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The map label for this gene is actII-3 [H]

Identifier: 56965818

GI number: 56965818

Start: 4233790

End: 4235850

Strand: Direct

Name: actII-3 [H]

Synonym: ABC4060

Alternate gene names: 56965818

Gene position: 4233790-4235850 (Clockwise)

Preceding gene: 56965813

Following gene: 56965819

Centisome position: 98.37

GC content: 47.06

Gene sequence:

>2061_bases
TTGTTCGTCGATACCATCATAAAGCATAAAAAAGGCATTATCCTTTTATTTGCCATCACTGCCCTTTTCGCAGCGGTAGC
TCAATTTTTTGTATCGACCAACTACAATATGGTTGATTACTTGCCAGATGATGCTCCTTCCACTGAAGGCTTGGCGTTAA
TGGAGGAAGAGTTTCGCTCAGCAATGCCGAATACAAACGTGCTCATTCATGACGTCTCCATTCAAGAAGCGATTCGTTAT
AAAGAGCAACTAGCAAGCATTGATGGCGTGAGCGACGTATCGTGGCTCGATGACGTGTTTGATATTCGGATTCCTCTCGA
AATGGCGGACACAAGCTTAATTGAAACATATTACAAAGACCGTGACGCCTTGTTTTCGGTAACAATTGACAGCGGTGCCG
AAGTAGCGGCGACAGATGCGATTTATTCATTGATTGGCGAAGAAAACGCCGTTACAGGGGAAGCGGTTAACACAGCTACG
TCCCAGAAAATGACTGGTTCCGAGACGCTCTATGCTGCAGCGTTGCTCGTTCCAATTATTATCATTATTTTGGTGTTATC
GACCAAGTCATGGGTCGAGCCATTGTTTTTCCTAACGGCGATCGGCGTTTCCGTCCTCATCAATTTAGGAACGAACATTT
TTTTAGGGGAAGTTTCATTCGTGACACAAGCAGTGGCGCCTATTTTACAGCTCGCTGTTTCCCTTGATTATGCCATATTC
CTTTTACATACCTTTTCAGACGAGCTGGACCAACATCAATCGCCGAAAGAAGCGATGGCAAAAGCGATGCGCAAATCGTT
TCCGGTTATCTTTGTCAGTGCCTTAACGACATTTTTTGGATTCATGTCGCTCATGCTAATGGACTTTGGAATTGGCGTCG
ATTTAGGGTTTAACCTCGTCAAAGGAATTGTGTTCAGCTTTATATCAGTCGTCGTGTTTTTGCCTGCGTTGACGCTGACT
TGTTACAAATGGATCGAAAAAACGACGCATCGAAGCTTGGTGCCGAGCTTCAAAGGCAGCGGGGCCAAGCTGCTTAAGCT
GCGGATTCCCACTCTCGTCCTTGTCCTCCTGCTGCTCGTTCCAAGTTTTTTGGCGCAAAGCAGCACCACCTTTCTTTATG
GGCTTGGGGACTTGCCTGAACAGACACGCGCTGGCGCCGATGCGAAACAAGTCGAGGAAACGTTCGGGCAATCAACGCCG
ATTGTCTTGCTCGTCCCTAATGACGACATCGCTAAAGAAGAAAAGCTTGTCCAAGAGTTGGAACAGATTCCCTCTGTCGA
GTCCGTGCTTGCCTATGCCAACATGGTCGGGGCAGCGATCCCTTCTGATTTTCTCGATGATGAATTGACGAGCGATTTCC
ATTCGGAAAACTACAGCCGCATTACCGTCTATACATCTGCCGGCGTCGAGGGGGATCTCCCATTTGCGCTCGTGGAACAG
ATACGTGAAATCGCGCAAAACTATTACGGCGATGCGTTTTATACATTAGGGGAAAGCGCGACGCTGTATGATATGAAACA
AACAATCAGCAAAGACAACCAGCTCGTTAACATCGTGACGATCACCACGATTGCCGTTGTTCTTATGTTTATGTTCCGGT
CGATTTCGATACCGATTATATTGTTGCTCACCATTCAGGCGGCTGTCTGGCTCAACCTGTCGGTGCCTTATTTTACAAAC
GAGCCACTCGTGTTTGTCGGCTATTTGATCGTCAGTACCGTCCAGTTAGCCGCAACGATCGATTATGCGATTTTGCTGAT
GGAAACGTATAAACATCACCGCCAGATGATGCCGTCCTTTGCAGCAATGAAGCGGGCGCTTGATGAAAAATTGTTTCCAA
TTGCTGTTTCTGCGGCGATTTTATCAAGTGTTGGGTTCATTTTATGGTTTACGTCAAGCAATCCCACTGTCTCATCGATT
GGATTATTGCTCGGCAGGGGGGCTGCCCTCGCCTTCCTATTGGTCATATTATTCCTTCCGGCGTTCCTTTTGATCGCCGA
CCGCTTGATCGAGAAAACAACGCATCGGGCCAACTTTTACAAGGAGGAGGACTCATTATGA

Upstream 100 bases:

>100_bases
CACAACAGATTATAACCGACTGTGTGTTGTTTGCCCAACACTGTGTCGTTATAATATGAAATGCATTGAAACGATTGTCA
ACAAAAGAGGTGATACGCGC

Downstream 100 bases:

>100_bases
CGTTACGAAAAATGGCAACTGCGTGTACGATCGCTGTACTCTGCATCCCTTCGATTTCTTTTCAAGCAGAGGCAAACGGA
CACGGGGAAGTGGCTGCCAA

Product: RND superfamily drug efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MFVDTIIKHKKGIILLFAITALFAAVAQFFVSTNYNMVDYLPDDAPSTEGLALMEEEFRSAMPNTNVLIHDVSIQEAIRY
KEQLASIDGVSDVSWLDDVFDIRIPLEMADTSLIETYYKDRDALFSVTIDSGAEVAATDAIYSLIGEENAVTGEAVNTAT
SQKMTGSETLYAAALLVPIIIIILVLSTKSWVEPLFFLTAIGVSVLINLGTNIFLGEVSFVTQAVAPILQLAVSLDYAIF
LLHTFSDELDQHQSPKEAMAKAMRKSFPVIFVSALTTFFGFMSLMLMDFGIGVDLGFNLVKGIVFSFISVVVFLPALTLT
CYKWIEKTTHRSLVPSFKGSGAKLLKLRIPTLVLVLLLLVPSFLAQSSTTFLYGLGDLPEQTRAGADAKQVEETFGQSTP
IVLLVPNDDIAKEEKLVQELEQIPSVESVLAYANMVGAAIPSDFLDDELTSDFHSENYSRITVYTSAGVEGDLPFALVEQ
IREIAQNYYGDAFYTLGESATLYDMKQTISKDNQLVNIVTITTIAVVLMFMFRSISIPIILLLTIQAAVWLNLSVPYFTN
EPLVFVGYLIVSTVQLAATIDYAILLMETYKHHRQMMPSFAAMKRALDEKLFPIAVSAAILSSVGFILWFTSSNPTVSSI
GLLLGRGAALAFLLVILFLPAFLLIADRLIEKTTHRANFYKEEDSL

Sequences:

>Translated_686_residues
MFVDTIIKHKKGIILLFAITALFAAVAQFFVSTNYNMVDYLPDDAPSTEGLALMEEEFRSAMPNTNVLIHDVSIQEAIRY
KEQLASIDGVSDVSWLDDVFDIRIPLEMADTSLIETYYKDRDALFSVTIDSGAEVAATDAIYSLIGEENAVTGEAVNTAT
SQKMTGSETLYAAALLVPIIIIILVLSTKSWVEPLFFLTAIGVSVLINLGTNIFLGEVSFVTQAVAPILQLAVSLDYAIF
LLHTFSDELDQHQSPKEAMAKAMRKSFPVIFVSALTTFFGFMSLMLMDFGIGVDLGFNLVKGIVFSFISVVVFLPALTLT
CYKWIEKTTHRSLVPSFKGSGAKLLKLRIPTLVLVLLLLVPSFLAQSSTTFLYGLGDLPEQTRAGADAKQVEETFGQSTP
IVLLVPNDDIAKEEKLVQELEQIPSVESVLAYANMVGAAIPSDFLDDELTSDFHSENYSRITVYTSAGVEGDLPFALVEQ
IREIAQNYYGDAFYTLGESATLYDMKQTISKDNQLVNIVTITTIAVVLMFMFRSISIPIILLLTIQAAVWLNLSVPYFTN
EPLVFVGYLIVSTVQLAATIDYAILLMETYKHHRQMMPSFAAMKRALDEKLFPIAVSAAILSSVGFILWFTSSNPTVSSI
GLLLGRGAALAFLLVILFLPAFLLIADRLIEKTTHRANFYKEEDSL
>Mature_686_residues
MFVDTIIKHKKGIILLFAITALFAAVAQFFVSTNYNMVDYLPDDAPSTEGLALMEEEFRSAMPNTNVLIHDVSIQEAIRY
KEQLASIDGVSDVSWLDDVFDIRIPLEMADTSLIETYYKDRDALFSVTIDSGAEVAATDAIYSLIGEENAVTGEAVNTAT
SQKMTGSETLYAAALLVPIIIIILVLSTKSWVEPLFFLTAIGVSVLINLGTNIFLGEVSFVTQAVAPILQLAVSLDYAIF
LLHTFSDELDQHQSPKEAMAKAMRKSFPVIFVSALTTFFGFMSLMLMDFGIGVDLGFNLVKGIVFSFISVVVFLPALTLT
CYKWIEKTTHRSLVPSFKGSGAKLLKLRIPTLVLVLLLLVPSFLAQSSTTFLYGLGDLPEQTRAGADAKQVEETFGQSTP
IVLLVPNDDIAKEEKLVQELEQIPSVESVLAYANMVGAAIPSDFLDDELTSDFHSENYSRITVYTSAGVEGDLPFALVEQ
IREIAQNYYGDAFYTLGESATLYDMKQTISKDNQLVNIVTITTIAVVLMFMFRSISIPIILLLTIQAAVWLNLSVPYFTN
EPLVFVGYLIVSTVQLAATIDYAILLMETYKHHRQMMPSFAAMKRALDEKLFPIAVSAAILSSVGFILWFTSSNPTVSSI
GLLLGRGAALAFLLVILFLPAFLLIADRLIEKTTHRANFYKEEDSL

Specific function: Unknown

COG id: COG1033

COG function: function code R; Predicted exporters of the RND superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mmpL family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004707
- InterPro:   IPR004869
- InterPro:   IPR000731 [H]

Pfam domain/function: PF03176 MMPL [H]

EC number: NA

Molecular weight: Translated: 75540; Mature: 75540

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: PS50156 SSD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVDTIIKHKKGIILLFAITALFAAVAQFFVSTNYNMVDYLPDDAPSTEGLALMEEEFRS
CCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
AMPNTNVLIHDVSIQEAIRYKEQLASIDGVSDVSWLDDVFDIRIPLEMADTSLIETYYKD
HCCCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHCC
RDALFSVTIDSGAEVAATDAIYSLIGEENAVTGEAVNTATSQKMTGSETLYAAALLVPII
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
IIILVLSTKSWVEPLFFLTAIGVSVLINLGTNIFLGEVSFVTQAVAPILQLAVSLDYAIF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LLHTFSDELDQHQSPKEAMAKAMRKSFPVIFVSALTTFFGFMSLMLMDFGIGVDLGFNLV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KGIVFSFISVVVFLPALTLTCYKWIEKTTHRSLVPSFKGSGAKLLKLRIPTLVLVLLLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHH
PSFLAQSSTTFLYGLGDLPEQTRAGADAKQVEETFGQSTPIVLLVPNDDIAKEEKLVQEL
HHHHHCCCCEEEEECCCCCHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
EQIPSVESVLAYANMVGAAIPSDFLDDELTSDFHSENYSRITVYTSAGVEGDLPFALVEQ
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHH
IREIAQNYYGDAFYTLGESATLYDMKQTISKDNQLVNIVTITTIAVVLMFMFRSISIPII
HHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCHHHH
LLLTIQAAVWLNLSVPYFTNEPLVFVGYLIVSTVQLAATIDYAILLMETYKHHRQMMPSF
HHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
AAMKRALDEKLFPIAVSAAILSSVGFILWFTSSNPTVSSIGLLLGRGAALAFLLVILFLP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHH
AFLLIADRLIEKTTHRANFYKEEDSL
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFVDTIIKHKKGIILLFAITALFAAVAQFFVSTNYNMVDYLPDDAPSTEGLALMEEEFRS
CCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHH
AMPNTNVLIHDVSIQEAIRYKEQLASIDGVSDVSWLDDVFDIRIPLEMADTSLIETYYKD
HCCCCCEEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEECHHHHHHHHHHHHHCC
RDALFSVTIDSGAEVAATDAIYSLIGEENAVTGEAVNTATSQKMTGSETLYAAALLVPII
CCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
IIILVLSTKSWVEPLFFLTAIGVSVLINLGTNIFLGEVSFVTQAVAPILQLAVSLDYAIF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
LLHTFSDELDQHQSPKEAMAKAMRKSFPVIFVSALTTFFGFMSLMLMDFGIGVDLGFNLV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KGIVFSFISVVVFLPALTLTCYKWIEKTTHRSLVPSFKGSGAKLLKLRIPTLVLVLLLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHH
PSFLAQSSTTFLYGLGDLPEQTRAGADAKQVEETFGQSTPIVLLVPNDDIAKEEKLVQEL
HHHHHCCCCEEEEECCCCCHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
EQIPSVESVLAYANMVGAAIPSDFLDDELTSDFHSENYSRITVYTSAGVEGDLPFALVEQ
HHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHH
IREIAQNYYGDAFYTLGESATLYDMKQTISKDNQLVNIVTITTIAVVLMFMFRSISIPII
HHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCHHHH
LLLTIQAAVWLNLSVPYFTNEPLVFVGYLIVSTVQLAATIDYAILLMETYKHHRQMMPSF
HHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
AAMKRALDEKLFPIAVSAAILSSVGFILWFTSSNPTVSSIGLLLGRGAALAFLLVILFLP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHH
AFLLIADRLIEKTTHRANFYKEEDSL
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1878971; 12000953 [H]