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The map label for this gene is trpS [H]

Identifier: 56964300

GI number: 56964300

Start: 2652758

End: 2653747

Strand: Direct

Name: trpS [H]

Synonym: ABC2535

Alternate gene names: 56964300

Gene position: 2652758-2653747 (Clockwise)

Preceding gene: 56964298

Following gene: 56964303

Centisome position: 61.64

GC content: 46.26

Gene sequence:

>990_bases
ATGCAAACCGTTTTTTCTGGAATTCAACCGAGCGGCACGTTGACGCTTGGCAACTATTTAGGGGCATTGAAACACTTTGC
CGACATGCAAAATGACTATGATTGCTTCTTTTGTATTGTGGACCAGCATGCGATAACGGTACCACAAGAGCGTTTGAAAC
TACGCGAAAACATCCGCAGCCTCGCCGCCCTTTACATCGCATCAGGAATCGACCCAAACAAGTCGACATTGTTTATCCAG
TCGGAAGTGCCAGCCCATGCCCAGCTAGGCTGGATGATGCAATGTGTTTCCTATATTGGCGAATTGGAACGCATGACCCA
ATTTAAAGACAAATCCAGCGGTAAAGAGGCCGTTTCGGCTGCGCTGTTAACGTATCCGCCGCTTATGGCCGCAGACATTC
TTCTTTATCAAACGGACATTGTGCCCGTTGGCGAAGACCAAAAGCAGCATTTGGAATTAACCCGCAATTTGGCGGAGCGC
TTTAACGCTAAGTACAATGATATTTTTACTGTTCCTGACGTGCGCATCCCGAAAGTCGGCGCAAGAATTATGTCTTTAAA
TGACCCTCATAAAAAAATGAGCAAATCAAATCCCAATGCGAAAAGCTATATTTCCATGCTTGACGAGCCAAAGACGATTG
CAAAGAAAATTAAAAGCGCCGTCACCGATTCAGAAGGTACCATTCGTTTTGATCGTGAAGAAAAGCCAGCGGTCTCTAAC
TTGCTTTCGATTTTTTCTCTTTGCTCTGGCAAATCGGTTACAGAGCTTGAACAACTGTATGAAGGCTCCGGCTACGGCCC
TTTTAAAGCCGACCTTGCCGACGCAGTCATTGAAGCGCTGCAACCAGTGCAAACACGTTACTATGAGTTGATTGAATCAG
CCGAACTTGATGCGATATTGGACAAAGGTGCAGACAAAGCGAACCGCAAAGCACAAAAAACGCTCGTAAAAGCAGAGCGT
GCGATGGGCTTAGGCAGAAAGAGAAGATAA

Upstream 100 bases:

>100_bases
CCTCTTTATGCATGGCCTTTACCTTGTTTAGATGGAAGAGTTGTGTTTGCTTGCATTTTGATTTACGATGGAGAAGAGTG
ACAAAACAGGAGTTGAACGT

Downstream 100 bases:

>100_bases
CCTGATAAAACATAAGCATTTTATGTCCTAACGTTAAAACGACGTAGCCGTGGGCTACGTCGTTTCCGTTAAAGTAATGA
TAATTTGTTTCTTAATAGCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQTVFSGIQPSGTLTLGNYLGALKHFADMQNDYDCFFCIVDQHAITVPQERLKLRENIRSLAALYIASGIDPNKSTLFIQ
SEVPAHAQLGWMMQCVSYIGELERMTQFKDKSSGKEAVSAALLTYPPLMAADILLYQTDIVPVGEDQKQHLELTRNLAER
FNAKYNDIFTVPDVRIPKVGARIMSLNDPHKKMSKSNPNAKSYISMLDEPKTIAKKIKSAVTDSEGTIRFDREEKPAVSN
LLSIFSLCSGKSVTELEQLYEGSGYGPFKADLADAVIEALQPVQTRYYELIESAELDAILDKGADKANRKAQKTLVKAER
AMGLGRKRR

Sequences:

>Translated_329_residues
MQTVFSGIQPSGTLTLGNYLGALKHFADMQNDYDCFFCIVDQHAITVPQERLKLRENIRSLAALYIASGIDPNKSTLFIQ
SEVPAHAQLGWMMQCVSYIGELERMTQFKDKSSGKEAVSAALLTYPPLMAADILLYQTDIVPVGEDQKQHLELTRNLAER
FNAKYNDIFTVPDVRIPKVGARIMSLNDPHKKMSKSNPNAKSYISMLDEPKTIAKKIKSAVTDSEGTIRFDREEKPAVSN
LLSIFSLCSGKSVTELEQLYEGSGYGPFKADLADAVIEALQPVQTRYYELIESAELDAILDKGADKANRKAQKTLVKAER
AMGLGRKRR
>Mature_329_residues
MQTVFSGIQPSGTLTLGNYLGALKHFADMQNDYDCFFCIVDQHAITVPQERLKLRENIRSLAALYIASGIDPNKSTLFIQ
SEVPAHAQLGWMMQCVSYIGELERMTQFKDKSSGKEAVSAALLTYPPLMAADILLYQTDIVPVGEDQKQHLELTRNLAER
FNAKYNDIFTVPDVRIPKVGARIMSLNDPHKKMSKSNPNAKSYISMLDEPKTIAKKIKSAVTDSEGTIRFDREEKPAVSN
LLSIFSLCSGKSVTELEQLYEGSGYGPFKADLADAVIEALQPVQTRYYELIESAELDAILDKGADKANRKAQKTLVKAER
AMGLGRKRR

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=324, Percent_Identity=39.8148148148148, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI41352700, Length=172, Percent_Identity=50, Blast_Score=179, Evalue=4e-45,
Organism=Escherichia coli, GI1789786, Length=325, Percent_Identity=55.3846153846154, Blast_Score=364, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI71982800, Length=328, Percent_Identity=37.8048780487805, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI71982793, Length=328, Percent_Identity=37.8048780487805, Blast_Score=223, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320474, Length=344, Percent_Identity=40.1162790697674, Blast_Score=233, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24666151, Length=325, Percent_Identity=41.2307692307692, Blast_Score=252, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 36646; Mature: 36646

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVFSGIQPSGTLTLGNYLGALKHFADMQNDYDCFFCIVDQHAITVPQERLKLRENIRS
CCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LAALYIASGIDPNKSTLFIQSEVPAHAQLGWMMQCVSYIGELERMTQFKDKSSGKEAVSA
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLTYPPLMAADILLYQTDIVPVGEDQKQHLELTRNLAERFNAKYNDIFTVPDVRIPKVG
HHHHCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHH
ARIMSLNDPHKKMSKSNPNAKSYISMLDEPKTIAKKIKSAVTDSEGTIRFDREEKPAVSN
HHHHCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHH
LLSIFSLCSGKSVTELEQLYEGSGYGPFKADLADAVIEALQPVQTRYYELIESAELDAIL
HHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKGADKANRKAQKTLVKAERAMGLGRKRR
HCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQTVFSGIQPSGTLTLGNYLGALKHFADMQNDYDCFFCIVDQHAITVPQERLKLRENIRS
CCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHH
LAALYIASGIDPNKSTLFIQSEVPAHAQLGWMMQCVSYIGELERMTQFKDKSSGKEAVSA
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
ALLTYPPLMAADILLYQTDIVPVGEDQKQHLELTRNLAERFNAKYNDIFTVPDVRIPKVG
HHHHCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCHH
ARIMSLNDPHKKMSKSNPNAKSYISMLDEPKTIAKKIKSAVTDSEGTIRFDREEKPAVSN
HHHHCCCCHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHH
LLSIFSLCSGKSVTELEQLYEGSGYGPFKADLADAVIEALQPVQTRYYELIESAELDAIL
HHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DKGADKANRKAQKTLVKAERAMGLGRKRR
HCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]