMKKRLGWAYKPFEFPEEILQLWQDIACNSEEEYKLWVERVSEYGKTSQDF
MDVMADGVSNKVFLNLKSLKEELCSLNLNEATRKSSGRVLDVIMGSTGKLIGGSADLSNSNNTKPKFTSVINKDNFSGSY
LHYGVREHAMAACMNGMALHKGVIPYGGTFLIFSDYCRPAIRLSALMKRQVIYIMTHDSIGVGEDGPTHQPVEHLPSLRL
IPNLYVFRPADAIEVLECWEIALKLIDAPSVLILSRQNVKCVRSTYVAENMSSKGAYIIREYKNDLDVTIFATGSEVEIA
LKASDILIGKGLGVRVVSVPCWELFYKQDKKYIISLLNNKSIKAAVEAASSFGWCKYIGEDGIFVGLEDFGISAPFKDLY
KYFGITPENLVDKILSKLRINSNYESNVTAD
>Mature_670_residues
SQKYSNMIAMANAVRVLSIDAIQKAASGHPGMPLGMADVGTMLFAKFLKFNPKDPNWFDRDRFVLSNGHGSMLLYSILYF
LGCLDIEEIKKFRQIHSLTPGHPEYGCTPGVDATTGPLGQGLASAVGMAIAEKILSEKFGADIVSHNTYVMVGDGCLMEG
ISHEAASLAGHLQLDKLIVLFDDNNVSIDGPISLSVSDNVKGRFLSYGWDVDEIDGHDFSQIESSIKNAKNSKKPSLICC
KTIIGKTIPSKENTCDIHSWPVTEEDIIVMKKRLGWAYKPFEFPEEILQLWQDIACNSEEEYKLWVERVSEYGKTSQDFM
DVMADGVSNKVFLNLKSLKEELCSLNLNEATRKSSGRVLDVIMGSTGKLIGGSADLSNSNNTKPKFTSVINKDNFSGSYL
HYGVREHAMAACMNGMALHKGVIPYGGTFLIFSDYCRPAIRLSALMKRQVIYIMTHDSIGVGEDGPTHQPVEHLPSLRLI
PNLYVFRPADAIEVLECWEIALKLIDAPSVLILSRQNVKCVRSTYVAENMSSKGAYIIREYKNDLDVTIFATGSEVEIAL
KASDILIGKGLGVRVVSVPCWELFYKQDKKYIISLLNNKSIKAAVEAASSFGWCKYIGEDGIFVGLEDFGISAPFKDLYK
YFGITPENLVDKILSKLRINSNYESNVTAD

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=586, Percent_Identity=26.4505119453925, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI4507521, Length=586, Percent_Identity=26.4505119453925, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI133778974, Length=570, Percent_Identity=28.7719298245614, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI225637459, Length=573, Percent_Identity=23.9092495636998, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI225637461, Length=545, Percent_Identity=23.302752293578, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI225637463, Length=542, Percent_Identity=23.4317343173432, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1788808, Length=654, Percent_Identity=47.5535168195719, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI48994911, Length=654, Percent_Identity=46.177370030581, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=500, Percent_Identity=28, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325331, Length=656, Percent_Identity=41.1585365853659, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6319593, Length=687, Percent_Identity=38.8646288209607, Blast_Score=439, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45551847, Length=572, Percent_Identity=27.2727272727273, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI45550715, Length=572, Percent_Identity=27.2727272727273, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24666278, Length=578, Percent_Identity=26.643598615917, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24645119, Length=541, Percent_Identity=26.8022181146026, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 74169; Mature: 74038

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKYSNMIAMANAVRVLSIDAIQKAASGHPGMPLGMADVGTMLFAKFLKFNPKDPNWFD
CCCHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSNGHGSMLLYSILYFLGCLDIEEIKKFRQIHSLTPGHPEYGCTPGVDATTGPLG
CCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGLASAVGMAIAEKILSEKFGADIVSHNTYVMVGDGCLMEGISHEAASLAGHLQLDKLIV
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCHHHHCCCHHHHHHHCCEEEEEEEE
LFDDNNVSIDGPISLSVSDNVKGRFLSYGWDVDEIDGHDFSQIESSIKNAKNSKKPSLIC
EECCCCEEECCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
CKTIIGKTIPSKENTCDIHSWPVTEEDIIVMKKRLGWAYKPFEFPEEILQLWQDIACNSE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EEYKLWVERVSEYGKTSQDFMDVMADGVSNKVFLNLKSLKEELCSLNLNEATRKSSGRVL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCHHHHCCCCCEE
DVIMGSTGKLIGGSADLSNSNNTKPKFTSVINKDNFSGSYLHYGVREHAMAACMNGMALH
EEEECCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHCCHHHH
KGVIPYGGTFLIFSDYCRPAIRLSALMKRQVIYIMTHDSIGVGEDGPTHQPVEHLPSLRL
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHCCCCEE
IPNLYVFRPADAIEVLECWEIALKLIDAPSVLILSRQNVKCVRSTYVAENMSSKGAYIIR
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEE
EYKNDLDVTIFATGSEVEIALKASDILIGKGLGVRVVSVPCWELFYKQDKKYIISLLNNK
EECCCCCEEEEEECCEEEEEEEECEEEEECCCCEEEEECHHHHHHHHHCHHHHHHHHCCC
SIKAAVEAASSFGWCKYIGEDGIFVGLEDFGISAPFKDLYKYFGITPENLVDKILSKLRI
CHHHHHHHHHCCCEEEEECCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
NSNYESNVTAD
CCCCCCCCCCC
>Mature Secondary Structure 
SQKYSNMIAMANAVRVLSIDAIQKAASGHPGMPLGMADVGTMLFAKFLKFNPKDPNWFD
CCHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
RDRFVLSNGHGSMLLYSILYFLGCLDIEEIKKFRQIHSLTPGHPEYGCTPGVDATTGPLG
CCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
QGLASAVGMAIAEKILSEKFGADIVSHNTYVMVGDGCLMEGISHEAASLAGHLQLDKLIV
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEECCCHHHHCCCHHHHHHHCCEEEEEEEE
LFDDNNVSIDGPISLSVSDNVKGRFLSYGWDVDEIDGHDFSQIESSIKNAKNSKKPSLIC
EECCCCEEECCCEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEE
CKTIIGKTIPSKENTCDIHSWPVTEEDIIVMKKRLGWAYKPFEFPEEILQLWQDIACNSE
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCC
EEYKLWVERVSEYGKTSQDFMDVMADGVSNKVFLNLKSLKEELCSLNLNEATRKSSGRVL
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCCHHHHCCCCCEE
DVIMGSTGKLIGGSADLSNSNNTKPKFTSVINKDNFSGSYLHYGVREHAMAACMNGMALH
EEEECCCCCEECCCCCCCCCCCCCCHHHHHHCCCCCCCCCEECCHHHHHHHHHHCCHHHH
KGVIPYGGTFLIFSDYCRPAIRLSALMKRQVIYIMTHDSIGVGEDGPTHQPVEHLPSLRL
CCCCCCCCEEEEEHHHCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCHHHCCCCEE
IPNLYVFRPADAIEVLECWEIALKLIDAPSVLILSRQNVKCVRSTYVAENMSSKGAYIIR
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEE
EYKNDLDVTIFATGSEVEIALKASDILIGKGLGVRVVSVPCWELFYKQDKKYIISLLNNK
EECCCCCEEEEEECCEEEEEEEECEEEEECCCCEEEEECHHHHHHHHHCHHHHHHHHCCC
SIKAAVEAASSFGWCKYIGEDGIFVGLEDFGISAPFKDLYKYFGITPENLVDKILSKLRI
CHHHHHHHHHCCCEEEEECCCCEEEEEHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCC
NSNYESNVTAD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA