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The map label for this gene is manR [H]

Identifier: 56965263

GI number: 56965263

Start: 3637640

End: 3639760

Strand: Direct

Name: manR [H]

Synonym: ABC3501

Alternate gene names: 56965263

Gene position: 3637640-3639760 (Clockwise)

Preceding gene: 56965262

Following gene: 56965264

Centisome position: 84.52

GC content: 45.4

Gene sequence:

>2121_bases
ATGAAACGCAAACATGCAGAAATCTTCCAAGAAATTGTCAGGCATAAGGGCTACGTGCCCGTTAAATCGCTTTCCGAAAC
ATTCCAAGTCTCTGCGCGAACAATCCGTTATGCCCTGGAGGAAATCGATGATTATTTAAGGGATCATCAGCAGCCGCCGC
TTAAGCGCAATCGGAAAAAAGGCGTTTATTATGACTGCGATCAAGAGGTGCTCCACAAGCTTCTTGGTTCTGACACACTC
CATTTTCCCGATGCTGCCGACCGCGAAGCTTTTCTCGTATTCGCTTTCTTTTACGCCGAGGAGAAAGTGACTGTCCCTTC
GATTTGCGAGCACTTGCTAGTGAGTAAAAGCACAGTAGACAAAGACATTCAGCGGCTGCGGACGGAGCTTCTTGCTGACA
ACTTGCGAATAGACAGTTTGCCTAAAGAAGGATTTGCCGTCGTCGGCTCAGAGTTCGCGAAGCGGCGCTGGCTTTTCCGG
TTTTTGAAACGGGCCTGCCGTAATAGAGGCTTGGACATGTTGAAACAAAGCGAAGCAGCCACATTCTTTGAAGATTATTG
CTGTAAATTGGTGGAAGCCACTGCGTTGGAACAGACTTTGGCATGGATTCGGACAATCGAACAGCAAAAGAATGGCCGTT
TTACGTACGAAACCCATTTAGAAATTGGCTTGTATGCATTGCTAGCGCTTAAGCGCATCAAAATGGGCTACTTATTGACA
GAGAAGGTAATGGTCCCAGAACAGCTGGACAAACAAGCATTTGCCCTTGCCCAAACATTTGATTTTCAAAAACCGGTAAC
AGAGCTGAACACCGAAATTTACGTATTATCGCTATTTCTTTCGACTGCTAAGGAAGAGCAATTCTTATTCAAAATGGAAG
GAAATTGGGGGCAAATCCAAGTCGCTGTTATGGACTTTGTGCACTCCATCACAAAGCAGACAGGACTACCATTTGTAAAC
GACCAAGAATATTTTTCAAGTATTTATGCCCATATCCAAACAATGGCAAGACGACTTAAAAACGAGCTGCCGATTGAAAA
CCCGATTGCCGACGTCATTGTCAAACAATACCCTGATTTATTTGCGGCATGCCGCATGGCAGGAAATGAATTGGAACGAA
CGCTGCAACTAACGATTCCAATCGATGAAATTGCCTATTTAACGATGCATACTTGCGTCGCCTCTGAACGACTGAAACGG
CAAACGCTTGTGTACCGGACGGTCATTATTTGCGGTCATGGCATTACAAATGCCCGTTTAATCGAAGAAAGCTTGTACGC
GCGCTTTTCTTCCATTGAAGTATTAGGCACATTATCCCGTTATGAAGTCGATGTCATCCAAAAATTGCAAGTCGACTTTG
TCTTAACGACATTGCCCCTTTCCATCAAAGGTGTGCCTTGCTTGCAAGTGTCCCCGTTTTTCAAGGATGAGGACACAGCC
TTAATCCAAACAACGATTGCGCAAATCGCGAAATCAAAACAAAGGCAACGGCAGAAGCACGGAGCAACGAATGAAGACTT
CTTCCGTTCGATTGTGGAAATTGCAAAAGCAAACAGCAAATCGTTCATGCTTAAACCGTTTATGGAAGAATTAGCGTCTC
TATTTAAAAAACATCAGTTGCCAGTCTACGAAGGAGTGATCCAGCCATTGTTAGCCGAGCTAATGAGCGAAGACCATATT
GAACTAAACGTTCGCGCCGCCAATTGGCAAGAAGCCATTTATGCGGCCGCTAAACCTTTAGAAAGAAGCGGCGCCATTAC
AAAAAATTACGCAGAAGCGATGATCGCCTCTGTGCATGAATACGGGCCTTATATTGTCCTTGCTCCAGGGGTTGCGATCG
CCCATGCCCGGCCAGAAGACGGCGTAAATGAGCTAAGTGTTAGTTTTATCCAGCTAGCAGAGCCGATACCATTCGGCAAT
CCAGATAACGACCCGGTATTTCTTGTGATTTGCTTGGCCGCTTCTGACAGTTTTTCACACTTAAAAGCGTTTCGTTCAAT
TGTGAAATTAATTAATGACGAACAGCGACTAGACGCAATAAAAGCCGCCACCTCCAAGCAATCGTTAACCAGAATCGTTC
TCAACGAAGAAGGGGAGAAAGCCTATGTCGACGGTCCGTAA

Upstream 100 bases:

>100_bases
CCGCCTTAGCCGCCTACTTCTTTTCCGCTTAAAATGGAAGAACTTTAAGCTTCAAATCGTGAAAGCGGTAACATATGATT
AAGCCAAAGGAGGGTGGCGA

Downstream 100 bases:

>100_bases
CATTGCTTTAATTACAAGCGGCGGCGATGCGCCAGGGCTAAATGGTGCCATTGCGGCAATTGCCCAAACGCCGGATGTTA
ACCTTTATTTCTATCATGGC

Product: hypothetical protein

Products: NA

Alternate protein names: Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 706; Mature: 706

Protein sequence:

>706_residues
MKRKHAEIFQEIVRHKGYVPVKSLSETFQVSARTIRYALEEIDDYLRDHQQPPLKRNRKKGVYYDCDQEVLHKLLGSDTL
HFPDAADREAFLVFAFFYAEEKVTVPSICEHLLVSKSTVDKDIQRLRTELLADNLRIDSLPKEGFAVVGSEFAKRRWLFR
FLKRACRNRGLDMLKQSEAATFFEDYCCKLVEATALEQTLAWIRTIEQQKNGRFTYETHLEIGLYALLALKRIKMGYLLT
EKVMVPEQLDKQAFALAQTFDFQKPVTELNTEIYVLSLFLSTAKEEQFLFKMEGNWGQIQVAVMDFVHSITKQTGLPFVN
DQEYFSSIYAHIQTMARRLKNELPIENPIADVIVKQYPDLFAACRMAGNELERTLQLTIPIDEIAYLTMHTCVASERLKR
QTLVYRTVIICGHGITNARLIEESLYARFSSIEVLGTLSRYEVDVIQKLQVDFVLTTLPLSIKGVPCLQVSPFFKDEDTA
LIQTTIAQIAKSKQRQRQKHGATNEDFFRSIVEIAKANSKSFMLKPFMEELASLFKKHQLPVYEGVIQPLLAELMSEDHI
ELNVRAANWQEAIYAAAKPLERSGAITKNYAEAMIASVHEYGPYIVLAPGVAIAHARPEDGVNELSVSFIQLAEPIPFGN
PDNDPVFLVICLAASDSFSHLKAFRSIVKLINDEQRLDAIKAATSKQSLTRIVLNEEGEKAYVDGP

Sequences:

>Translated_706_residues
MKRKHAEIFQEIVRHKGYVPVKSLSETFQVSARTIRYALEEIDDYLRDHQQPPLKRNRKKGVYYDCDQEVLHKLLGSDTL
HFPDAADREAFLVFAFFYAEEKVTVPSICEHLLVSKSTVDKDIQRLRTELLADNLRIDSLPKEGFAVVGSEFAKRRWLFR
FLKRACRNRGLDMLKQSEAATFFEDYCCKLVEATALEQTLAWIRTIEQQKNGRFTYETHLEIGLYALLALKRIKMGYLLT
EKVMVPEQLDKQAFALAQTFDFQKPVTELNTEIYVLSLFLSTAKEEQFLFKMEGNWGQIQVAVMDFVHSITKQTGLPFVN
DQEYFSSIYAHIQTMARRLKNELPIENPIADVIVKQYPDLFAACRMAGNELERTLQLTIPIDEIAYLTMHTCVASERLKR
QTLVYRTVIICGHGITNARLIEESLYARFSSIEVLGTLSRYEVDVIQKLQVDFVLTTLPLSIKGVPCLQVSPFFKDEDTA
LIQTTIAQIAKSKQRQRQKHGATNEDFFRSIVEIAKANSKSFMLKPFMEELASLFKKHQLPVYEGVIQPLLAELMSEDHI
ELNVRAANWQEAIYAAAKPLERSGAITKNYAEAMIASVHEYGPYIVLAPGVAIAHARPEDGVNELSVSFIQLAEPIPFGN
PDNDPVFLVICLAASDSFSHLKAFRSIVKLINDEQRLDAIKAATSKQSLTRIVLNEEGEKAYVDGP
>Mature_706_residues
MKRKHAEIFQEIVRHKGYVPVKSLSETFQVSARTIRYALEEIDDYLRDHQQPPLKRNRKKGVYYDCDQEVLHKLLGSDTL
HFPDAADREAFLVFAFFYAEEKVTVPSICEHLLVSKSTVDKDIQRLRTELLADNLRIDSLPKEGFAVVGSEFAKRRWLFR
FLKRACRNRGLDMLKQSEAATFFEDYCCKLVEATALEQTLAWIRTIEQQKNGRFTYETHLEIGLYALLALKRIKMGYLLT
EKVMVPEQLDKQAFALAQTFDFQKPVTELNTEIYVLSLFLSTAKEEQFLFKMEGNWGQIQVAVMDFVHSITKQTGLPFVN
DQEYFSSIYAHIQTMARRLKNELPIENPIADVIVKQYPDLFAACRMAGNELERTLQLTIPIDEIAYLTMHTCVASERLKR
QTLVYRTVIICGHGITNARLIEESLYARFSSIEVLGTLSRYEVDVIQKLQVDFVLTTLPLSIKGVPCLQVSPFFKDEDTA
LIQTTIAQIAKSKQRQRQKHGATNEDFFRSIVEIAKANSKSFMLKPFMEELASLFKKHQLPVYEGVIQPLLAELMSEDHI
ELNVRAANWQEAIYAAAKPLERSGAITKNYAEAMIASVHEYGPYIVLAPGVAIAHARPEDGVNELSVSFIQLAEPIPFGN
PDNDPVFLVICLAASDSFSHLKAFRSIVKLINDEQRLDAIKAATSKQSLTRIVLNEEGEKAYVDGP

Specific function: May regulate the expression of the mannose operon [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790755, Length=134, Percent_Identity=35.8208955223881, Blast_Score=109, Evalue=7e-25,
Organism=Escherichia coli, GI2367359, Length=141, Percent_Identity=34.0425531914894, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789302, Length=144, Percent_Identity=36.1111111111111, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF00359 PTS_EIIA_2 [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 80459; Mature: 80459

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKHAEIFQEIVRHKGYVPVKSLSETFQVSARTIRYALEEIDDYLRDHQQPPLKRNRKK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCC
GVYYDCDQEVLHKLLGSDTLHFPDAADREAFLVFAFFYAEEKVTVPSICEHLLVSKSTVD
CCEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KDIQRLRTELLADNLRIDSLPKEGFAVVGSEFAKRRWLFRFLKRACRNRGLDMLKQSEAA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TFFEDYCCKLVEATALEQTLAWIRTIEQQKNGRFTYETHLEIGLYALLALKRIKMGYLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
EKVMVPEQLDKQAFALAQTFDFQKPVTELNTEIYVLSLFLSTAKEEQFLFKMEGNWGQIQ
HHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCEEE
VAVMDFVHSITKQTGLPFVNDQEYFSSIYAHIQTMARRLKNELPIENPIADVIVKQYPDL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHH
FAACRMAGNELERTLQLTIPIDEIAYLTMHTCVASERLKRQTLVYRTVIICGHGITNARL
HHHHHHHHHHHHCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IEESLYARFSSIEVLGTLSRYEVDVIQKLQVDFVLTTLPLSIKGVPCLQVSPFFKDEDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCCCCEEECCCCCCCCHH
LIQTTIAQIAKSKQRQRQKHGATNEDFFRSIVEIAKANSKSFMLKPFMEELASLFKKHQL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
PVYEGVIQPLLAELMSEDHIELNVRAANWQEAIYAAAKPLERSGAITKNYAEAMIASVHE
CHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
YGPYIVLAPGVAIAHARPEDGVNELSVSFIQLAEPIPFGNPDNDPVFLVICLAASDSFSH
HCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCHHH
LKAFRSIVKLINDEQRLDAIKAATSKQSLTRIVLNEEGEKAYVDGP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCC
>Mature Secondary Structure
MKRKHAEIFQEIVRHKGYVPVKSLSETFQVSARTIRYALEEIDDYLRDHQQPPLKRNRKK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCC
GVYYDCDQEVLHKLLGSDTLHFPDAADREAFLVFAFFYAEEKVTVPSICEHLLVSKSTVD
CCEECCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KDIQRLRTELLADNLRIDSLPKEGFAVVGSEFAKRRWLFRFLKRACRNRGLDMLKQSEAA
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
TFFEDYCCKLVEATALEQTLAWIRTIEQQKNGRFTYETHLEIGLYALLALKRIKMGYLLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
EKVMVPEQLDKQAFALAQTFDFQKPVTELNTEIYVLSLFLSTAKEEQFLFKMEGNWGQIQ
HHCCCHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCEEE
VAVMDFVHSITKQTGLPFVNDQEYFSSIYAHIQTMARRLKNELPIENPIADVIVKQYPDL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHH
FAACRMAGNELERTLQLTIPIDEIAYLTMHTCVASERLKRQTLVYRTVIICGHGITNARL
HHHHHHHHHHHHCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IEESLYARFSSIEVLGTLSRYEVDVIQKLQVDFVLTTLPLSIKGVPCLQVSPFFKDEDTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCCCCEEECCCCCCCCHH
LIQTTIAQIAKSKQRQRQKHGATNEDFFRSIVEIAKANSKSFMLKPFMEELASLFKKHQL
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
PVYEGVIQPLLAELMSEDHIELNVRAANWQEAIYAAAKPLERSGAITKNYAEAMIASVHE
CHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHH
YGPYIVLAPGVAIAHARPEDGVNELSVSFIQLAEPIPFGNPDNDPVFLVICLAASDSFSH
HCCEEEEECCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCHHH
LKAFRSIVKLINDEQRLDAIKAATSKQSLTRIVLNEEGEKAYVDGP
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]