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The map label for this gene is uvrD [H]

Identifier: 58616965

GI number: 58616965

Start: 385826

End: 387745

Strand: Reverse

Name: uvrD [H]

Synonym: ERGA_CDS_02380

Alternate gene names: 58616965

Gene position: 387745-385826 (Counterclockwise)

Preceding gene: 58616966

Following gene: 58616964

Centisome position: 25.85

GC content: 29.69

Gene sequence:

>1920_bases
ATGGAAGATTACATTACTTCACTAAATGAAGATCAGAAGAAAGCCGTTACTAATATTAATGGACCTATTTTAATATTAGC
TGGAGCAGGAACAGGTAAAACCAGAACTATTACATCAAGAATAGCATATATTCTTAATAACAATTTTGCACTTCCTAATC
AAATTTTAGCTGTCACATTTACTAACAAAGCTGCTAATGAAATGCTTTCAAGAATCAATGAATTAACCTGTGCATCAAAC
ATATGGCTGGGTACGTTTCATGCAATAGCAACAAAAATCCTTCGACAACATGCTGAAGCAGTAGGCTTAAAAAGTGATTT
TACCATCATTGGCACAGATGATCAATTGCAAGTAATCAAGACTATAGTTAATGACATGCATCCTGAATATGCATCAGATG
CTTATAAAATTATTTTAAACAAAATACAAAGATGGAAAGATAGAGGATTAGTACCTACAAATATAAGTGATACAGAATTA
AATAAACCCATCAATACAATAGCATTAAGTACCTATAACATTTATCAAGAACGACTAAAGTTTCTTAACTGTGCTGATTT
TGGGGATTTACTATTATATAACATCGAAATATTTACCAAACAGCATAATATTTTATCACATTATCAAGAACAGTTTAAAT
ACATCATGGTTGATGAATATCAAGATATCAACACGATTCAATATTTATGGTTGAGATTACTAGCACAAAAACATAAGAAC
TTATGTTGTGTTGGAGATGATGATCAATCAATATATAGTTGGCGTGGGGCAGAAGTAGGAAATATATTAAAATTCTCAGA
TGATTTCCCTAATGCAAAAACTATACGTCTAGAATGCAATTATAGATCAACATCAAATATACTAGAAGTTGCTACGGCAA
TAATAAATAATAATAAGTCTAGGTTAGGAAAAAAATTATGGACAACAAATCAAGAAGGAAACAAAGTTAATTTGATGAAG
TTTTGGGATAGTAGAATAGAAGCACAATATATATGCGAATATATAAAGAATTTACACGATTATCAATTTAAAGAAACAGC
TATTTTAGTAAGAGCAGGATTTCAAACTAGAATATTTGAAGAATATTTTATTAAGTACAATATACCATATAGAATAATTG
GAAGTACAAGATTTTATGATCGGCAAGAAATTCGAGATATTATTGCATACTTAAAAATTACTGTAAATCCTCAGCATGAC
ATTGCTTTTGATAGAATCATTAATAAACCCAAACGAAATGTTGGAGCATCCACTTTAAATAAAATATACTCATATGCAAA
GCAGTATAATACCCACTTTTTAGATGCTACAAAAATATTAATTGAAAATAATCAGCTCTCAGAAAAAACATCAAGATCAT
TAAATAACCTGCTAAACAAGATCAATTCTTGGAAGGAATCCTTATTATCAGATTCAATATCAAATACTGTGAAGATGATA
GCATATGATTCAGGATACATAGATATGCTAGAGAATGAAGGAGAAAGTGGATTAGCACGTATAGAAAACATAAAAGAATT
ATTCTCTGCATTACTAAATTTCAATGATGTAAATGCATTTTTAGAACATATTAGTCTTGTAACAGAAGTGGATATATCAA
ATGATGATGACAATTATACGTGTATAATGACATTACATGCAGCAAAAGGCCTAGAATTTCCTGTGGTTTTTTTACCAGGA
TGGGAAGAAGGAGTTTTTCCACATGAAAAATCTTTACAAGATAGAACAGGAGAAGCTTTGGAAGAAGAAAGAAGATTAGC
ATATGTTGGAATTACAAGAGCAAGAGAACAGTTATTCATATCATGTGTAGCGGTAAGAGACATAAACAATTGGCGTCAAC
AAATGGAAATATCACGTTTTATAAAAGAATTACCTATAGAACATATACAGGTTATAAAAAATATATCAAATTACCACTAA

Upstream 100 bases:

>100_bases
ATAAAGAAGTAATTTGTATTCGACTAAATCTCTATCTTTTTTTGACTGTATTACTAAAATATAACATACTACATATTAAT
AATGATAAACCTATTACATT

Downstream 100 bases:

>100_bases
AAAATTTTAAGCATAACTCACAATCTTCTATATAATTACATTAAGATGTATAAGACGTATTTATTTCTAAATATTAACTT
ATTATATAATGTTATTCTAT

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 639; Mature: 639

Protein sequence:

>639_residues
MEDYITSLNEDQKKAVTNINGPILILAGAGTGKTRTITSRIAYILNNNFALPNQILAVTFTNKAANEMLSRINELTCASN
IWLGTFHAIATKILRQHAEAVGLKSDFTIIGTDDQLQVIKTIVNDMHPEYASDAYKIILNKIQRWKDRGLVPTNISDTEL
NKPINTIALSTYNIYQERLKFLNCADFGDLLLYNIEIFTKQHNILSHYQEQFKYIMVDEYQDINTIQYLWLRLLAQKHKN
LCCVGDDDQSIYSWRGAEVGNILKFSDDFPNAKTIRLECNYRSTSNILEVATAIINNNKSRLGKKLWTTNQEGNKVNLMK
FWDSRIEAQYICEYIKNLHDYQFKETAILVRAGFQTRIFEEYFIKYNIPYRIIGSTRFYDRQEIRDIIAYLKITVNPQHD
IAFDRIINKPKRNVGASTLNKIYSYAKQYNTHFLDATKILIENNQLSEKTSRSLNNLLNKINSWKESLLSDSISNTVKMI
AYDSGYIDMLENEGESGLARIENIKELFSALLNFNDVNAFLEHISLVTEVDISNDDDNYTCIMTLHAAKGLEFPVVFLPG
WEEGVFPHEKSLQDRTGEALEEERRLAYVGITRAREQLFISCVAVRDINNWRQQMEISRFIKELPIEHIQVIKNISNYH

Sequences:

>Translated_639_residues
MEDYITSLNEDQKKAVTNINGPILILAGAGTGKTRTITSRIAYILNNNFALPNQILAVTFTNKAANEMLSRINELTCASN
IWLGTFHAIATKILRQHAEAVGLKSDFTIIGTDDQLQVIKTIVNDMHPEYASDAYKIILNKIQRWKDRGLVPTNISDTEL
NKPINTIALSTYNIYQERLKFLNCADFGDLLLYNIEIFTKQHNILSHYQEQFKYIMVDEYQDINTIQYLWLRLLAQKHKN
LCCVGDDDQSIYSWRGAEVGNILKFSDDFPNAKTIRLECNYRSTSNILEVATAIINNNKSRLGKKLWTTNQEGNKVNLMK
FWDSRIEAQYICEYIKNLHDYQFKETAILVRAGFQTRIFEEYFIKYNIPYRIIGSTRFYDRQEIRDIIAYLKITVNPQHD
IAFDRIINKPKRNVGASTLNKIYSYAKQYNTHFLDATKILIENNQLSEKTSRSLNNLLNKINSWKESLLSDSISNTVKMI
AYDSGYIDMLENEGESGLARIENIKELFSALLNFNDVNAFLEHISLVTEVDISNDDDNYTCIMTLHAAKGLEFPVVFLPG
WEEGVFPHEKSLQDRTGEALEEERRLAYVGITRAREQLFISCVAVRDINNWRQQMEISRFIKELPIEHIQVIKNISNYH
>Mature_639_residues
MEDYITSLNEDQKKAVTNINGPILILAGAGTGKTRTITSRIAYILNNNFALPNQILAVTFTNKAANEMLSRINELTCASN
IWLGTFHAIATKILRQHAEAVGLKSDFTIIGTDDQLQVIKTIVNDMHPEYASDAYKIILNKIQRWKDRGLVPTNISDTEL
NKPINTIALSTYNIYQERLKFLNCADFGDLLLYNIEIFTKQHNILSHYQEQFKYIMVDEYQDINTIQYLWLRLLAQKHKN
LCCVGDDDQSIYSWRGAEVGNILKFSDDFPNAKTIRLECNYRSTSNILEVATAIINNNKSRLGKKLWTTNQEGNKVNLMK
FWDSRIEAQYICEYIKNLHDYQFKETAILVRAGFQTRIFEEYFIKYNIPYRIIGSTRFYDRQEIRDIIAYLKITVNPQHD
IAFDRIINKPKRNVGASTLNKIYSYAKQYNTHFLDATKILIENNQLSEKTSRSLNNLLNKINSWKESLLSDSISNTVKMI
AYDSGYIDMLENEGESGLARIENIKELFSALLNFNDVNAFLEHISLVTEVDISNDDDNYTCIMTLHAAKGLEFPVVFLPG
WEEGVFPHEKSLQDRTGEALEEERRLAYVGITRAREQLFISCVAVRDINNWRQQMEISRFIKELPIEHIQVIKNISNYH

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=643, Percent_Identity=39.6578538102644, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI48994965, Length=638, Percent_Identity=33.8557993730408, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1787196, Length=389, Percent_Identity=28.7917737789203, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6322369, Length=458, Percent_Identity=31.2227074235808, Blast_Score=177, Evalue=4e-45,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 73845; Mature: 73845

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYITSLNEDQKKAVTNINGPILILAGAGTGKTRTITSRIAYILNNNFALPNQILAVTF
CCCHHHHCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEE
TNKAANEMLSRINELTCASNIWLGTFHAIATKILRQHAEAVGLKSDFTIIGTDDQLQVIK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
TIVNDMHPEYASDAYKIILNKIQRWKDRGLVPTNISDTELNKPINTIALSTYNIYQERLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHEEEHHHHHHHHHHH
FLNCADFGDLLLYNIEIFTKQHNILSHYQEQFKYIMVDEYQDINTIQYLWLRLLAQKHKN
HHCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCC
LCCVGDDDQSIYSWRGAEVGNILKFSDDFPNAKTIRLECNYRSTSNILEVATAIINNNKS
EEEECCCCCHHHEECCCCCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHH
RLGKKLWTTNQEGNKVNLMKFWDSRIEAQYICEYIKNLHDYQFKETAILVRAGFQTRIFE
HHHHHHHCCCCCCCEEEHEEHHHHHCCHHHHHHHHHHHHCCCHHHEEEEEECCCHHHHHH
EYFIKYNIPYRIIGSTRFYDRQEIRDIIAYLKITVNPQHDIAFDRIINKPKRNVGASTLN
HHHEEECCCEEEECCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCCCCCHHHHH
KIYSYAKQYNTHFLDATKILIENNQLSEKTSRSLNNLLNKINSWKESLLSDSISNTVKMI
HHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
AYDSGYIDMLENEGESGLARIENIKELFSALLNFNDVNAFLEHISLVTEVDISNDDDNYT
EECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCEE
CIMTLHAAKGLEFPVVFLPGWEEGVFPHEKSLQDRTGEALEEERRLAYVGITRAREQLFI
EEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHHHHCCEEEEEHHHHHHHHHH
SCVAVRDINNWRQQMEISRFIKELPIEHIQVIKNISNYH
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDYITSLNEDQKKAVTNINGPILILAGAGTGKTRTITSRIAYILNNNFALPNQILAVTF
CCCHHHHCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEE
TNKAANEMLSRINELTCASNIWLGTFHAIATKILRQHAEAVGLKSDFTIIGTDDQLQVIK
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHH
TIVNDMHPEYASDAYKIILNKIQRWKDRGLVPTNISDTELNKPINTIALSTYNIYQERLK
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCHHHEEEHHHHHHHHHHH
FLNCADFGDLLLYNIEIFTKQHNILSHYQEQFKYIMVDEYQDINTIQYLWLRLLAQKHKN
HHCCCCCCCEEEEEEEEEEHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHCCC
LCCVGDDDQSIYSWRGAEVGNILKFSDDFPNAKTIRLECNYRSTSNILEVATAIINNNKS
EEEECCCCCHHHEECCCCCCCEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCHH
RLGKKLWTTNQEGNKVNLMKFWDSRIEAQYICEYIKNLHDYQFKETAILVRAGFQTRIFE
HHHHHHHCCCCCCCEEEHEEHHHHHCCHHHHHHHHHHHHCCCHHHEEEEEECCCHHHHHH
EYFIKYNIPYRIIGSTRFYDRQEIRDIIAYLKITVNPQHDIAFDRIINKPKRNVGASTLN
HHHEEECCCEEEECCCCCCCHHHHHHHHHHHEEEECCCCCHHHHHHHCCCCCCCCHHHHH
KIYSYAKQYNTHFLDATKILIENNQLSEKTSRSLNNLLNKINSWKESLLSDSISNTVKMI
HHHHHHHHHCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
AYDSGYIDMLENEGESGLARIENIKELFSALLNFNDVNAFLEHISLVTEVDISNDDDNYT
EECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCEE
CIMTLHAAKGLEFPVVFLPGWEEGVFPHEKSLQDRTGEALEEERRLAYVGITRAREQLFI
EEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHHHHCCEEEEEHHHHHHHHHH
SCVAVRDINNWRQQMEISRFIKELPIEHIQVIKNISNYH
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA