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The map label for this gene is dapE [H]

Identifier: 56965274

GI number: 56965274

Start: 3648568

End: 3649650

Strand: Direct

Name: dapE [H]

Synonym: ABC3512

Alternate gene names: 56965274

Gene position: 3648568-3649650 (Clockwise)

Preceding gene: 56965273

Following gene: 56965284

Centisome position: 84.77

GC content: 48.48

Gene sequence:

>1083_bases
ATGGGGGACCCAATCCCGTTGCTAAAGGATTTAATTCGCATAGATAGTTCAACCAAAGCCGGAGTCAACAAAGCGATGGC
TTTTTGCGAAGAGTGGCTGAACGACAAAGGGCTGCCAGTCGAACGGCTTGTTAACAACGGTTATTCTATGCTTGTCTCTA
GCATTGGAAGTGGGAGCAACACCATTGTGCTCAATGGCCATATTGACGTGATTGAAGGCAGCCGATCCCAGTTTACACCA
TACACAAAGGAAGGAAAAATATATGGACGCGGCTCGGCGGATATGAAAGCCGGTTTAGCCGCGATGATGGAAACAATGGC
AGAGTTAAACGGCGTGCCTCTCCCTTGGCGCGTCCAACTTCAAATCGTCCCTGATGAAGAAACAGGAGGCCTTTACGGTA
CCAACTATTTAGTAGAACAAGGGCACCGAGGCGATTTCATCATCTGCGGCGAACCCACAAACATGGGAATCGCCATTCAG
TCAAAGGGCGTCTTGCAGGTTGATATTCACATCAAGGGAGAACCTGCGCACGGCAGCCGTCCTTGGGAAGGCAATAACGC
CATATTAAAAGCACATGCACTCTATGAAGCCATTCTTGAATTGCCGTTCGCCCAAGAGGTAGCGCCTCCCATGTTCAAAG
AACCGTCTATTAACCTTGCAAAGTTACAGGGAGGCACCGTCTACAACAAAGTACCTGACCAATGCGATATGTCACTGGAC
ATCCGCTATTTGCCAGACCAATCGCCTAGCGAGATTTTGCGGCAAATTAAAGGAATCACGGACGGCGTCGTACGCACACA
TATTTGCAATAGCCCTGTCAAAACAAAAGCAGACAATCCATTTGTCCAAGCGCTCGCGGATTCGTTAGTGGCACAAACAC
AATTGGAAAAGGCGACACTTTACGGGCAACACGGCTCCAACGATGGGCAATTTTTTACAAAGTACGGCGGAAATGCCGTT
GAATTCGGGCCCGTTGGCTATGACTGGCATGGCGACAATGAAATGGTGTATACAGATTCAGTTAGGCAGTACCAAGCCGT
TTTGATCGATTTCCTAAAAAACGGCCAATCTGACTTTGTGTAG

Upstream 100 bases:

>100_bases
CTCGCCATGACATCGTTGTCCCAATTGAGAAGACATTTTCTGAACTGCATCCAAGTCGGTGATCGAGTATCATACTATTT
GCGAAGTTAGGAGGAAAAAC

Downstream 100 bases:

>100_bases
TAACAGCAACGGCGAGCGGTTTATTTGAAGGTTGAGCAAGCAGCACAACGCTGCTTGCTACTTTCTATTTAAAATACCTA
AATACGCCTGCCAAGGCCCT

Product: succinyl-diaminopimelate desuccinylase

Products: NA

Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MGDPIPLLKDLIRIDSSTKAGVNKAMAFCEEWLNDKGLPVERLVNNGYSMLVSSIGSGSNTIVLNGHIDVIEGSRSQFTP
YTKEGKIYGRGSADMKAGLAAMMETMAELNGVPLPWRVQLQIVPDEETGGLYGTNYLVEQGHRGDFIICGEPTNMGIAIQ
SKGVLQVDIHIKGEPAHGSRPWEGNNAILKAHALYEAILELPFAQEVAPPMFKEPSINLAKLQGGTVYNKVPDQCDMSLD
IRYLPDQSPSEILRQIKGITDGVVRTHICNSPVKTKADNPFVQALADSLVAQTQLEKATLYGQHGSNDGQFFTKYGGNAV
EFGPVGYDWHGDNEMVYTDSVRQYQAVLIDFLKNGQSDFV

Sequences:

>Translated_360_residues
MGDPIPLLKDLIRIDSSTKAGVNKAMAFCEEWLNDKGLPVERLVNNGYSMLVSSIGSGSNTIVLNGHIDVIEGSRSQFTP
YTKEGKIYGRGSADMKAGLAAMMETMAELNGVPLPWRVQLQIVPDEETGGLYGTNYLVEQGHRGDFIICGEPTNMGIAIQ
SKGVLQVDIHIKGEPAHGSRPWEGNNAILKAHALYEAILELPFAQEVAPPMFKEPSINLAKLQGGTVYNKVPDQCDMSLD
IRYLPDQSPSEILRQIKGITDGVVRTHICNSPVKTKADNPFVQALADSLVAQTQLEKATLYGQHGSNDGQFFTKYGGNAV
EFGPVGYDWHGDNEMVYTDSVRQYQAVLIDFLKNGQSDFV
>Mature_359_residues
GDPIPLLKDLIRIDSSTKAGVNKAMAFCEEWLNDKGLPVERLVNNGYSMLVSSIGSGSNTIVLNGHIDVIEGSRSQFTPY
TKEGKIYGRGSADMKAGLAAMMETMAELNGVPLPWRVQLQIVPDEETGGLYGTNYLVEQGHRGDFIICGEPTNMGIAIQS
KGVLQVDIHIKGEPAHGSRPWEGNNAILKAHALYEAILELPFAQEVAPPMFKEPSINLAKLQGGTVYNKVPDQCDMSLDI
RYLPDQSPSEILRQIKGITDGVVRTHICNSPVKTKADNPFVQALADSLVAQTQLEKATLYGQHGSNDGQFFTKYGGNAVE
FGPVGYDWHGDNEMVYTDSVRQYQAVLIDFLKNGQSDFV

Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=270, Percent_Identity=30.3703703703704, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1790395, Length=255, Percent_Identity=30.1960784313725, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI1788816, Length=374, Percent_Identity=26.7379679144385, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1789236, Length=221, Percent_Identity=25.3393665158371, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17551016, Length=308, Percent_Identity=22.4025974025974, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005941
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 39349; Mature: 39218

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDPIPLLKDLIRIDSSTKAGVNKAMAFCEEWLNDKGLPVERLVNNGYSMLVSSIGSGSN
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCCCC
TIVLNGHIDVIEGSRSQFTPYTKEGKIYGRGSADMKAGLAAMMETMAELNGVPLPWRVQL
EEEEECCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
QIVPDEETGGLYGTNYLVEQGHRGDFIICGEPTNMGIAIQSKGVLQVDIHIKGEPAHGSR
EEECCCCCCCEECCCHHEECCCCCCEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCC
PWEGNNAILKAHALYEAILELPFAQEVAPPMFKEPSINLAKLQGGTVYNKVPDQCDMSLD
CCCCCCCEEEHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCEEECCCCCCCCCEEE
IRYLPDQSPSEILRQIKGITDGVVRTHICNSPVKTKADNPFVQALADSLVAQTQLEKATL
EEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHE
YGQHGSNDGQFFTKYGGNAVEFGPVGYDWHGDNEMVYTDSVRQYQAVLIDFLKNGQSDFV
ECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GDPIPLLKDLIRIDSSTKAGVNKAMAFCEEWLNDKGLPVERLVNNGYSMLVSSIGSGSN
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHCCCCCC
TIVLNGHIDVIEGSRSQFTPYTKEGKIYGRGSADMKAGLAAMMETMAELNGVPLPWRVQL
EEEEECCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEE
QIVPDEETGGLYGTNYLVEQGHRGDFIICGEPTNMGIAIQSKGVLQVDIHIKGEPAHGSR
EEECCCCCCCEECCCHHEECCCCCCEEEECCCCCCEEEEECCCEEEEEEEEECCCCCCCC
PWEGNNAILKAHALYEAILELPFAQEVAPPMFKEPSINLAKLQGGTVYNKVPDQCDMSLD
CCCCCCCEEEHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEECCCEEECCCCCCCCCEEE
IRYLPDQSPSEILRQIKGITDGVVRTHICNSPVKTKADNPFVQALADSLVAQTQLEKATL
EEECCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHE
YGQHGSNDGQFFTKYGGNAVEFGPVGYDWHGDNEMVYTDSVRQYQAVLIDFLKNGQSDFV
ECCCCCCCCCEEEECCCCEEEECCCCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA