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The map label for this gene is argB

Identifier: 58617187

GI number: 58617187

Start: 747809

End: 748777

Strand: Reverse

Name: argB

Synonym: ERGA_CDS_04600

Alternate gene names: 58617187

Gene position: 748777-747809 (Counterclockwise)

Preceding gene: 58617188

Following gene: 58617186

Centisome position: 49.92

GC content: 31.37

Gene sequence:

>969_bases
ATGAAATTGCGCAATGTATCAAAAAATAATCTTAATAAAGAAGATACCAAATTGAGCATTGAGCAATTTGGTGGAAATGT
TGAGTGGTTTAATATTACTAAAACTTTATCAGAGTCTTTGCCTTATATACAGCAATTTTCTGGTGAAACATTTATTATTA
AGTATGGTGGTGCTGCCATGACGGATAAAAAATTGGCAGAGAGCTTTGCCCATGATGTTGTATTACTCAAGCAGCTTGGA
ATTAACCCAATAGTTGTACATGGAGGAGGAAATAAGATTAATGAATTTTTAGAGAAGATAAATAAGAAAAGTACATTCAT
TAACGGATTAAGGATTACTGATGCTGAAACACTAGAAATTGTAGAAATGGTACTTTGTGGATTAGTGAATAAAAATATTA
CACAGCTGATTAATAATGCTGGAGGTAATGCTATTGGATTATGTGGTAAAGATGCTAATTTAATAGAAGCAAAGAAAATT
TGTTATACTTATAAAGAGAATCAATCGAATAATGTTGAAAAAATTTTAGATATGGGTTTTGTTGGTGAGCCTCATGATAT
TAATACAGATCTGTTATTTTTTATGGAGGAATCTGATTTTATTCCTGTAATAGCTCCTGTGTGTAGTGGTGAAAATAATT
TAACATATAATGTGAATGCTGATCTAGTAGCTGGTGCTCTTGCAAATGCTATGGCTGCTGCTAAGTTAATTATTTTAACA
AATGTTTCAGGGGTAACTGATAGTAATGGTAATTTAATATCTGAATTATCAGTAAGTCATGCAGAAAATCTTATTGATAA
TGGTACTGCACATACAGGTATGATTCCTAAGCTACAAACTTGTGTTAAAGTAGTTAAAGAAGGTTACGGTTCTGCTCATA
TTATTGATGGTAGAATACCTCATGTATTATTGTTGGAGTTATTTACTATTCATGGTACTGGTACAATGGTGGTGAATTCA
GGAGTATAA

Upstream 100 bases:

>100_bases
GTTATTGTAAGTGATGTTCAAAACTTCAACCTGAATTTTATTATATATCCAATCATTAATGTTAGTAGTAAGTGTAAACA
AGGAATAGAGGAGTTAATTT

Downstream 100 bases:

>100_bases
TATGTGCTTTATAGTTGGGATATAATTAAAAAAGTTACATATGAACAAGTAAGTAAAGAAGAATTAGGTGGAACTACAGT
CTATGCTGCTAAAACAGGAA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MKLRNVSKNNLNKEDTKLSIEQFGGNVEWFNITKTLSESLPYIQQFSGETFIIKYGGAAMTDKKLAESFAHDVVLLKQLG
INPIVVHGGGNKINEFLEKINKKSTFINGLRITDAETLEIVEMVLCGLVNKNITQLINNAGGNAIGLCGKDANLIEAKKI
CYTYKENQSNNVEKILDMGFVGEPHDINTDLLFFMEESDFIPVIAPVCSGENNLTYNVNADLVAGALANAMAAAKLIILT
NVSGVTDSNGNLISELSVSHAENLIDNGTAHTGMIPKLQTCVKVVKEGYGSAHIIDGRIPHVLLLELFTIHGTGTMVVNS
GV

Sequences:

>Translated_322_residues
MKLRNVSKNNLNKEDTKLSIEQFGGNVEWFNITKTLSESLPYIQQFSGETFIIKYGGAAMTDKKLAESFAHDVVLLKQLG
INPIVVHGGGNKINEFLEKINKKSTFINGLRITDAETLEIVEMVLCGLVNKNITQLINNAGGNAIGLCGKDANLIEAKKI
CYTYKENQSNNVEKILDMGFVGEPHDINTDLLFFMEESDFIPVIAPVCSGENNLTYNVNADLVAGALANAMAAAKLIILT
NVSGVTDSNGNLISELSVSHAENLIDNGTAHTGMIPKLQTCVKVVKEGYGSAHIIDGRIPHVLLLELFTIHGTGTMVVNS
GV
>Mature_322_residues
MKLRNVSKNNLNKEDTKLSIEQFGGNVEWFNITKTLSESLPYIQQFSGETFIIKYGGAAMTDKKLAESFAHDVVLLKQLG
INPIVVHGGGNKINEFLEKINKKSTFINGLRITDAETLEIVEMVLCGLVNKNITQLINNAGGNAIGLCGKDANLIEAKKI
CYTYKENQSNNVEKILDMGFVGEPHDINTDLLFFMEESDFIPVIAPVCSGENNLTYNVNADLVAGALANAMAAAKLIILT
NVSGVTDSNGNLISELSVSHAENLIDNGTAHTGMIPKLQTCVKVVKEGYGSAHIIDGRIPHVLLLELFTIHGTGTMVVNS
GV

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=287, Percent_Identity=28.2229965156794, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI145693208, Length=237, Percent_Identity=27.4261603375527, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320913, Length=287, Percent_Identity=24.0418118466899, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_EHRRG (Q5FGU6)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196386.1
- HSSP:   Q9HTN2
- ProteinModelPortal:   Q5FGU6
- SMR:   Q5FGU6
- STRING:   Q5FGU6
- GeneID:   3268233
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_04600
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- ProtClustDB:   PRK00942
- BioCyc:   ERUM302409:ERGA_CDS_04600-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 34851; Mature: 34851

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: BINDING 111-111 BINDING 217-217

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRNVSKNNLNKEDTKLSIEQFGGNVEWFNITKTLSESLPYIQQFSGETFIIKYGGAAM
CCCCCCCCCCCCCHHHEEEHHHCCCCEEEEEHHHHHHHCCCHHHHCCCCEEEEEECCCCC
TDKKLAESFAHDVVLLKQLGINPIVVHGGGNKINEFLEKINKKSTFINGLRITDAETLEI
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHEECCEEECCHHHHHH
VEMVLCGLVNKNITQLINNAGGNAIGLCGKDANLIEAKKICYTYKENQSNNVEKILDMGF
HHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHEEECCCCCCCHHHHHHHCC
VGEPHDINTDLLFFMEESDFIPVIAPVCSGENNLTYNVNADLVAGALANAMAAAKLIILT
CCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHEEEEEE
NVSGVTDSNGNLISELSVSHAENLIDNGTAHTGMIPKLQTCVKVVKEGYGSAHIIDGRIP
ECCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCH
HVLLLELFTIHGTGTMVVNSGV
HHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MKLRNVSKNNLNKEDTKLSIEQFGGNVEWFNITKTLSESLPYIQQFSGETFIIKYGGAAM
CCCCCCCCCCCCCHHHEEEHHHCCCCEEEEEHHHHHHHCCCHHHHCCCCEEEEEECCCCC
TDKKLAESFAHDVVLLKQLGINPIVVHGGGNKINEFLEKINKKSTFINGLRITDAETLEI
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHEECCEEECCHHHHHH
VEMVLCGLVNKNITQLINNAGGNAIGLCGKDANLIEAKKICYTYKENQSNNVEKILDMGF
HHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHEEECCCCCCCHHHHHHHCC
VGEPHDINTDLLFFMEESDFIPVIAPVCSGENNLTYNVNADLVAGALANAMAAAKLIILT
CCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHEEEEEE
NVSGVTDSNGNLISELSVSHAENLIDNGTAHTGMIPKLQTCVKVVKEGYGSAHIIDGRIP
ECCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCH
HVLLLELFTIHGTGTMVVNSGV
HHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA