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The map label for this gene is hemE [H]

Identifier: 58616732

GI number: 58616732

Start: 3141

End: 4148

Strand: Reverse

Name: hemE [H]

Synonym: ERGA_CDS_00050

Alternate gene names: 58616732

Gene position: 4148-3141 (Counterclockwise)

Preceding gene: 58616734

Following gene: 58616731

Centisome position: 0.28

GC content: 32.44

Gene sequence:

>1008_bases
ATGTTAAAAACAATAGAAAGCAAGGCAAGGCAAAAAAACATACCAATATGGTTTATGAGACAAGCAGGAAGGTACCTACC
AGAATATCAAAAAATTGCAAAAAACGCCCCCAGCTTTTTAGAAATGTGCTACAATCCAGAAATAGTCAAAGAAATCACCC
TACAACCGATAAAACGTTTCAACTTAGATGCTGCAATAATATTTTCAGACATCCTTGTAATACCAGATGCTTTAGGATGC
AAAGTCACCTTCACAAAAGACAAAGGACCTGAACTAAAAGAAATATCAAGCTACCAAGAGATAAACAACATTTCAAACAG
CGAAATACTTTCACATCTTAGCAATGTTTTTCAAAGCATTAAAGAAGTAAGACAGTGCCTACATAAAGATAAAGCACTAA
TAGGATTTGCAGGAGGACCGTGGACTGTAGCTACCTACATGATAGGAAGAGATAAAAATTTCTCAAAAATAAAAGAAATG
TGTTACATTAAAAATAGAAACTTAGAAAAAATTATAGATAAGATCACAGAAGCAACAATCTCATACTTAATAAAACAAAT
AGAAAGTGGTGTAAATGTGCTACAGATCTTTGACAGTAATGCAGGAGTTTTATCATGTGAAGAGTTTGAAAGATGGATAA
TAAACCCTACAAAGGAAATAATATCAAGTGTAAGAAAAACATATCCAGATTTTCCGTTTATAGGCTTTCCCAAAGGAGCA
GGAGTATTATATAAAAAGTTTACACAAGAAACAAATGTATCAGTTACAAGTATAGATTACAGTGTTCCAATGTCTTGGGC
AAAAGAGAACATACCCTCAATAATACAAGGAAATATAGATCCATACTTACTAGCATATGATAAAGAAGGTGCTATTTCTC
AAGCAAAAAAAATAATTAACATAATGAAAAAAGAACCACTTATATTCAACCTAGGGCATGGAATCATTCCAAGCACTCCT
GTAGAAAATGTACAGGCTCTAGTAGAATTCGTTAAATCTATAACTTAA

Upstream 100 bases:

>100_bases
TGTACTTGCAAAAACAAGTTTTATCAACATAATTCACAGGGATCAACTATAACAACTATCTATAAGGATACTATAATATA
AATTCTACAGGAGACACATA

Downstream 100 bases:

>100_bases
TATACTATTAATATCTTAATGATAAAATATAAACTTGACAATGTACTGCCTTAACTATAAAAACTTTATAGTACTAATTT
GCTAGGGATTTGGAATGAAA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MLKTIESKARQKNIPIWFMRQAGRYLPEYQKIAKNAPSFLEMCYNPEIVKEITLQPIKRFNLDAAIIFSDILVIPDALGC
KVTFTKDKGPELKEISSYQEINNISNSEILSHLSNVFQSIKEVRQCLHKDKALIGFAGGPWTVATYMIGRDKNFSKIKEM
CYIKNRNLEKIIDKITEATISYLIKQIESGVNVLQIFDSNAGVLSCEEFERWIINPTKEIISSVRKTYPDFPFIGFPKGA
GVLYKKFTQETNVSVTSIDYSVPMSWAKENIPSIIQGNIDPYLLAYDKEGAISQAKKIINIMKKEPLIFNLGHGIIPSTP
VENVQALVEFVKSIT

Sequences:

>Translated_335_residues
MLKTIESKARQKNIPIWFMRQAGRYLPEYQKIAKNAPSFLEMCYNPEIVKEITLQPIKRFNLDAAIIFSDILVIPDALGC
KVTFTKDKGPELKEISSYQEINNISNSEILSHLSNVFQSIKEVRQCLHKDKALIGFAGGPWTVATYMIGRDKNFSKIKEM
CYIKNRNLEKIIDKITEATISYLIKQIESGVNVLQIFDSNAGVLSCEEFERWIINPTKEIISSVRKTYPDFPFIGFPKGA
GVLYKKFTQETNVSVTSIDYSVPMSWAKENIPSIIQGNIDPYLLAYDKEGAISQAKKIINIMKKEPLIFNLGHGIIPSTP
VENVQALVEFVKSIT
>Mature_335_residues
MLKTIESKARQKNIPIWFMRQAGRYLPEYQKIAKNAPSFLEMCYNPEIVKEITLQPIKRFNLDAAIIFSDILVIPDALGC
KVTFTKDKGPELKEISSYQEINNISNSEILSHLSNVFQSIKEVRQCLHKDKALIGFAGGPWTVATYMIGRDKNFSKIKEM
CYIKNRNLEKIIDKITEATISYLIKQIESGVNVLQIFDSNAGVLSCEEFERWIINPTKEIISSVRKTYPDFPFIGFPKGA
GVLYKKFTQETNVSVTSIDYSVPMSWAKENIPSIIQGNIDPYLLAYDKEGAISQAKKIINIMKKEPLIFNLGHGIIPSTP
VENVQALVEFVKSIT

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=330, Percent_Identity=36.969696969697, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI2367337, Length=330, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320252, Length=320, Percent_Identity=34.6875, Blast_Score=172, Evalue=6e-44,
Organism=Drosophila melanogaster, GI19921920, Length=329, Percent_Identity=37.6899696048632, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330099, Length=329, Percent_Identity=37.6899696048632, Blast_Score=209, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37985; Mature: 37985

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00906 UROD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKTIESKARQKNIPIWFMRQAGRYLPEYQKIAKNAPSFLEMCYNPEIVKEITLQPIKRF
CCCCHHHHHHHCCCCEEEEHHHCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHH
NLDAAIIFSDILVIPDALGCKVTFTKDKGPELKEISSYQEINNISNSEILSHLSNVFQSI
CCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KEVRQCLHKDKALIGFAGGPWTVATYMIGRDKNFSKIKEMCYIKNRNLEKIIDKITEATI
HHHHHHHHCCCEEEEECCCCCEEHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SYLIKQIESGVNVLQIFDSNAGVLSCEEFERWIINPTKEIISSVRKTYPDFPFIGFPKGA
HHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GVLYKKFTQETNVSVTSIDYSVPMSWAKENIPSIIQGNIDPYLLAYDKEGAISQAKKIIN
HHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCHHHCCCCCCEEEEECCCCHHHHHHHHHH
IMKKEPLIFNLGHGIIPSTPVENVQALVEFVKSIT
HHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKTIESKARQKNIPIWFMRQAGRYLPEYQKIAKNAPSFLEMCYNPEIVKEITLQPIKRF
CCCCHHHHHHHCCCCEEEEHHHCCCCHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHH
NLDAAIIFSDILVIPDALGCKVTFTKDKGPELKEISSYQEINNISNSEILSHLSNVFQSI
CCCHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
KEVRQCLHKDKALIGFAGGPWTVATYMIGRDKNFSKIKEMCYIKNRNLEKIIDKITEATI
HHHHHHHHCCCEEEEECCCCCEEHEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
SYLIKQIESGVNVLQIFDSNAGVLSCEEFERWIINPTKEIISSVRKTYPDFPFIGFPKGA
HHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GVLYKKFTQETNVSVTSIDYSVPMSWAKENIPSIIQGNIDPYLLAYDKEGAISQAKKIIN
HHHHHHHHHHCCCEEEEEECCCCHHHHHHCCCHHHCCCCCCEEEEECCCCHHHHHHHHHH
IMKKEPLIFNLGHGIIPSTPVENVQALVEFVKSIT
HHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA