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The map label for this gene is lexA [H]

Identifier: 56964628

GI number: 56964628

Start: 2991828

End: 2992457

Strand: Direct

Name: lexA [H]

Synonym: ABC2864

Alternate gene names: 56964628

Gene position: 2991828-2992457 (Clockwise)

Preceding gene: 56964621

Following gene: 56964629

Centisome position: 69.51

GC content: 38.57

Gene sequence:

>630_bases
ATGACAGACCCAAAAACGCTATTAGCTGAAAATCTAATGAAGGCAAGAATACGTAAAGGTTATAGCCAAACAGACTTAGC
TGAGATTTTAAATGTATCTTCGGCAACCATTAGCCAATATGAAAAGGGGAAAAGATCACCTGATGTTGAAAAGCTGCACA
CGATAGCTAAAGTTTTGGACACAACAATTCCGGAACTCATAATGGGACAATCAGACAATGAAGCATTAAAACTAAACATG
CAGTCACTTGTAAAAATTCCTATACTCGGAACTGTAAGAGCAGGTTATAATTTATTGGCCGATGAAAATGTTATTGGCTA
CGCTTATGCTCCTAAATCAGACATTGGGGACGGTGATTATTTCTATTTAAATATAGAAGGAGATTCGATGATTGACGCTG
GTTTAAATAGTGGTGATAGAATACTTGTCAGAAAACAAAACCACACAAGTGACGGGTCTATAGCAGTTGTATTAATAAAT
GGCGAAGAAGCGACTGTGAAGCGCGTATTTTTTGACAGTAACAAAGTGATTCTCAGCCCCGAAAATCCGCATATGCGCCC
CCAATTTTATGATGAAGATGAAATACGCATCCTCGGAAAAGTCGTGTCTGCATCAAGGACGTACGAATGA

Upstream 100 bases:

>100_bases
ATCACAAAACGTTAAAAGTCAAACGTTTATTTAGCATTCGTTAAAATAAATTTTATTCTATTTTATTAAACGTGAAAATA
TAAACGGAAGGTGAATAAGA

Downstream 100 bases:

>100_bases
GAACAGCGGTTTACATTAGAGTTAGTACAGAAGAGCAGGTAAATGAAGGTTACTCTATATCAGCTCAAAGAGAACGACTT
CAAGCGTATATAACTTCTCA

Product: SOS-response transcriptional repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTDPKTLLAENLMKARIRKGYSQTDLAEILNVSSATISQYEKGKRSPDVEKLHTIAKVLDTTIPELIMGQSDNEALKLNM
QSLVKIPILGTVRAGYNLLADENVIGYAYAPKSDIGDGDYFYLNIEGDSMIDAGLNSGDRILVRKQNHTSDGSIAVVLIN
GEEATVKRVFFDSNKVILSPENPHMRPQFYDEDEIRILGKVVSASRTYE

Sequences:

>Translated_209_residues
MTDPKTLLAENLMKARIRKGYSQTDLAEILNVSSATISQYEKGKRSPDVEKLHTIAKVLDTTIPELIMGQSDNEALKLNM
QSLVKIPILGTVRAGYNLLADENVIGYAYAPKSDIGDGDYFYLNIEGDSMIDAGLNSGDRILVRKQNHTSDGSIAVVLIN
GEEATVKRVFFDSNKVILSPENPHMRPQFYDEDEIRILGKVVSASRTYE
>Mature_208_residues
TDPKTLLAENLMKARIRKGYSQTDLAEILNVSSATISQYEKGKRSPDVEKLHTIAKVLDTTIPELIMGQSDNEALKLNMQ
SLVKIPILGTVRAGYNLLADENVIGYAYAPKSDIGDGDYFYLNIEGDSMIDAGLNSGDRILVRKQNHTSDGSIAVVLING
EEATVKRVFFDSNKVILSPENPHMRPQFYDEDEIRILGKVVSASRTYE

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=175, Percent_Identity=32.5714285714286, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019885
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23182; Mature: 23050

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPKTLLAENLMKARIRKGYSQTDLAEILNVSSATISQYEKGKRSPDVEKLHTIAKVLD
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
TTIPELIMGQSDNEALKLNMQSLVKIPILGTVRAGYNLLADENVIGYAYAPKSDIGDGDY
HHHHHHHCCCCCCCEEEEEHHHHEEECCEEECCCCCEEEECCCEEEEEECCCCCCCCCCE
FYLNIEGDSMIDAGLNSGDRILVRKQNHTSDGSIAVVLINGEEATVKRVFFDSNKVILSP
EEEEECCCCEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECC
ENPHMRPQFYDEDEIRILGKVVSASRTYE
CCCCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDPKTLLAENLMKARIRKGYSQTDLAEILNVSSATISQYEKGKRSPDVEKLHTIAKVLD
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
TTIPELIMGQSDNEALKLNMQSLVKIPILGTVRAGYNLLADENVIGYAYAPKSDIGDGDY
HHHHHHHCCCCCCCEEEEEHHHHEEECCEEECCCCCEEEECCCEEEEEECCCCCCCCCCE
FYLNIEGDSMIDAGLNSGDRILVRKQNHTSDGSIAVVLINGEEATVKRVFFDSNKVILSP
EEEEECCCCEEECCCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECC
ENPHMRPQFYDEDEIRILGKVVSASRTYE
CCCCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA