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The map label for this gene is clpP

Identifier: 56964790

GI number: 56964790

Start: 3148571

End: 3149158

Strand: Direct

Name: clpP

Synonym: ABC3026

Alternate gene names: 56964790

Gene position: 3148571-3149158 (Clockwise)

Preceding gene: 56964787

Following gene: 56964791

Centisome position: 73.16

GC content: 44.73

Gene sequence:

>588_bases
ATGAATTTAATACCTACCGTAATTGAACAAACAAACCGTGGCGAGCGTGCATATGACATTTACTCCCGTTTATTGAAAGA
CCGCATTATTATGCTAGGGAGCGGGGTGGACGACAATGTCGCCAACTCGATCGTTGCACAAATGTTGTTTTTGCAAGCAG
AAGACCCTGAAAAAGATATTTCCTTATACATTAACTCTCCTGGCGGCTCGATTACTGCTGGAATGGCGATCTATGACACG
ATGCAATTCATCAAACCAGATGTTTCAACGATTTGCATCGGCATGGCTGCTTCCATGGGCGCCTTTTTGCTCACTGCTGG
TGCGAAAGGCAAACGGATGGCATTGCCAAATAGTGAAGTGATGATCCACCAACCACTTGGCGGTATGCAAGGCCAAGCTG
CAGACATGGAAATCCATGCCCGCCGCATCATTCAAATGCGCGAAAAACTCAATCAAATTATGGCAGAACGTTCTGGTCAA
CCGTATGAACGAATTGCAAGAGACACAGACCGTGATAACTTTATGACAGCCGAACAAGCAAAAGAATACGGCTTAATCGA
CAAAGTGATTGAAACACCAACAAAATAA

Upstream 100 bases:

>100_bases
AAGAAGCAACTCATTTGACCTTTATTGACCTTTGCAGTATGATGATTACAGAGCAACAATTTCAAGGATTTTAGTCAATA
GGACATGAGGAGGAAGAGCG

Downstream 100 bases:

>100_bases
CAGACAAAGGCTTCCGCAAAACGCGGAAGCTTTTTTGTTGCCGCCAGTTGCAGCCTGCCCTCATTCAATTCCCTTTTTCA
TTAGGCCATGGTACGATTTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDISLYINSPGGSITAGMAIYDT
MQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEVMIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQ
PYERIARDTDRDNFMTAEQAKEYGLIDKVIETPTK

Sequences:

>Translated_195_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDISLYINSPGGSITAGMAIYDT
MQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEVMIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQ
PYERIARDTDRDNFMTAEQAKEYGLIDKVIETPTK
>Mature_195_residues
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDISLYINSPGGSITAGMAIYDT
MQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEVMIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQ
PYERIARDTDRDNFMTAEQAKEYGLIDKVIETPTK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP2 is involved in the complete degradation of the Site-2 clipped anti- sigma

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=51.2820512820513, Blast_Score=218, Evalue=2e-57,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=70, Blast_Score=288, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=53.2258064516129, Blast_Score=217, Evalue=4e-57,
Organism=Drosophila melanogaster, GI20129427, Length=193, Percent_Identity=55.9585492227979, Blast_Score=239, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_BACSK (Q5WDK0)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_176521.1
- ProteinModelPortal:   Q5WDK0
- SMR:   Q5WDK0
- STRING:   Q5WDK0
- MEROPS:   S14.001
- EnsemblBacteria:   EBBACT00000045912
- GeneID:   3203827
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC3026
- NMPDR:   fig|66692.3.peg.2915
- eggNOG:   COG0740
- GeneTree:   EBGT00050000002046
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   BCLA66692:ABC3026-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21602; Mature: 21602

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
7.2 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSITAGMAIYDTMQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEV
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCE
MIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQPYERIARDTDRDNFMTAEQA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHH
KEYGLIDKVIETPTK
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSGVDDNVANSIVAQMLFLQAEDPEKDI
CCCCCHHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
SLYINSPGGSITAGMAIYDTMQFIKPDVSTICIGMAASMGAFLLTAGAKGKRMALPNSEV
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCE
MIHQPLGGMQGQAADMEIHARRIIQMREKLNQIMAERSGQPYERIARDTDRDNFMTAEQA
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHH
KEYGLIDKVIETPTK
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA