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The map label for this gene is lexA

Identifier: 56963932

GI number: 56963932

Start: 2286160

End: 2286786

Strand: Direct

Name: lexA

Synonym: ABC2167

Alternate gene names: 56963932

Gene position: 2286160-2286786 (Clockwise)

Preceding gene: 56963924

Following gene: 56963935

Centisome position: 53.12

GC content: 44.82

Gene sequence:

>627_bases
ATGTCGAAATTATCGAAGCGCCAGGAAGAAATTTTGGCGTACATAAAAGATGAAGTAAAGAAAAAAGGGTACCCGCCGTC
CGTCCGGGAAATTGGTGAAGCAGTTGGACTTGCTTCAAGTTCCACCGTACACGGCCACTTGGCCAGATTAGAAAAAAAAG
GCTACATTCGCCGCGATCCTACTAAACCGCGGGCGATTGAAGTCCTTTCTCTCGGATTTGATAATGATACATTTGTCAAA
AAAGAGACAGCAAGCTTTATTCCGGTAATCGGAAAAGTTACCGCAGGTGTGCCAATTACTGCTGTTGAAAACGTCGAAGA
TTACTTGCCACTCCCCGACCACCTTGCCGCTTACGACAATACGTATGCGCTTGTCATTCAAGGGGAAAGCATGATTGAAG
CAGGTATTTACGATGGAGACCAAGTGATCGTACGGCAACAGCAAACAGCCGATAATGGCGATATTATTGTAGCCATGACA
GAAGATAATGAAGCAACAGTAAAACGGTTTTTCCGGGAAAAGGACTACATTCGTCTCCAACCAGAGAATTCTTCAATGGA
ACCAATTATCCTTGAAAACTGCACGATTCTCGGAAAAGTCATCGGAGTGTTCCGCACGATCCACTAA

Upstream 100 bases:

>100_bases
ACTGTTCGTGTCAACTACTTTTTTTAGAACTTATGTTTGCGTTCATACGTTCGATATGGTAAAGTTTGTTTAGAACAGTC
ATATGAAAGCAGGTGGGAAA

Downstream 100 bases:

>100_bases
CGGACCAATAGGCTTTTTCAAGCTGTTGACCAAGCCCCTTAAATCTGAAATACGCTTGTCAGATGGAAGCAAAACAAAAG
AGGTTCGTGCTTGACACGAC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSKLSKRQEEILAYIKDEVKKKGYPPSVREIGEAVGLASSSTVHGHLARLEKKGYIRRDPTKPRAIEVLSLGFDNDTFVK
KETASFIPVIGKVTAGVPITAVENVEDYLPLPDHLAAYDNTYALVIQGESMIEAGIYDGDQVIVRQQQTADNGDIIVAMT
EDNEATVKRFFREKDYIRLQPENSSMEPIILENCTILGKVIGVFRTIH

Sequences:

>Translated_208_residues
MSKLSKRQEEILAYIKDEVKKKGYPPSVREIGEAVGLASSSTVHGHLARLEKKGYIRRDPTKPRAIEVLSLGFDNDTFVK
KETASFIPVIGKVTAGVPITAVENVEDYLPLPDHLAAYDNTYALVIQGESMIEAGIYDGDQVIVRQQQTADNGDIIVAMT
EDNEATVKRFFREKDYIRLQPENSSMEPIILENCTILGKVIGVFRTIH
>Mature_207_residues
SKLSKRQEEILAYIKDEVKKKGYPPSVREIGEAVGLASSSTVHGHLARLEKKGYIRRDPTKPRAIEVLSLGFDNDTFVKK
ETASFIPVIGKVTAGVPITAVENVEDYLPLPDHLAAYDNTYALVIQGESMIEAGIYDGDQVIVRQQQTADNGDIIVAMTE
DNEATVKRFFREKDYIRLQPENSSMEPIILENCTILGKVIGVFRTIH

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=210, Percent_Identity=31.9047619047619, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_BACSK (Q5WG03)

Other databases:

- EMBL:   AP006627
- RefSeq:   YP_175663.1
- ProteinModelPortal:   Q5WG03
- SMR:   Q5WG03
- STRING:   Q5WG03
- EnsemblBacteria:   EBBACT00000046471
- GeneID:   3204066
- GenomeReviews:   AP006627_GR
- KEGG:   bcl:ABC2167
- NMPDR:   fig|66692.3.peg.2471
- eggNOG:   COG1974
- GeneTree:   EBGT00050000002279
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- BioCyc:   BCLA66692:ABC2167-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 23179; Mature: 23048

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: ACT_SITE 130-130 ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLSKRQEEILAYIKDEVKKKGYPPSVREIGEAVGLASSSTVHGHLARLEKKGYIRRDP
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCC
TKPRAIEVLSLGFDNDTFVKKETASFIPVIGKVTAGVPITAVENVEDYLPLPDHLAAYDN
CCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCHHHHHCCC
TYALVIQGESMIEAGIYDGDQVIVRQQQTADNGDIIVAMTEDNEATVKRFFREKDYIRLQ
EEEEEEECCHHEECCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCEEEC
PENSSMEPIILENCTILGKVIGVFRTIH
CCCCCCCCEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKLSKRQEEILAYIKDEVKKKGYPPSVREIGEAVGLASSSTVHGHLARLEKKGYIRRDP
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCCEECCC
TKPRAIEVLSLGFDNDTFVKKETASFIPVIGKVTAGVPITAVENVEDYLPLPDHLAAYDN
CCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCHHHHHCCC
TYALVIQGESMIEAGIYDGDQVIVRQQQTADNGDIIVAMTEDNEATVKRFFREKDYIRLQ
EEEEEEECCHHEECCCCCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCCCEEEC
PENSSMEPIILENCTILGKVIGVFRTIH
CCCCCCCCEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA